Preparation method of drug-loaded sodium alginate/gelatin composite hydrogel band-aid

Abstract

The invention discloses a preparation method of a drug-loaded sodium alginate / gelatin composite hydrogel band-aid. The method comprises the following steps: (1) mixing sodium alginate and a gelatin solution, and preparing sodium alginate / gelatin composite hydrogel by utilizing the characteristics of cross-linking between calcium ions and sodium alginate and cross-linking between glutamine transferase and gelatin; and (2) preparing the drug-loaded sodium alginate / gelatin composite hydrogel band-aid: loading a drug into the composite hydrogel, so that the finally prepared band-aid has the effects of resisting bacteria, diminishing inflammation and promoting wound healing. The drug-loaded sodium alginate / gelatin composite hydrogel band-aid is successfully prepared, the raw materials adopted in the preparation process are all non-toxic compounds, the preparation process is simple, and the cost is low. Experimental tests show that the composite hydrogel is of a porous structure and is beneficial to gas exchange; the swelling property is beneficial to absorption of exudate of the wound; and berberine serving as a drug model is successfully loaded into the composite hydrogel and can be slowly released, so that the composite hydrogel has an antibacterial effect.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and relates to a preparation method of a drug-loaded sodium alginate / gelatin composite hydrogel band-aid. Background technique [0002] In daily life, we always have some small accidents inadvertently, which cause frictional damage to the skin to varying degrees and bleeding from the wound. For minor skin surface wounds, we often use sterile gauze, antibiotics and other drugs to treat or use band-aids, but these methods may cause the dressing to stick to the wound, which is likely to cause secondary damage to the wound site, or when changing the dressing Not easy to peel off. [0003] Hydrogel is a colloid with a three-dimensional network structure rich in water. It is used in the field of wound dressings because of its softness, ability to maintain a certain shape, and good biocompatibility. The hydrogel has a certain swelling property, and it can maintain its own shape while absorbing wate...

AI Technical Summary

Problems solved by technology

For minor skin surface wounds, we often use sterile gauze, antibiotics and other drugs to treat or use band-aids, but these methods may cause the dressing to stick to the wound, which is likely to cause secondary damage to the wound site, or when changing the dressing not easy to peel off

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