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A kind of preparation method and application of medicinal compound plant fatty acid calcium

A technology of fatty acid calcium and plants, which is applied in the field of preparation of medicinal compound plant fatty acid calcium, to achieve the effects of improving stability, reducing viscosity, and improving the effect of saponification reaction

Active Publication Date: 2021-01-19
BELIKE CHEM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The invention provides a preparation method and application of medicinal compound plant fatty acid calcium to solve the problem of how to increase the content of polyunsaturated fatty acids

Method used

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  • A kind of preparation method and application of medicinal compound plant fatty acid calcium
  • A kind of preparation method and application of medicinal compound plant fatty acid calcium

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preparation example Construction

[0022] In an embodiment, a preparation method of medicinal compound plant fatty acid calcium comprises the following steps: (1) in parts by weight: 10-14 parts of linseed oil, 8-12 parts of mulberry seed oil, 4-6 parts of Coconut oil, 2-4 parts of citric acid, 3-5 parts of water-soluble starch, 0.2-0.4 parts of micron grade calcium hydroxyphosphate, after mixing evenly, add dropwise 90% ethanol solution of sodium ethylate, heat to reflux state to maintain 2-4 hours; (2) after adding 90% ethanol, filter, after washing the filter cake with 90% ethanol, combine the filtrate; (3) adjust the pH of the filtrate to 3-4 with 10% hydrochloric acid, add milk of lime, shake at room temperature Shake for 1 hour, control the pH value to 8, let it stand for 15 minutes, pour out the turbid solution, filter to obtain ethanol solution and precipitate; (4) Distill the ethanol solution under reduced pressure, remove ethanol, obtain a concentrate, filter off most of Moisture, drying and vacuum dr...

Embodiment 1

[0028] A preparation method of medicinal compound plant fatty acid calcium, comprising the following steps: (1) parts by weight: 12 parts of linseed oil, 10 parts of mulberry seed oil, 5 parts of coconut oil, 3 parts of citric acid, 4 parts of 0.3 parts of micron grade calcium hydroxyphosphate, after mixing evenly, add 162 parts of 90% ethanol solution of 20wt% sodium ethylate dropwise, heat to reflux state and keep for 3 hours; (2) add 90% ethanol 135 After washing the filter cake with 54 parts of 90% ethanol, the filtrate was combined; (3) the filtrate was adjusted to pH=3.6 with 10% hydrochloric acid, added milk of lime, shaken at room temperature for 1 hour, and the pH was controlled to be 8, and left to stand After 15 minutes, pour out the turbid solution and filter to obtain ethanol solution and precipitate; (4) Distill the ethanol solution under reduced pressure to remove ethanol to obtain a concentrate, filter off most of the water, and dry the concentrate at 60°C for 6...

Embodiment 2

[0033] A preparation method of medicinal compound plant fatty acid calcium, comprising the following steps: (1) parts by weight: 14 parts of linseed oil, 8 parts of mulberry seed oil, 6 parts of coconut oil, 2 parts of citric acid, 3 parts of 0.2 parts of micron grade calcium hydroxyphosphate, after mixing evenly, add 168 parts of 90% ethanol solution of 20wt% sodium ethylate dropwise, heat to reflux state and keep for 2.2 hours; (2) add 140 parts of 90% ethanol After that, filter, after washing the filter cake with 56 parts of 90% ethanol, combine the filtrate; (3) adjust the pH of the filtrate to 3.2 with 10% hydrochloric acid, add milk of lime, shake at room temperature for 1 hour, control the pH value to 8, and let stand for 15 Minutes, pour out the turbid solution, filter to obtain ethanol solution and precipitate; (4) distill the ethanol solution under reduced pressure, remove ethanol, obtain a concentrate, filter most of the water, and dry the concentrate at 60°C for 6 h...

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Abstract

The invention discloses a preparation method and an application of medicinal composite plant fatty acid calcium, and belongs to the technical field of biological medicine preparation. The medicinal composite plant fatty acid calcium comprises the following raw materials: linseed oil, mulberry oil, coconut oil, citric acid, water-soluble starch and micron-sized hydroxyl calcium phosphate, and is formed through steps of saponification, filtration, concentration, acidification and calcification. By adopting the method disclosed by the invention, the content and the yield of the polyunsaturated fatty acid are obviously improved. The composite plant fatty acid calcium prepared by the invention can be applied to pharmaceutical adjuvants or auxiliary materials or pharmaceutical products for supplementing calcium for old people.

Description

technical field [0001] The invention belongs to the technical field of biomedicine preparation, and in particular relates to a preparation method and application of medicinal compound plant fatty acid calcium. Background technique [0002] The most common vegetable oils are triglycerides, the fatty acids in which are polyunsaturated fatty acids and saturated fatty acids. Clinical and pharmacodynamic experiments have confirmed that saturated fatty acids and monounsaturated fatty acids in serum are harmful factors that promote thrombus formation in the human body, cause fibrin to accumulate in the blood, and form atherosclerosis. Polyunsaturated fatty acids containing more than two double bonds can adjust the distribution of cholesterol between blood and tissues, promote the esterification of cholesterol, and at the same time be the precursor of prostaglandin synthesis, inhibit platelet aggregation and enhance the activity of fibrinolytic system , is an active factor controll...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C51/41C07C53/126C07C51/48C07C51/47C07C51/42A61K47/12A61P3/14
CPCA61K47/12A61P3/14C07C51/412C07C51/42C07C51/47C07C51/48C07C53/126
Inventor 郭向荣王海
Owner BELIKE CHEM
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