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Graphene nanocomposite for treating burn wound multi-drug-resistant bacterial infection

A technology of multi-drug-resistant bacteria and nanocomposite materials, which can be used in the medical field to solve the problem of increasing the incidence of multi-drug-resistant bacterial infections

Inactive Publication Date: 2020-10-27
中国人民解放军32298部队
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0002] With the development of modern medical technology, the success rate of anti-shock resuscitation in the early stage of burn injury has been significantly improved. Incidence of infection has risen dramatically, posing a serious challenge to the health of burn patients

Method used

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Embodiment

[0037] A graphene nanocomposite material for the treatment of multidrug-resistant bacterial infections on burn wounds, comprising the following steps:

[0038] A. Design and preparation: Based on covalent and non-covalent reactions, carboxylated graphene is used as the substrate, the surface is coated with polydopamine coating, and the pH-sensitive ethylene glycol chitosan molecule / quaternary ammonium salt shell is cross-linked Glycan molecules are loaded with modified free radical initiator 2,2'-azobis[2-(2-imidazolin-2-yl)propane] dihydrochloride through non-covalent bonding to prepare nano-antibacterial materials;

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Abstract

The invention relates to the technical field of medical treatment, in particular to a graphene nanocomposite for treating burn wound multi-drug-resistant bacterial infection, which comprises the following steps: A, designing and preparing; B, characterization performance research: (1) hydrated particle size detection, (2) photo-thermal performance detection, (3) material stability analysis, (4) material surface size and morphology size analysis, (5) Fourier transform infrared spectrum, ultraviolet-visible light absorption spectrum and Raman spectrum analysis, and (6) material component analysis. Carboxylated graphene is used as a carrier, polydopamine is loaded on the surface, ethylene glycol chitosan is cross-linked into the system to prepare a modified graphene nano material, and finally, the modified graphene nano material is loaded on GCS-PDA-coated CG through non-covalent bond binding, the efficient photo-thermal induced targeted graphene nano antibacterial material (AIBI-GCS-PDA(@) CG) is formed, alkyl radicals can be released to kill multi-drug-resistant bacteria, and a new treatment strategy is expected to be provided for infection of the multi-drug-resistant bacteria on burn wounds.

Description

technical field [0001] The invention relates to the field of medical technology, in particular to a graphene nanocomposite material for the treatment of multidrug-resistant bacterial infections on burn wounds. Background technique [0002] With the development of modern medical technology, the success rate of anti-shock resuscitation in the early stage of burn injury has been significantly improved. The incidence of infection has risen dramatically, posing a serious challenge to the health of burn patients. Wound multidrug-resistant bacterial infection will not only aggravate wound deterioration, delay healing, and even lead to sepsis and eventually death, and has become one of the main causes of death in burn patients [1-3] . Due to the irrational use and slow development of antibiotics, the world is facing an incurable bacterial infection, which can be very serious and catastrophic. [4-6] . Therefore, the control of multidrug-resistant bacterial infection in wounds is ...

Claims

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Application Information

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IPC IPC(8): A61K41/00A61K47/04A61K47/34A61K47/36A61P17/02A61P31/04B82Y5/00
CPCA61K41/0057A61K41/0052A61K47/02A61K47/34A61K47/36A61P17/02A61P31/04B82Y5/00
Inventor 于洵洲肖树文赵志钢陈东升江柯萱李俊男杨学林
Owner 中国人民解放军32298部队
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