Pharmaceutical composition for preventing and treating anxiety caused by alcohol
A composition and drug technology, which is applied in the directions of drug combination, drug delivery, and pharmaceutical formulation, to achieve the effects of high patient compliance, convenient administration, and alleviation of withdrawal reactions.
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Embodiment 1
[0029] Example 1: A chewable tablet for preventing and treating alcohol-induced anxiety
[0030] 10g of 7,8-dihydroxyflavone, 30g of mannitol, 30g of sorbitol, 23g of microcrystalline cellulose, 5g of sodium carboxymethylcellulose, 1g of stevioside, 0.5g of citric acid, 0.5g of lemon essence, and appropriate amount of magnesium stearate , prepared as follows:
[0031] (1) material preparation: take each raw material according to the amount, and cross 60 mesh sieves respectively for subsequent use;
[0032] (2) Mix all the 7,8-dihydroxyflavone, mannitol, sorbitol, microcrystalline cellulose, sodium carboxymethyl cellulose, stevioside, citric acid, and lemon essence, and then add an appropriate amount of water-based soft material, Granulate through a 20-mesh sieve, dry at 50°C for 1-2 hours, add magnesium stearate, mix evenly, and tablet to obtain the chewable tablet for preventing and treating alcohol-induced anxiety of the present invention.
Embodiment 2
[0033] Embodiment 2: A chewable tablet for preventing and treating alcohol-induced anxiety
[0034] Nalmefene hydrochloride 15g, mannitol 40g, sorbitol 20g, microcrystalline cellulose 18g, sodium carboxymethylcellulose 5g, glycyrrhizin 0.8g, citric acid 0.6g, apple essence 0.6g, magnesium stearate Appropriate amount, prepared according to the method of Example 1 to obtain the chewable tablet for preventing and treating alcohol-induced anxiety of the present invention.
Embodiment 3
[0035] Example 3: A chewable tablet for preventing and treating alcohol-induced anxiety
[0036] 7,8-dihydroxyflavone 9g, nalmefene hydrochloride 6g, mannitol 40g, sorbitol 20g, microcrystalline cellulose 18.7g, carboxymethylcellulose sodium 5g, aspartame 0.1g, citric acid 0.6 g, 0.6g of mango essence, appropriate amount of magnesium stearate, prepared according to the method of Example 1 to obtain the chewable tablet for preventing and treating alcohol-induced anxiety of the present invention.
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