Polyhydric alcohol glucoside, and preparation method and application thereof

A technology of glucoside and polyol, which is applied in the preparation of sugar derivatives, chemical instruments and methods, sugar derivatives, etc., can solve the problems of skin irritation, solvent residue, heavy metal ion residue, etc., and achieve simple reaction steps and conditions, No chemical solvent residue effect

Pending Publication Date: 2020-07-17
福建莲珂科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These methods have certain technical defects, such as solvent residues and heavy metal ion residues, which are irritating to the skin

Method used

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  • Polyhydric alcohol glucoside, and preparation method and application thereof
  • Polyhydric alcohol glucoside, and preparation method and application thereof
  • Polyhydric alcohol glucoside, and preparation method and application thereof

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preparation example Construction

[0018] The present invention also relates to a preparation method of a class of polyol glucoside, comprising the following steps:

[0019] Step 1: Add 1,3 propylene glycol or 1,3 butanediol and glucose into the reactor, and heat until the glucose is completely dissolved;

[0020] Step 2: After the glucose is completely dissolved, add the acidic catalyst into the reactor, keep the temperature at 95°C-120°C, and carry out the decompression reaction at 0.08Mp;

[0021] Step 3: After 6 hours of reaction, the condenser no longer separates water, and the reaction is completed. Add an acid neutralizer into the reactor to adjust the pH value of the reaction system in the reactor to 4.5-6.5, and cool to 15-30°C. Produce 1,3 propanediol glucoside or 1,3 butanediol glucoside.

[0022] Preferably, in the step 1 of the above-mentioned preparation method of polyol glucoside, the molar ratio of 1,3 propanediol or 1,3 butanediol to glucose is 10:1˜2:1.

[0023] Preferably, in the step 1 of ...

Embodiment 1

[0030] Weigh 40g of glucose and 160g of 1,3-butanediol (the molar ratio of 1,3-butanediol to glucose is 8:1), put them into the reactor, turn on the heating temperature at 95°C, wait until the glucose is completely dissolved, and pour into the reactor Add 0.1N concentrated sulfuric acid, turn on the vacuum to carry out the decompression reaction, adjust the pH of the system to 4.5 with 0.3% sodium hydroxide after the reaction is completed, distill off excess 1,3 butanediol with a thin film evaporator, and cool to 15°C 52 g of 1,3-butanediol glucoside was obtained with a yield of 92.8%.

Embodiment 2

[0032] Weigh 50g of glucose and 150g of 1,3-butanediol (the molar ratio of 1,3-butanediol to glucose is 6:1), put them into the reactor, turn on the heating temperature of 110°C, wait until the glucose is completely dissolved, and pour into the reactor Add 0.15N p-toluenesulfonic acid, turn on the vacuum to carry out the decompression reaction, adjust the pH of the system to 5.2 with 0.25% potassium hydroxide after the reaction, distill off the excess 1,3 butanediol with a thin film evaporator, and cool to At 25°C, 67 g of 1,3-butanediol glucoside was obtained, with a yield of 95.7%.

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PUM

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Abstract

The invention relates to the technical field of cosmetics and medicines, and in particular relates to polyol glucoside, and a preparation method and application thereof. By preparing a series of compounds with a moisturizing function, the obtained moisturizing compounds can be used for preparing cosmetic reagents or pharmaceutical reagents, and the cosmetic reagents and the pharmaceutical reagentsare not specifically limited. For example, the cosmetic reagents can be a smoothing toner, a nutritional toner, massage cream, an emollient, a gel, nutritional cream, a mask, a gel or washing type cosmetics such as shower gel and shampoo, and the pharmaceutical reagents can be cream, ointment, cream, plaster or spray and other similar pharmaceutical preparation products. The polyol glucoside canbe used for sensitive skins, and can be added into infant and child cosmetics to reduce irritation.

Description

technical field [0001] The invention relates to the technical field of cosmetics, in particular to a class of polyol glucoside and its preparation method and application. Background technique [0002] Studies have found that polyol glucoside compounds are more moisturizing than traditional moisturizers (such as glycerin), and can effectively improve the symptoms of itching and scaling caused by dry skin after application. It has very little irritation to the human body (eyes, skin), and can relieve the irritation of other substances to the human body when it is compatible; it has good biodegradability; it has excellent ecological and toxicological properties such as sterilization and enzyme activity improvement. [0003] Common polyol glucoside compounds include ethylene glycol glucoside, glycerol glucoside, etc. Conventional preparation methods in the prior art include: direct glycoside method, solvent method, transglycoside method, indirect synthesis method or enzyme cata...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H15/04C07H1/00A61K8/60A61Q19/00
CPCA61K8/602A61Q19/00C07H1/00C07H15/04
Inventor 吴峰肖永堂
Owner 福建莲珂科技有限公司
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