Template usable for preparing low-stimulation and high-compliance tissue engineering blood vessel and tissue engineering blood vessel

Abstract

The invention belongs to the field of tissue engineering, and particularly relates to a template for preparing a low-stimulation and high-compliance tissue engineering blood vessel. The template comprises a skeleton main body (1), an inner core (2) and an anti-exposure layer (3), wherein the anti-exposure layer is arranged on the outer surface of the inner core; the skeleton main body is arrangedon the outer surface of the anti-exposure layer; the anti-exposure layer (3) comprises a degradable material and divalent cobalt ions; and the skeleton main body comprises a reticular fiber skeleton layer. The template has the beneficial effects that the anti-exposure layer is degraded to form a gap, and finally the surface of an inner cavity of a reticular fiber skeleton is coated with an acellular matrix, so that fiber exposure is reduced, and stimulation to blood coagulation reaction is reduced; the reticular fiber skeleton can enable the prepared tissue engineering blood vessel to have good mechanical properties; the bivalent cobalt ions in the anti-exposure layer can improve the compliance of the prepared tissue engineering blood vessel, reduce the occurrence rate of intimal hyperplasia and improve the tissue reproducibility after in-vivo implantation.

Description

technical field [0001] The invention belongs to the field of tissue engineering, and in particular relates to a template and a tissue engineering blood vessel which can be used for preparing low stimulation and high compliance tissue engineering blood vessels. Background technique [0002] Vascular disease is the disease with the highest fatality rate in the world. The occurrence of this disease is often due to the narrowing or blockage of blood vessels, which leads to reduced blood flow and lack of nutrients, which damages tissues or organs. It usually manifests as coronary heart disease, cerebrovascular disease, peripheral artery disease, etc. disease. According to the prediction of the World Health Organization, by 2030, the number of people dying of cardiovascular-related diseases in the world will increase to 23.3 million each year. Vascular transplantation is still a routine method for the treatment of such diseases. At present, the collection and use of patients' aut...

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Problems solved by technology

[0006] Second, the compliance of the blood vessel prepared by the above method is not good, and it will stimulate the excessive proliferation of smooth muscle cells after implantation in vivo, resulting in intimal hyperplasia;

[0007] Third, the outer surface of the tissue-engineered blood vessel prepared by subcutaneous implantation using the above-mentioned template is relatively smooth, and it is easy to slip after implantation, which reduces the integration rate of the blood vessel and the surrounding tissue of the implantation site;

[0008] Fourth, the regeneration of tissue engineering tubes prepared by the above method needs to be improved

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