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A kind of titanium-based active bone implant with composite coating and preparation method thereof

A composite coating and bone implant technology, applied in coating, metal material coating process, prosthesis, etc., can solve the problems of limited research on MSCs recruitment strategy, overcome the shortage of MSCs, promote the formation of new bone, improve The effect of biological activity

Active Publication Date: 2021-10-26
CHONGQING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, studies on recruitment strategies for MSCs using Ti-based materials are limited.

Method used

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  • A kind of titanium-based active bone implant with composite coating and preparation method thereof
  • A kind of titanium-based active bone implant with composite coating and preparation method thereof
  • A kind of titanium-based active bone implant with composite coating and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Fabrication of titanium-based active bone implants with composite coatings

[0040] (1) Add an equimolar amount of Na 2 SiO 3 9H 2 O and Mg(NO 3 ) 2 ·6H 2 After O was dissolved in water respectively, the Mg(NO 3 ) 2 ·6H 2 O solution into Na 2 SiO 3 9H 2 In the O solution, a milky white substance appears, continue to stir for 10 hours and then stand still for 16 hours, alternately filter and wash with ethanol and water for 3 times, then freeze-dry, calcined at 1000°C for 2 hours, grind, and sieve through a 250-mesh sieve to obtain MgSiO 3 micron particles;

[0041] (2) Ultrasonic cleaning of pure titanium with washing powder water, alcohol, deionized water, and alcohol for 15 minutes each, and drying for later use;

[0042] (3) Plasma spraying step (1) on the pure titanium surface treated by step (2) to obtain MgSiO 3 micron particles to obtain MgSiO with a thickness of 90 μm 3 bioceramic layer, followed by MgSiO 3 On the bioceramic layer, spin-coat chitos...

Embodiment 2

[0044] Fabrication of titanium-based active bone implants with composite coatings

[0045] (1) Add an equimolar amount of Na 2 SiO 3 9H 2 O and Mg(NO 3 ) 2 ·6H 2 After O was dissolved in water respectively, the Mg(NO 3 ) 2 ·6H 2 O solution into Na 2 SiO 3 9H 2 In the O solution, a milky white substance appeared, continued to stir for 12 hours, then stood still for 24 hours, alternately filtered and washed with ethanol and water for 4 times, then freeze-dried, calcined at 1200°C for 2 hours, ground, and sieved through a 250-mesh sieve to obtain MgSiO 3 micron particles;

[0046] (2) Ultrasonic cleaning of pure titanium with washing powder water, alcohol, deionized water, and alcohol for 15 minutes each, and drying for later use;

[0047] (3) Plasma spraying step (1) on the pure titanium surface treated by step (2) to obtain MgSiO 3 micron particles to obtain MgSiO with a thickness of 100 μm 3 bioceramic layer, followed by MgSiO 3 On the bioceramic layer, spin-coa...

Embodiment 3

[0049] Fabrication of titanium-based active bone implants with composite coatings

[0050] (1) Add an equimolar amount of Na 2 SiO 3 9H 2 O and Mg(NO 3 ) 2 ·6H 2 After O was dissolved in water respectively, the Mg(NO 3 ) 2 ·6H 2 O solution into Na 2 SiO 3 9H 2 In the O solution, a milky white substance appears, continue to stir for 8 hours and then stand still for 12 hours, alternately filter and wash with ethanol and water for 5 times, then freeze-dry, calcined at 800°C for 3 hours, grind, and sieve through a 250-mesh sieve to obtain MgSiO 3 micron particles;

[0051] (2) Ultrasonic cleaning of pure titanium with washing powder water, alcohol, deionized water, and alcohol for 15 minutes each, and drying for later use;

[0052] (3) Plasma spraying step (1) on the pure titanium surface treated by step (2) to obtain MgSiO 3 Micron particles, to obtain MgSiO with a thickness of 95 μm 3 bioceramic layer, followed by MgSiO 3On the bioceramic layer, spin-coat chitosan...

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Abstract

The invention relates to a titanium-based active bone implant with a composite coating and a preparation method thereof, belonging to the technical field of medical materials. The method is as follows: spray MgSiO on the surface of pure titanium 3 micron particles, to obtain MgSiO 3 bioceramic layer, then the MgSiO 3 On the bioceramic layer, spin-coat chitosan solution, gelatin solution, and neuropeptide P substance solution in turn, and then spin-coat gelatin solution, chitosan solution, gelatin solution, and neuropeptide P substance solution in turn, and then spin-coat gelatin solution in turn. , chitosan solution, gelatin solution, and neuropeptide P substance solution are called a complete spin coating, and the subsequent number of complete spin coatings is determined according to the actual demand release amount of the neuropeptide P substance. After coating, spin coat a layer of gelatin solution. The implant has good biocompatibility, can effectively promote the formation of new bone, and the preparation method is simple and easy to operate, and is suitable for large-scale production.

Description

technical field [0001] The invention belongs to the technical field of medical materials, and in particular relates to a titanium-based active bone implant with a composite coating and a preparation method thereof. Background technique [0002] Often beyond the critical size of bone defects, endogenous repair is limited, especially in complex fractures and diseases where bone grafting is unavoidable. Titanium and titanium alloys are widely used in orthopedics because of their good mechanical properties, corrosion resistance and biocompatibility. However, the bioinertness of pure titanium surfaces limits its osseointegration with surrounding bone tissue and even compromises its long-term implant performance. Furthermore, bone repair is a highly regulated and complex physiological process in which bone-derived mesenchymal stem cells (MSCs) play an integral role. Therefore, it is of great practical significance to further improve the osseointegration performance of titanium-b...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/06A61L27/30A61L27/34A61L27/54C23C4/04C23C4/134C23C4/12C23C24/04
CPCA61L27/06A61L27/306A61L27/34A61L27/54A61L2300/252A61L2300/412A61L2300/602A61L2300/606A61L2430/02C23C4/04C23C4/12C23C24/04C23C4/134C08L89/00C08L5/08
Inventor 胡燕沐彩云蔡开勇罗忠
Owner CHONGQING UNIV
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