Application of Tripterygium wilfordii Polyglycoside Tablets in the Preparation of Medicines for Alleviating and/or Treating Symptoms Related to Hemophagocytic Syndrome

A technology of rattan polyglycoside tablets and blood cells, which is applied in the field of medicine and can solve the problems of no very effective treatment method and poor curative effect for hemophagocytic syndrome

Active Publication Date: 2022-03-29
JIANGSU PROVINCIAL HOSPITAL OF TCM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, there is no very effective treatment for hemophagocytic syndrome. The general treatment refers to the HLH-2004 regimen, that is, gamma globulin + dexamethasone + etoposide + cyclosporine A, but the curative effect is not good

Method used

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  • Application of Tripterygium wilfordii Polyglycoside Tablets in the Preparation of Medicines for Alleviating and/or Treating Symptoms Related to Hemophagocytic Syndrome
  • Application of Tripterygium wilfordii Polyglycoside Tablets in the Preparation of Medicines for Alleviating and/or Treating Symptoms Related to Hemophagocytic Syndrome
  • Application of Tripterygium wilfordii Polyglycoside Tablets in the Preparation of Medicines for Alleviating and/or Treating Symptoms Related to Hemophagocytic Syndrome

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030]Example 1: Tripterygium wilfordii polyglycoside tablets can quickly curb the cytokine storm and relieve the patient's hemophagocytosis-related symptoms.

[0031] The patient, a 44-year-old woman, was admitted to the hospital in December 2017 because of "fever for 3 months and abdominal distension for 3 weeks". Medical history: Fever began in September 2017, and the body temperature fluctuated at 37.4-38.1°C, accompanied by dull pain in the lower abdomen. In October 2017, a cough occurred, with less sputum, white color, high fever, heat peak 39.0 ℃, accompanied by abdominal distension, blood test: white blood cell count 2.28×10 9 / L, hemoglobin 122g / L, platelet 133×10 9 / L. Chest CT plain scan showed: infection in the middle and lower lobe of the right lung and tongue segment of the left lung, enlarged spleen, and peritoneal effusion. Cervical lymph node color Doppler ultrasound: right cervical (region IV) lymph node enlargement; bilateral axillary lymph node enlargeme...

Embodiment 2

[0033] Example 2: Tripterygium wilfordii polyglycoside tablets can significantly alleviate the symptoms related to hemophagocytosis in patients.

[0034] The patient is a 50-year-old male who was admitted to the hospital in December 2019. After being admitted to the hospital, he had repeated high fever, with a temperature peak of 40.1°C ( Figure 6 A); neutrophils minimum 0.72×10 9 / L, minimum hemoglobin 71g / L, platelet minimum 26×10 9 / L; plasma fibrinogen 1.15g / L ( Figure 6 B); serum ferritin 9453ng / mL ( Figure 6 C), LDH: 1892U / L; EBV-DNA: 6×10 4 of 12 serum cytokines detected in the laboratory, IL-1β=98.83pg / mL, IL-10=25.98pg / mL, TNF-α=23.34pg / mL; whole abdominal CT scan showed splenomegaly. Diagnosis of EBV-positive NK-T cell lymphoma, nasal type, extranodal NK-T, with hemophagocytic syndrome. At the beginning of admission, the HLH-2004 regimen was adopted, namely, dexamethasone 10mg qd, etoposide 150mg biw, and intravenous gamma globulin 20g qd. The symptoms of he...

Embodiment 3

[0035] Example 3: Tripterygium wilfordii polyglycoside tablets can alleviate the patient's hemophagocytosis-related symptoms.

[0036] The patient was a 27-year-old male who was admitted to the hospital in February 2020. On admission, anemia, hemoglobin 76g / L, platelet 50×10 9 / L; plasma fibrinogen 0.93g / L; ferritin>1500.0ng / mL; mild damage to liver function, AST=147U / L, ALT=178U / L, total bilirubin (TBIL) 42.21μmol / L, LDH=2036U / L; EBV-DNA has 676 copies; chest CT plain scan shows splenomegaly. A diagnosis of EBV-positive B-cell lymphoma with hemophagocytic syndrome was made. On February 27, 2020, he started to treat with tripterygium glycosides tablets 10 mg tid, accompanied by dexamethasone, febuxostat, and Xiaoyu pills. After one week of treatment with tripterygium glycosides, the plasma fibrinogen level rose to 1.59g / L, liver function gradually recovered, ALT returned to normal level (27U / L), AST dropped to 52U / L, and total bilirubin TBIL dropped to 1.59g / L. To 35.2μmol...

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Abstract

The invention discloses the new medical application of the tripterygium glycosides tablet, in particular, the application of the tripterygium glycosides tablet in the preparation of medicines for relieving and / or treating symptoms related to hemophagocytic syndrome. The research of the present invention proves that Tripterygium wilfordii Polyglycoside Tablets can significantly alleviate the patients’ symptoms related to hemophagocytosis, including significant relief of repeated high fever, obvious relief of abdominal distension, relief of splenomegaly, reduction of ascites, and sharp decline of soluble CD25 content in blood, etc. The recovery of coagulation function also has a significant effect. Oral administration of Tripterygium wilfordii Polyglycoside Tablets can quickly curb the cytokine storm, quickly relieve various hemophagocytic related symptoms, and have less toxic and side effects. It can provide conditions for subsequent treatment, including chemotherapy and hematopoietic stem cell transplantation, and also has a good cost-benefit ratio. Can greatly reduce the cost of clinical treatment of patients.

Description

technical field [0001] The invention belongs to the field of medicine, and specifically relates to the new application of tripterygium glycosides tablets, more specifically, the application of tripterygium glycosides tablets in the preparation of medicines for alleviating and / or treating symptoms related to hemophagocytic syndrome. Background technique [0002] Hemophagocytic Syndrome, also known as Hemophagocytic Lymphohistiocytosis (HLH), is one of the most serious clinical diseases, generally manifested as persistent fever, hepatosplenomegaly, hematopenia, low Plasma fibrinosis or hypertriglyceridemia, hyperferritinemia, and hemophagocytosis in the bone marrow, liver, spleen, or lymph nodes. HLH is divided into two types: primary and secondary. Primary HLH includes familial HLH, Griscelli syndrome type Ⅱ, Chediak-Higashi syndrome and other genetic diseases. The onset of primary HLH usually occurs in childhood and is mainly caused by various infections. Secondary or acqu...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/37A61K9/20A61P7/00
CPCA61K36/37A61K9/20A61P7/00
Inventor 朱学军陈碧清代兴斌姜鹏君徐祖琼田芳孔祥图
Owner JIANGSU PROVINCIAL HOSPITAL OF TCM
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