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Preparation method for robustaside b in sparrow beak tea, and application of robustaside b for treating hyperuricemia

A technology of oujinin and sparrow mouth tea, applied in the field of medicine, can solve the problems of anti-hyperuricemia and related diseases that have not been reported yet

Pending Publication Date: 2020-07-31
HUAQIAO UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the patents related to oujinin that have been seen so far mainly focus on the preparation method and detection method of oujinin, and its role in the preparation of anti-hyperuricemia and related diseases has not been reported yet.

Method used

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  • Preparation method for robustaside b in sparrow beak tea, and application of robustaside b for treating hyperuricemia
  • Preparation method for robustaside b in sparrow beak tea, and application of robustaside b for treating hyperuricemia
  • Preparation method for robustaside b in sparrow beak tea, and application of robustaside b for treating hyperuricemia

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Experimental program
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Embodiment 1

[0031] Preparation of oujinin

[0032] Step 1, take 5 kg of dried sparrow mouth tea as a raw material, pulverize it with a pulverizer, add 50 L and 60% ethanol to soak three times, filter under reduced pressure after each soak, and combine the recovered filtrates to obtain 2.32 kg of extract;

[0033] Step 2, then dissolve the extract of the extract in 8L distilled water to form a suspension, extract with 8L ethyl acetate solvent, mix well and let it stand overnight after contacting, take the upper ethyl acetate layer after layering, and the lower layer The water layer was continuously added with an equal volume of ethyl acetate for extraction, and after repeated extraction three times, the collected ethyl acetate layers were combined to obtain 0.76 kg of ethyl acetate extract and 1.36 kg of water layer sample;

[0034] Step 3. Then heat and dissolve the water layer sample with 3L of methanol, add 2kg of 200-300 mesh column chromatography silica gel and mix evenly, dry and gri...

Embodiment 2

[0040] Uginin reduces serum uric acid (UA) level in hyperuricemia model mice

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Abstract

The invention discloses a preparation method for robustaside b in sparrow beak tea, and application of the robustaside b for treating hyperuricemia. The invention discloses a preparation method for the robustaside b in the sparrow beak tea. A monomeric compound, i.e., the robustaside b, can be obtained through directional extraction and separation in the sparrow beak tea, and an approach for obtaining the robustaside b is provided. The invention also discloses the application of the robustaside b for treating the hyperuricemia, i.e., a new purpose of the robustaside b for treating the hyperuricemia. The invention provides a new medicine precursor, preparation method and medical purpose for the robustaside b to treat the hyperuricemia and related diseases.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a method for preparing oujinin from sparrow beak tea and the application of ouginin in anti-hyperuricemia. Background technique [0002] At present, hyperuricemia is a metabolic disease caused by increased uric acid synthesis and / or decreased uric acid excretion. It refers to fasting blood uric acid levels higher than 420 μmol / L on two different days under a normal purine diet. A Meta-analysis was conducted on the prevalence of hyperuricemia in the Chinese population, and the results showed that the prevalence of hyperuricemia in Chinese males and females was 21.6% and 8.6%, respectively, and the total prevalence was 13.3%. 130 million. [0003] Gout is strongly associated with obesity, chronic kidney disease, hypertension, type 2 diabetes, dyslipidemia, heart disease (including coronary heart disease, heart failure, and atrial fibrillation), stroke, and peripheral ...

Claims

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Application Information

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IPC IPC(8): C07H15/203C07H1/08A61P19/06A61P13/12
CPCC07H15/203C07H1/08A61P19/06A61P13/12
Inventor 刘接卿凌琳连晨蕾李招发马俊杰吴四海米雪
Owner HUAQIAO UNIVERSITY
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