Preparation method of a mesoporous silica complex with drug controlled release and imaging functions
A technology of mesoporous silica and drug controlled release, applied in the fields of nanomaterials and molecular medicine, can solve the problems of difficult real-time monitoring of curative effect, complicated implementation, etc., and achieve the effects of high sensitivity, reduced multidrug resistance, and strong characteristics.
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Embodiment 1
[0026] This embodiment 1 provides a method for preparing a mesoporous silica complex with both controlled drug release and imaging functions, the method comprising the following steps:
[0027] (1) Au / Fe 3 o 4 Nucleus preparation
[0028] Fe 3 o 4 Preparation of nanoparticles. 1g FeCl 3 ·6H 2 O and 0.37 g FeCl 2 4H 2 O mixed with 20mL deionized water for nitrogen deoxygenation; take 130mL deionized water in a 250mL round bottom flask for nitrogen deoxygenation, add 12.5mL of concentrated ammonia water with a concentration of 25-28%, and quickly pour it into it under vigorous stirring Pour the above-mentioned iron salt mixed solution, and react for 1 h (80°C) under nitrogen; after the reaction is completed, separate Fe from the reaction solution with a permanent magnet. 3 o 4 Magnetic nanoparticles, washed three times with methanol, were dispersed in 50 mL of toluene. Then, (3-aminopropyl)trimethoxysilane (APTES) (25 μL) was added to 12.5 mL of the above Fe 3 o 4 I...
Embodiment 2
[0037] This Example 2 provides a method for preparing a mesoporous silica complex with both drug controlled release and imaging functions, the method comprising the following steps:
[0038] (1) Au / Fe 3 o 4 Nucleus preparation
[0039] Fe 3 o 4 Preparation of nanoparticles. 1g FeCl 3 ·6H 2 O and 0.37 g FeCl 2 4H 2 O mixed with 30mL deionized water for nitrogen deoxygenation; take 160mL deionized water in a 250mL round bottom flask for nitrogen deoxygenation, add 15mL of concentrated ammonia water with a concentration of 25-28%, pour it into it quickly under vigorous stirring Add the above-mentioned iron salt mixed solution, and react for 2h (80°C) under nitrogen; after the reaction is completed, use a permanent magnet to separate Fe from the reaction solution. 3 o 4 Magnetic nanoparticles, washed three times with methanol, were dispersed in 60 mL of toluene. Then, (3-aminopropyl)trimethoxysilane (APTES) (20 μL) was added to 12.5 mL of the above Fe 3 o 4 In the sol...
Embodiment 3
[0047] This embodiment 3 provides a method for preparing a mesoporous silica complex with both drug controlled release and imaging functions, the method comprising the following steps:
[0048] (1) Au / Fe 3 o 4 Nucleus preparation
[0049] Fe 3 o 4 Preparation of nanoparticles. 1g FeCl 3 ·6H 2 O and 0.37 g FeCl 2 4H 2O mixed with 20mL deionized water for nitrogen deoxygenation; take 130mL deionized water in a 250mL round bottom flask for nitrogen deoxygenation, add 12.5mL of concentrated ammonia water with a concentration of 25-28%, and quickly pour it into it under vigorous stirring Pour the above-mentioned iron salt mixed solution, and react for 1 h (80°C) under nitrogen; after the reaction is completed, separate Fe from the reaction solution with a permanent magnet. 3 o 4 Magnetic nanoparticles, washed three times with methanol, were dispersed in 50 mL of toluene. Then, (3-aminopropyl)trimethoxysilane (APTES) (25 μL) was added to 12.5 mL of the above Fe 3 o 4 In...
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