Anti-aging corrective and protective formulation and methods

A formulation and functionalization technology, applied in the direction of cosmetic preparations, skin care preparations, cosmetics, etc., can solve complex problems

Pending Publication Date: 2020-08-04
JAMRM LLC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Factors in the surrounding environment that have an adverse effect on the skin complicate

Method used

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  • Anti-aging corrective and protective formulation and methods
  • Anti-aging corrective and protective formulation and methods
  • Anti-aging corrective and protective formulation and methods

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0055] Using MelanoDerm TM 3D Tissue Analyzer conducts in vitro tests to determine whether an innovative anti-aging formulation reduces melanin concentration in skin tissue. A comparative test was performed against a test serum comprising 30 wt.% THD ascorbate. The experiment was a 14-day test, in which the tissue was rinsed with phosphate-buffered saline (PBS) solution every 24 hours, and fresh material (test serum or innovative anti-aging formulation) was applied, and the medium was also changed. After 14 days, tissues were homogenized and digested to determine melanin content. The melanin content of the tissue was determined in μg melanin / tissue.

[0056] figure 1 Results are shown in bar graphs. In untreated tissues, melanin increased to nearly 30 μg / tissue. In the case of treatment of the tissue with a comparative test serum containing THD ascorbate, the melanin was about 26 μg / tissue. In the case of treating the tissue with the exemplary anti-aging formulation of ...

example 2

[0059]In order to assess the levels of glutathione, a skin lightening agent, in samples treated with exemplary embodiments of the inventive formulations versus untreated samples, an in vitro test was performed. Intracellular levels of the small molecular weight antioxidant glutathione were determined in HaCaT keratinocytes after 24 hours of incubation with exemplary embodiments of anti-aging formulations, compared to negative controls (untreated). figure 2 It is shown that after 24 hours, the level of glutathione has been upregulated by 49%, from 1.51 (nM / μg protein) to 2.25 (nM / μg protein).

example 3

[0061] To determine the degree of protection provided against reactive oxygen species (ROS) generated by high energy visible (HEV) light (also known as blue light) in the 450 nm range, tests were performed. Use MatTek TM EpiDerm TM organization for these in vitro tests.

[0062] Exposure to blue light induces skin aging effects including intractable hyperpigmentation, synthesis of melanin, and generation of free radicals such as ROS. Accordingly, measuring the amount of reactive oxygen species formed and determining whether an anti-aging formulation prevents ROS formation is very capable of examining its efficacy in vitro.

[0063] image 3 There is a bar graph showing the percentage of reactive oxygen species (ROS) formed when exposed to blue light for periods of 30 minutes, 60 minutes and 120 minutes. In terms of the percentage of reactive oxygen species, the samples treated with the exemplary anti-aging formulation were very close to the samples not exposed to blue lig...

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Abstract

There are presented topical formulations and methods of applying these formulations in therapeutically effective amounts directly to areas of the human skin to remediate and to counter effects that are commonly regarded as aging. The formulations address the effects on the skin of UV light, High Energy Visible (HEV) light, blue light, and Urban Dust as well as remediating fine lines and age-related localized melanin concentrations ("age spots"), improving the uniformity of skin tone (reduction in skin redness) and enhancing the brightness of the skin to provide a more youthful appearance. Skintreated with the formulations also exhibit a reduction in the depth and prominence of wrinkles, a marked reduction in harmful reactive oxygen species in the treated skin, and a reduction in lipid peroxidation caused by Urban Dust.

Description

technical field [0001] The present invention relates to formulations for treating the effects of aging and environmental factors on human skin, and more particularly, formulations which are applied topically and have an anti-aging effect and also provide the effect of protecting the skin and correcting existing skin damage. Background technique [0002] Human skin is a multilayered tissue often referred to as the "largest organ of the body". Human skin is complex both structurally (multilayered with varying porosity and fed by numerous blood vessels) and in terms of its biochemistry and biome. Factors in the surrounding environment which have an adverse effect on the skin lead to further complications. [0003] It has been recognized that the visible appearance and texture of a person's skin changes over the years as the person ages. And, over the ages, people have attempted to minimize these changes in appearance and texture, or to reverse these age-induced changes, with ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/68A61K8/67A61K8/64A61K8/60A61K8/58A61K8/46A61Q19/00A61Q19/08
CPCA61K8/676A61K8/46A61K8/602A61K8/64A61K8/585A61K8/671A61K8/678A61K8/673A61K8/68A61K8/60A61Q19/08A61Q19/004A61Q19/00A61K36/68A61K36/9068A61K8/35A61K8/9789A61K36/30A61K2300/00A61K8/042A61K8/062A61K8/064A61K8/97A61K8/9783A61K8/066
Inventor 塔蒂安娜·凯利阿里萨·萨拉赫·扎赫尔丽塔·迪西阿纳·卡布雷拉约翰·科赫特雷莎·福克斯尼马尔·沙赫
Owner JAMRM LLC
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