Co-doped nano-calcium phosphate antibacterial material containing cations and anions and preparation method of co-doped nano-calcium phosphate antibacterial material
A technology of nano-calcium phosphate, anion and cation, applied in the fields of pharmaceutical formulation, medical science, prosthesis, etc., can solve the problem of difficult coordination of antibacterial ability and osteogenic activity, and achieve good biodescriptiveness, good dispersibility, and adjustable release rate Effect
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Embodiment 1
[0029] a: Prepare 8mL of 0.1mol / L potassium dihydrogen phosphate solution, adjust the pH value to 7.0, and dilute to 10mL;
[0030] b: Mix 3.4mL 0.01mol / L copper nitrate solution with 8.6mL 0.1mol / L calcium nitrate solution and stir evenly;
[0031] c: Add the solution of step b to the solution of step a dropwise, stir and oscillate at 30°C, 200 rpm, and maintain the pH value at 11.0. After the titration, age at room temperature for one day, then wash and dry to obtain copper-containing phosphoric acid Calcium granules.
Embodiment 2
[0033] a: Prepare 6.0mL 2mmol / L diammonium hydrogen phosphate solution and adjust the pH value to 9.0;
[0034] b: Stir 1mL 2mmol / L magnesium chloride salt solution and 9mL 2mmol / L calcium chloride solution evenly;
[0035] c: Add the solution of step b to the solution of step a dropwise, stir and oscillate at 60°C, 600 rpm, and maintain the pH value at 9.0. After the titration is completed, age at room temperature for one day, then wash and dry to obtain magnesium-containing phosphoric acid Calcium particles
Embodiment 3
[0037] a: Prepare 5.2mL 1mmol / L disodium hydrogen phosphate solution, adjust the pH value to 10.0, and dilute to 10ml;
[0038] b: Mix 2mL 2mmol / L silver nitrate solution with 10mL 1mmol / L calcium nitrate, and stir evenly;
[0039] c: Add the solution of step b to the solution of step a dropwise, stir and oscillate at 45°C, 400 rpm, and maintain the pH value at 10.0. After the titration, age at room temperature for one day, then wash and dry to obtain silver-containing phosphoric acid Calcium granules.
[0040] Example 1
[0041] a: Add 1.2mL 0.1mol / L ammonium fluoride solution to 7.6mL 0.1mol / L potassium dihydrogen phosphate solution, adjust the pH value to 7.0;
[0042]b: Mix 3.4mL 0.01mol / L copper nitrate solution with 8.6mL 0.1mol / L calcium nitrate solution and stir evenly;
[0043] c: Add the solution of step b and 5mL of γ-polyglutamic acid modifier solution to the solution of step a dropwise at the same time, stir and oscillate at 30°C, 200 rpm, and maintain the pH v...
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