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A kind of unc5d mutant gene that affects pig hair follicle development and its application

A technique for mutating genes and hair follicles, applied in the field of UNC5D mutation genes that affect the development of pig hair follicles, can solve the problems of unclear function of UNC5D, achieve accurate results and reduce false positives

Active Publication Date: 2021-09-21
CHINA AGRI UNIV
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AI Technical Summary

Problems solved by technology

Although we have previously found that p53 directly targets the expression of UNC5D, the specific role of UNC5D function is still unclear

Method used

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  • A kind of unc5d mutant gene that affects pig hair follicle development and its application
  • A kind of unc5d mutant gene that affects pig hair follicle development and its application
  • A kind of unc5d mutant gene that affects pig hair follicle development and its application

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Experimental program
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Embodiment Construction

[0019] Step 1: A small number of hairless pigs were expanded according to the breeding theory, and 12 boar families containing hairless individuals were established. A total of 120 Large White pigs from the same field were collected, including 60 hairless individuals and 60 normal individuals; in preparation for later phenotypic verification and screening of candidate genes for hairless traits.

[0020] Step 2: Taking 19-day-old piglets as the research object (the comparison between hair shaft and follicle of hairless and normal pigs is the most obvious), measure the unit area (cm 2 ) hair shaft number. Detect the number of hair shafts on the same part of the back, and judge the pigs with the number of hair shafts less than or equal to 3 (mean + standard deviation) per square centimeter as hairless pigs, and those with more than or equal to 6 hair shafts (mean - standard deviation) as hairless pigs normal pig. At the same time, the back tissue was cut transversely and longit...

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Abstract

The invention relates to a UNC5D mutant gene affecting the development of pig hair follicles and its application. The UNC5D mutant gene that affects the development of pig hair follicles provided by the present invention has 7 mutation sites, and its physical location is between 50201782 and 50441773 of pig chromosome 15, and its nucleotide sequence is shown in SEQ ID NO: 1-4 . The invention finds out the key gene of pig hairless trait, and provides important reference and animal model for the research of human hereditary alopecia through the analysis and research of the hairless trait. Using the UNC5D mutant gene of the present invention to carry out assisted breeding of pigs can effectively select sows with stable genetic hairless traits, and then can realize short-term, low-cost, high-accuracy selection of excellent disease model pigs , and secondly, it can also be used as a molecular marker for identification of hereditary alopecia, and can be further applied to the study of hair development in mammals.

Description

technical field [0001] The invention relates to the field of molecular biology and medicine, in particular to a UNC5D mutation gene affecting pig hair follicle development and its application. Background technique [0002] Humans are very concerned about hereditary hair loss and hair thinning, and the stability of hair follicle morphology and function is the key to a normal hair cycle. The morphological structure and function of hair follicles are congenital. People have done a lot of research on the genetic mechanism of hair follicles, hoping to solve the problem of hair loss from the source. Pigs are of great significance in medicine. The genetic homology between pigs and humans is very high. Their genomes are similar to those of humans, and their complexity and chromosomal composition are also relatively consistent. The conservation of syntenic regions between humans and pigs is similar to that between humans and mice. 3 times. Therefore, pigs are now used as ideal mode...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12Q1/6888C12N15/11
CPCC12Q1/6888C12Q2600/124C12Q2600/156
Inventor 丁向东蒋尧梅孟然
Owner CHINA AGRI UNIV
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