Hepatic stellate cell targeted magnetic resonance molecular imaging agent capable of assessing liver fibrosis degree and preparation method of hepatic stellate cell targeted magnetic resonance molecular imaging agent

Abstract

The present invention discloses a hepatic stellate cell targeted magnetic resonance molecular imaging agent capable of assessing liver fibrosis degree and a preparation method of the hepatic stellatecell targeted magnetic resonance molecular imaging agent, and belongs to the technical field of medicine and biological imaging. The hepatic stellate cell targeted magnetic resonance molecular imagingagent can specifically target hepatic stellate cells by coupling retinol molecules and AKT inhibitors to detect degree and development liver fibrosis process. The hepatic stellate cell targeted magnetic resonance molecular imaging agent is characterized in that the coupled retinol has a magnetic resonance imaging function, at the same time, the coupled AKT inhibitors have a function of treating liver fibrosis, and a purpose of integration of diagnosis and treatment is reached. The hepatic stellate cell targeted magnetic resonance molecular imaging agent is characterized by being high in imaging sensitivity.

Description

technical field [0001] The invention belongs to the technical field of medicine and biological imaging, and in particular relates to a hepatic stellate cell-targeted magnetic resonance molecular imaging agent capable of evaluating the degree of liver fibrosis and a preparation method thereof. Background technique [0002] Liver fibrosis and cirrhosis are common chronic progressive liver diseases, which are a repair response of the liver to chronic damage. Various cytokines secreted by damaged hepatocytes and activated Kupffer cells can lead to the activation of hepatic stellate cells (HSCs) into myofibroblasts, and the activated stellate cells synthesize and secrete a large amount of collagen-based extracellular The matrix is ​​deposited in the liver, leading to the generation of liver fibrosis, which can further develop into cirrhosis. [0003] Hepatic fibrosis is chronic injury leading to excessive deposition of extracellular matrix (ECM) in the liver, and hepatic stellat...

AI Technical Summary

Problems solved by technology

However, liver biopsy is invasive and can cause corresponding complications, so it is not generally accepted by patients, which causes a large proportion of patients with chronic liver disease to delay diagnosis and treatment; at the same time, in asymptomatic patients, Difficulty repeating liver biopsies, which prevents accurate follow-up of changes in patients with chronic liver disease; in addition, sample sampling errors and inconsistencies in pathological observations affect the accuracy of liver biopsies

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