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Soluble microneedle for promoting hair growth and preparation method

A hair growth and soluble technology, applied in the direction of microneedles, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problems of interleukin 2 subcutaneous injection, pain, uneven distribution, and expensive hair transplantation , achieve the effect of shortening the resting period of hair, promoting hair thickening and improving compliance

Pending Publication Date: 2020-08-18
XIEHE HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI & TECH UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The object of the present invention is to provide a soluble microneedle for promoting hair growth and its preparation method, which can solve the problem of low transdermal rate and uneven distribution of existing external drugs, painful subcutaneous injection of interleukin 2, and side effects of oral administration of finasteride. Large, expensive technical issues

Method used

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  • Soluble microneedle for promoting hair growth and preparation method
  • Soluble microneedle for promoting hair growth and preparation method
  • Soluble microneedle for promoting hair growth and preparation method

Examples

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Effect test

preparation example Construction

[0045] A method for preparing hair growth-promoting soluble microneedles, comprising the following steps:

[0046] 1) Mix the PDMS prepolymer and the curing agent at a mass ratio of 10:1 to obtain a mixture, then pour the mixture on the surface of the quadrangular pyramid metal microneedle array mold; then, vacuumize to remove the air bubbles in the mixture, and then heat to make PDMS is solidified; after cooling, the solidified PDMS is separated from the quadrangular pyramid metal microneedle array mold to obtain the PDMS microneedle array mold;

[0047] 2) Uniformly dispersing the hair growth-promoting substance and the soluble polymer into ultrapure water to obtain an aqueous solution of the soluble polymer containing the hair-growth promoting substance;

[0048] 3) Treat the PDMS microneedle array mold obtained in step 1) with oxygen plasma, and then apply the soluble polymer aqueous solution containing hair growth-promoting substances obtained in step 2) on the PDMS micro...

Embodiment 1

[0057] Example 1 Preparation and experiment of dissolvable microneedles loaded with minoxidil

[0058] This embodiment comprises the following steps:

[0059] (1) Preparation of soluble microneedles loaded with minoxidil sulfate

[0060] ① Mix the PDMS prepolymer and the curing agent at a mass ratio of 10:1 to obtain a mixture, and then pour the mixture on the surface of the quadrangular pyramid metal microneedle array template; then, evacuate to -0.08MPa to remove the mixture Then heat and solidify at 80°C for 2 hours to solidify the PDMS; after cooling, separate the solidified PDMS from the quadrangular pyramid metal microneedle array template to obtain the PDMS microneedle array template; wherein, the height of the microneedles is 850 μm, and the bottom The diameter is 400 μm, and the distance between adjacent needle tips is 600 μm;

[0061] 2. Minoxidil sulfate, hyaluronic acid are evenly dispersed in ultrapure water to obtain the hyaluronic acid aqueous solution contain...

Embodiment 2-5

[0074] Example 2-5: Preparation of soluble microneedles for promoting hair growth with different parameters

[0075] (1) According to the method of Example 1, by adjusting the structure of the microneedle positive template and the concentration of the hair growth-promoting substance solution, microneedles with various parameters as shown in Table 1 were obtained.

[0076] Table 1 The amount of materials required to prepare microneedles with different parameters in 5 examples

[0077]

[0078]

[0079] The method of Example 1 of the present invention can be used to prepare soluble microneedles for promoting hair growth with different lengths, base diameters, distances between adjacent needle tips, content of hair growth-promoting substances, soluble polymer content and biosolubilizer content, so as to adapt to different objects demand.

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Abstract

The invention discloses a soluble microneedle for promoting hair growth. The microneedle comprises a base, a soluble polymer needle body located on the base and a needle tip carrying a hair growth promoting substance. The invention discloses a preparation method of a soluble microneedle for promoting hair growth. The preparation method comprises the following steps: 1) preparing a PDMS microneedlearray mold; 2) preparing a soluble polymer aqueous solution containing substances for promoting hair growth; and 3) preparing the soluble polymer microneedle array loaded with the substance for promoting hair growth, which can solve the technical problems of low transdermal rate, non-uniform distribution, pain in the subcutaneous injection process of interleukin 2, large side effect of a finasteride oral administration mode and high hair transplantation price of the existing external medicine.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and more specifically relates to a soluble microneedle for promoting hair growth and a preparation method thereof. Background technique [0002] Many people experience hair loss due to factors such as age and genetics. For example, in androgenetic alopecia, the patient's hair tends to become thinning from the top or both sides of the forehead, and the terminal hair gradually transforms into short, thin, and colorless vellus hair; alopecia areata is very common in the population, and can occur in both men and women. In addition, alopecia areata and hair loss caused by radiotherapy and chemotherapy are not uncommon. While modern people are in social activities, the first impression of each other need not be emphasized is particularly important. Under such circumstances, people spend a lot of time and money on hair management in order to improve their image. [0003] At present, the most commo...

Claims

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Application Information

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IPC IPC(8): A61K38/20A61K31/19A61K31/192A61K31/404A61K31/506A61K31/5375A61K31/573A61K31/575A61K31/58A61K47/36A61M37/00A61P17/14
CPCA61K38/2013A61K31/404A61K31/575A61K31/5375A61K31/192A61K31/506A61K31/58A61K31/573A61K31/19A61K9/0021A61K47/36A61P17/14A61M37/0015A61M2037/0053A61K2300/00
Inventor 陶娟黄玉琼朱锦涛李钰策张连斌朱今巾杜虹瑶
Owner XIEHE HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI & TECH UNIV
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