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Preparation process of compound honeysuckle film-coated tablet

A compound honeysuckle and film coating technology, which is applied in the directions of non-active ingredients medical preparations, medical preparations containing active ingredients, pharmaceutical formulas, etc. problems, to achieve the effect of improved efficiency, short drying time and low water absorption

Inactive Publication Date: 2020-11-20
右江民族医学院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Currently commonly used film-coated tablets have the disadvantages of too high viscosity, easy to bond, low production efficiency, and high water absorption.

Method used

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  • Preparation process of compound honeysuckle film-coated tablet

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] A kind of preparation technology of compound honeysuckle film-coated tablet, comprises the steps:

[0028] (1) Weigh each raw material according to the following weight ratio: 750 parts of honeysuckle, 750 parts of forsythia and 250 parts of scutellaria baicalensis; put the honeysuckle in the extraction tank, add water 10 times its mass, and then add 1.5% chlorine Sodium chloride and 1.2% compound enzyme, the compound enzyme is composed of cellulase and pectinase with a mass ratio of 2:1, stirred evenly, heated to 70°C, extracted for 5h, filtered, and the honeysuckle filtrate was collected;

[0029] (2) Add forsythia and scutellaria baicalensis into the extraction tank, add water 8 times the weight of the medicinal materials, decoct 3 times, decoct for 2 hours each time, filter, combine the filtrate and then combine it with the honeysuckle filtrate; at a vacuum degree of -0.08Mpa, Concentrate at a temperature of 70°C to a relative density of 1.15 to obtain a thick paste...

Embodiment 2

[0034] A kind of preparation technology of compound honeysuckle film-coated tablet, comprises the steps:

[0035] (1) Weigh each raw material according to the following weight ratio: 750 parts of honeysuckle, 750 parts of forsythia and 250 parts of scutellaria baicalensis; put the honeysuckle in the extraction tank, add water 12 times its mass, and then add 0.8% chlorine Sodium chloride and 1.5% compound enzyme, the compound enzyme is composed of cellulase and pectinase with a mass ratio of 1:1, stirred evenly, heated to 70°C, extracted for 5h, filtered, and the honeysuckle filtrate was collected;

[0036] (2) Add forsythia and scutellaria baicalensis into the extraction tank, then add water 10 times the weight of the medicinal materials, decoct twice for 2.5 hours each time, filter, combine the filtrate and then combine with the honeysuckle filtrate; the vacuum degree is -0.06Mpa 1. Concentrate to a relative density of 1.10 at a temperature of 65°C to obtain a thick paste, an...

Embodiment 3

[0041] A kind of preparation technology of compound honeysuckle film-coated tablet, comprises the steps:

[0042] (1) Weigh each raw material according to the following weight ratio: 750 parts of honeysuckle, 750 parts of forsythia and 250 parts of scutellaria baicalensis; put the honeysuckle in the extraction tank, add water 9 times its mass, and then add 1.6% chlorine Sodium chloride and 1.2% compound enzyme, the compound enzyme is composed of cellulase and pectinase with a mass ratio of 1:1, stirred evenly, heated to 60°C, extracted for 6h, filtered, and the honeysuckle filtrate was collected;

[0043] (2) Add forsythia and scutellaria baicalensis into the extraction tank, then add water 9 times the weight of the medicinal materials, decoct 3 times for 1.5 hours each time, filter, combine the filtrate and then combine with the honeysuckle filtrate; the vacuum degree is -0.10Mpa 1. Concentrate to a relative density of 1.15 at a temperature of 60°C to obtain a thick paste, an...

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Abstract

The invention discloses a preparation process of a compound honeysuckle film-coated tablet. The method comprises the following steps: heating and extracting honeysuckle, and collecting honeysuckle filtrate, adding forsythia suspensa and scutellaria baicalensis into an extraction tank, adding water, decocting, filtering, combining filtrates, and mixing with the honeysuckle filtrate, concentrating to obtain an extract, and drying to obtain dry paste powder, adding starch, soybean gum, konjac glucomannan and phlorizin into the dry extract powder, uniformly mixing, uniformly mixing with magnesiumstearate, and tabletting to obtain the compound lonicerae flos tablets. Adding sodium carboxymethyl cellulose, polyethylene glycol, polyvinyl alcohol, beta-cyclodextrin, a plasticizer and a coloring agent into a high-speed dispersion machine to prepare a coating solution, and placing the plain tablets and the coating solution in a coating machine for spraying and coating, and drying to obtain thecompound honeysuckle film coated tablets. The compound honeysuckle flower film-coated tablet prepared by the invention has the advantages of moisture resistance, light shielding, taste masking, low water absorption and the like, is not easy to generate cracks, spots and mildew spots, improves the stability of the medicine, and prolongs the storage period, the processing fluidity is good and the production efficiency is improved.

Description

technical field [0001] The invention relates to the technical field of Chinese patent medicine preparations, in particular to a preparation process of compound honeysuckle film-coated tablets. Background technique [0002] Compound honeysuckle granules are traditional Chinese medicine preparations made from honeysuckle, forsythia, and baicalin through extraction and processing, and have been sold in the market. It has the effects of clearing heat and detoxification, cooling blood and reducing swelling, and is widely used for wind-heat and cold, pharyngitis, tonsillitis, eye pain, toothache, carbuncle, sores and boils. Currently, the commercially available compound honeysuckle preparations are mainly granule preparations. According to market sales, patient feedback and inspection of finished product samples, the compound honeysuckle granules are prone to moisture, mildew and deterioration during storage, which affects the efficacy of the drug and directly affects With the ef...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/634A61K9/36A61K9/32A61K47/26A61K47/14A61P1/02A61P11/04A61P17/02
CPCA61K9/2018A61K9/205A61K9/2059A61K9/282A61K9/2826A61K9/284A61K9/2853A61K9/286A61K9/2866A61K9/2893A61K36/355A61K36/539A61K36/634A61K2236/19A61K2236/331A61P1/02A61P11/04A61P17/02A61K2300/00
Inventor 黄锁义李童陈石梅李惠莉
Owner 右江民族医学院
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