Application of chlorogenic acid, isomer or pharmaceutically acceptable salt in preparation of tumor chemotherapy sensitization drugs

A technology of isomers and chemotherapeutic drugs, which is applied in the application field of preparing tumor chemotherapeutic sensitizing drugs, can solve the problems of low solubility of chlorogenic acid, limit the clinical application of chlorogenic acid, and limit the value of clinical application, so as to reduce the Incidence of toxic and side effects, increased safety and therapeutic effect, and improved therapeutic sensitivity

Pending Publication Date: 2020-08-25
刘玉琳
View PDF4 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the low solubility and poor bioavailability of chlorogenic acid in water, its clinical application value is limited.
In addition, chlorogenic acid molecules contain unstable structures such as ester bonds, polyphenols, and unsaturated double bonds, which can be destroyed by heat and light. The stability is poor and the shelf life is short, which limits the clinical application of chlorogenic acid.
Therefore, the application of chlorogenic acid in tumor treatment is still in the exploratory stage, and the application of drugs in the preparation of chemotherapy sensitization has not been reported yet.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of chlorogenic acid, isomer or pharmaceutically acceptable salt in preparation of tumor chemotherapy sensitization drugs
  • Application of chlorogenic acid, isomer or pharmaceutically acceptable salt in preparation of tumor chemotherapy sensitization drugs
  • Application of chlorogenic acid, isomer or pharmaceutically acceptable salt in preparation of tumor chemotherapy sensitization drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0041] 1. Obtaining chlorogenic acid and its isomers

[0042] Chlorogenic acid and its isomers can be purchased from commercial products or synthesized with reference to previous patents. The compound structures of chlorogenic acid and neochlorogenic acid are as follows: figure 1 Shown (where a is chlorogenic acid, b is neochlorogenic acid, and c is cryptochlorogenic acid). At the same time, in order to enhance the stability and solubility of chlorogenic acid and its isomers, the preparation process (including: pharmaceutical carrier, absorption enhancer) can be used to improve drug stability, improve oral absorption rate, increase target tropism; pharmaceutical carriers include but not limited to microcapsules, microspheres, nanoparticles, liposomes, etc., absorption enhancers include but not limited to cholic acid and its salts (such as sodium deoxycholate), surface active Agents (such as poloxamer), polymer materials (such as carbomer), etc.), improve the bioavailability ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention relates to application of chlorogenic acid, isomer or pharmaceutically acceptable salt in preparation of tumor chemotherapy sensitization drugs, and provides new medical application of chlorogenic acid, isomers or pharmaceutically acceptable salts, namely induction of tumor stem cell differentiation and reduction of biological characteristics of tumor stem cells, and serving as a sensitizer for tumor chemotherapy. The invention is used for improving the treatment sensitivity of chemotherapeutic drugs. According to the present invention, with the combined application of the pharmaceutical composition and the traditional tumor treatment scheme, the use amount of the cytotoxic drug can be significantly reduced so as to reduce the incidence of the toxic-side reaction of the traditional treatment, increase the safety and the treatment effect of the tumor chemotherapy, reduce the enhancement of the tumor dryness caused by the chemotherapy, and enhance the tumor chemotherapy sensitivity.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and relates to the application of chlorogenic acid, isomers or pharmaceutically acceptable salts in the preparation of tumor chemotherapeutic sensitization drugs. Background technique [0002] Chemotherapy is an important means of malignant tumor treatment. It plays an important role in the treatment of digestive tract tumors, lung cancer, triple-negative breast cancer, and gynecological tumors. Clinical conventional chemotherapy regimens, usually based on platinum-based chemotherapy, inhibit tumor progression through cytotoxicity. However, malignant tumors often develop drug resistance, which is a key factor limiting the efficacy of traditional chemotherapy. How to improve the effect of chemotherapy through appropriate sensitization regimens is an important strategy to improve the prognosis of patients with malignant tumors. [0003] Cancer stem cells (CSCs) only account for a very small ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/216A61K45/06A61K33/243A61P35/00
CPCA61K31/216A61K45/06A61K33/243A61P35/00A61K2300/00
Inventor 刘玉琳王强颜泽萱向卓
Owner 刘玉琳
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap