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A kind of indocyanine green-phospholipid complex and its preparation method and application

A phospholipid complex, complex technology, applied in chemical instruments and methods, drug combinations, pharmaceutical formulations, etc., can solve problems such as inaccurate iron concentration assessment, and achieve excellent iron chelation performance, good biocompatibility and fluorescence. properties, the effect of accurate quantitative detection and dynamic monitoring

Active Publication Date: 2021-10-26
XIAMEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But when iron overload is measured using MRI, the amount of fat in the damaged liver and abnormal signals caused by massive iron overload can provide an inaccurate assessment of iron concentration, therefore, improving current MRI detection methods or introducing other imaging methods for accurate, noninvasive Clinical necessity to accurately detect excess iron in the body

Method used

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  • A kind of indocyanine green-phospholipid complex and its preparation method and application
  • A kind of indocyanine green-phospholipid complex and its preparation method and application
  • A kind of indocyanine green-phospholipid complex and its preparation method and application

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Embodiment 1

[0030] (a) Indocyanine green solution: First, weigh 1 mg of indocyanine green small molecule, add 1 mL of deionized aqueous solution, and use an ultrasonic cleaner to sonicate for 2 minutes to completely dissolve it;

[0031] (b) Indocyanine green-phospholipid complex: Weigh 1mg of indocyanine green small molecule and soybean lecithin respectively, add 1mL of deionized aqueous solution and use ultrasonic cleaner for 2min to dissolve completely; then mix 1:1 Uniform spare;

Embodiment 2

[0033] With reference to the accompanying drawings, in some embodiments, the following imaging target is an iron-containing aqueous solution.

[0034] (1) Add 100 μL of the ICG (500 μM)-phospholipid (1 mM) composite solution to 100 μL of ferric aqueous solution with different concentrations (0-500 μM), mix well, and scan the region to be scanned of the imaging target and Calculate the signal value. Such as figure 1 As shown, it can be seen that the photoacoustic value at 890nm of the ICG-phospholipid composite solution prepared in the present invention increases with the increase of iron ion concentration, which supplements and enhances the problem of insufficient MRI imaging sensitivity.

[0035] (2) Add 100 μL of ICG (500 μM), phospholipid (1 mM), and ICG (500 μM)-phospholipid (1 mM) composite solution to 100 μL of ferric aqueous solution with different concentrations (0-500 μM), mix well, and scan the area with a nuclear magnetic resonance imager. The to-be-scanned area o...

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Abstract

The invention discloses an indocyanine green-phospholipid complex as well as its preparation method and application. The amphiphilic ICG-phospholipid complex prepared in the present invention exhibits good ability to chelate iron ions both in vitro and in vivo. Through this chelation, the ferromagnetic properties and ICG's own spectral properties will be affected, and the amount of active iron in vivo and in vitro can be quantified by detecting the change value of nuclear magnetic resonance signal, fluorescence signal and photoacoustic signal, so as to diagnose iron overload degree of disease. The present invention also relates to that the ICG / phospholipid complex can significantly reduce the iron load of living animals, exhibiting an iron removal effect superior to that of clinically used desferrioxamine (DFO). The ICG and phospholipids used in the present invention are drugs for clinical application, and the complex constructed has strong feasibility for clinical application, so that the amphiphilic ICG-phospholipid complex provides a new solution for the clinical diagnosis and treatment of iron overload diseases.

Description

technical field [0001] The present invention relates to indocyanine green-phospholipid complex and its preparation method and application. Background technique [0002] Iron overload refers to a pathological state caused by abnormal iron metabolism and iron content in the body exceeding normal levels. When the iron content in the body exceeds the binding capacity of transferrin, iron will be deposited in some parts of the body, and a large number of oxidative free radicals will be generated through the Fenton reaction, causing damage to lipids, proteins, and nucleic acids, resulting in damage to the liver, heart, pancreas, and pituitary gland. Structural damage and dysfunction of important parts such as joints and joints are related to liver cancer, anemia, osteoporosis, endometriosis and other diseases. The liver is the most important liver metabolism and storage organ. Liver health status has a very strong influence and is particularly closely related to hepatocellular ca...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K49/00C09K11/06G01N21/64G01N24/08A61K31/685A61K31/403A61P3/00A61K49/22A61K49/06
CPCA61K31/403A61K31/685A61K49/0002A61K49/0034A61K49/06A61K49/22A61P3/00C09K11/06C09K2211/1029G01N21/6402G01N21/6486G01N24/087A61K2300/00
Inventor 刘刚林惠荣
Owner XIAMEN UNIV
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