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Application of glutathione in improving water solubility of flavonoid compounds, flavonoid compound co-crystal and preparation method of flavonoid compound eutectic co-crystal

A technology of flavonoids and glutathione, applied in the field of drug co-crystals, can solve problems such as reducing oral bioavailability

Pending Publication Date: 2020-07-31
HEBEI UNIVERSITY OF SCIENCE AND TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Aiming at the technical problem that flavonoids are poorly soluble or insoluble in water and reduce their oral bioavailability, the invention provides the application of glutathione in improving the water solubility of flavonoids

Method used

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  • Application of glutathione in improving water solubility of flavonoid compounds, flavonoid compound co-crystal and preparation method of flavonoid compound eutectic co-crystal
  • Application of glutathione in improving water solubility of flavonoid compounds, flavonoid compound co-crystal and preparation method of flavonoid compound eutectic co-crystal
  • Application of glutathione in improving water solubility of flavonoid compounds, flavonoid compound co-crystal and preparation method of flavonoid compound eutectic co-crystal

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Embodiment 1

[0029] This embodiment provides a kind of rutin-glutathione co-crystal, its preparation method is:

[0030] Accurately weigh 6.1g of rutin (0.01mol) and 3.07g of glutathione (0.01mol) into a mortar, add 0.40g of methanol, grind at 22-28°C for 15 minutes, and dry to obtain rutin-glutathione Glycopeptide co-crystal powder. After inspection, the obtained product is a eutectic crystal structure of triclinic crystal, with a yield of 83.03% and a solubility of 643.29g / L.

Embodiment 2

[0032] This embodiment provides a kind of rutin-glutathione co-crystal, its preparation method is:

[0033] Accurately weigh 6.1g of rutin (0.01mol) and 6.14g of glutathione (0.02mol) into a mortar, add 0.40g of ethanol, grind at 22-28°C for 20 minutes, and dry to obtain rutin-glutathione Glycopeptide co-crystal powder. After inspection, the obtained product is a eutectic crystal structure of triclinic crystal, with a yield of 79.64% and a solubility of 535.75g / L.

Embodiment 3

[0035] This embodiment provides a kind of rutin-glutathione co-crystal, its preparation method is:

[0036] Accurately weigh 6.1g of rutin (0.01mol) and 4.61g of glutathione (0.015mol) into a mortar, add 0.40g of acetonitrile, grind at 22-28°C for 30 minutes, and dry to obtain rutin-glutathione Glycopeptide co-crystal powder. After inspection, the obtained product is a mixture of two eutectics whose crystal structures are all triclinic, with a yield of 75.58% and a solubility of 584.29g / L.

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Abstract

The invention belongs to the technical field of pharmaceutical co-crystals, and particularly relates to an application of glutathione in improving water solubility of flavonoid compounds, a flavonoidcompound co-crystal and a preparation method of the flavonoid compound co-crystal. The flavonoid compounds are quercetin, myricetin, baicalein, chrysin, naringenin or rutin. The flavonoid compound co-crystal is obtained by jointly grinding the flavonoid compounds and glutathione under specific temperature and time conditions, water solubility of the flavonoid compounds can be greatly improved through the obtained flavonoid compound co-crystal, and then oral bioavailability of the flavonoid compounds is improved.

Description

technical field [0001] The invention belongs to the technical field of drug co-crystals, and in particular relates to the application of glutathione in improving the water solubility of flavonoid compounds, a flavonoid compound co-crystal and a preparation method thereof. Background technique [0002] Flavonoids are a class of compounds that widely exist in plants in nature, and play an important role in plant growth, development, flowering, fruiting, antibacterial and disease prevention. Flavonoids have high medicinal value as human medicine, such as preventing and treating cardiovascular and cerebrovascular diseases, relieving cough, eliminating phlegm, relieving asthma, antibacterial, protecting liver, detoxifying liver, anti-tumor, etc., and can also improve the body's antioxidant and The ability to scavenge free radicals and improve the body's immune function. In animal husbandry, flavonoids can significantly improve animal production performance, disease resistance, a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61K31/352C07H17/07C07D311/30C07D311/32C07H1/00A61P39/06C07K5/037C07K1/30A61K38/06
CPCA61K31/7048A61K31/352C07H17/07C07D311/30C07D311/32C07H1/00A61P39/06C07K5/0215A61K38/063C07K2299/00
Inventor 韩雪李冲陶清泉刘新明王成祥李研东郝建雄赵丹丹胡高爽饶欢刘志勤刘慧宫彬彬
Owner HEBEI UNIVERSITY OF SCIENCE AND TECHNOLOGY
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