Novel endoscopic blood flow imaging and blood flow parameter quantification method and system

Abstract

The invention discloses a novel endoscopic blood flow imaging and blood flow parameter quantification method. The method comprises the steps of blood vessel scanning, interference spectrum forming, data acquisition, imaging processing, parameter quantification and extraction, blood flow image generation and clinical data obtaining. A system for realizing the method consists of a light source, redlight, a circulator, a coupler, a reference arm, an optical rotary motor, an intervention catheter, a data acquisition module and a signal processing module. The system is simple in structure, the method is easy to implement, the precision of obtained data is high, and clinical diagnosis of doctors on diseases is facilitated.

Description

[0001] (1) Technical field: [0002] The present invention relates to the technical field related to medical imaging, in particular to a novel endoscopic blood flow imaging and blood flow parameter quantification method and system. [0003] (two) background technology: [0004] As one of the important means for diagnosing human tissue lesions, optical endoscopic biopsy technology has become a major direction of modern optical technology applications. Traditional optical endoscopy can only observe the surface of internal tissues, while ultrasonic endoscopy can observe the tissue morphology of organ sections, but due to its low resolution, it is often difficult to achieve the resolution level required for accurate diagnosis. [0005] In recent years, in medicine, the technology of diagnosing certain diseases based on blood flow detection has attracted more and more attention from the medical field, such as laser speckle blood flow imaging technology, Doppler OCT (Optical Coherenc...

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Problems solved by technology

[0009] However, in previous studies, due to the low resolution of color Doppler ultrasound, MRI, CT (Computered Tomography, computerized tomography), coronary angiography, intravascular ultrasound and other instruments, it was not possible to observe neovascularization in vulnerable plaques in vivo. , limiting the study of the relationship between neovascularization and plaque vulnerability

Although OCT can observe the composition and microstructure information of the vessel wall and plaque, it cannot obtain the blood perfusion information and blood flow parameter information of the microvascular

In the existing in vivo blood flow imaging methods, non-optical imaging techniques, such as CT, magnetic resonance, PET (PositronEmission Computed Tomography, Positron Emission Computed Tomography, Positron Emission Computed Tomography), etc., have slow imaging speed and low spatial resolution, and cannot Obtain spatiotemporal information of blood perfusion at the level of single capillary

[0010] At present, the OCT used can observe the composition and microstructure information of the vessel wall and plaque, but cannot obtain the blood perfusion information and blood flow parameter information of the microvascular

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