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Application and detection method of protein TNFAIP8 in plasma small extracellular vesicles

A detection method and small cell technology, applied in the field of biomedicine, can solve the problems of undiscovered patent publications, etc., and achieve the effect of timely diagnosis and broad application prospects.

Pending Publication Date: 2020-07-10
天津医科大学眼科医院
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] Through the search, no patent publications related to the patent application of the present invention have been found

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  • Application and detection method of protein TNFAIP8 in plasma small extracellular vesicles
  • Application and detection method of protein TNFAIP8 in plasma small extracellular vesicles
  • Application and detection method of protein TNFAIP8 in plasma small extracellular vesicles

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Embodiment Construction

[0038] The embodiments of the present invention will be described in detail below. It should be noted that the embodiments are illustrative, not restrictive, and cannot limit the protection scope of the present invention.

[0039] The raw materials used in the present invention, unless otherwise specified, are conventional commercially available products; the methods used in the present invention, unless otherwise specified, are conventional methods in the art.

[0040] Use of the protein TNFAIP8 in plasma small extracellular vesicles as a marker for the diagnosis of proliferative diabetic retinopathy.

[0041] Application of the protein TNFAIP8 in plasma small extracellular vesicles as a target for the preparation of drugs for treating diabetic retinopathy.

[0042] The extraction steps of the protein TNFAIP8 in the plasma small extracellular vesicles can be as follows:

[0043] Take the diabetic plasma and centrifuge at 2000g×15min, extract the supernatant and transfer it i...

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Abstract

The invention relates to application of a protein TNFAIP8 in plasma small extracellular vesicles as a marker for diagnosis of proliferative diabetic retinopathy. According to the invention, the protein expression level of TNFAIP8 in plasma sEVs is discovered to be closely related to diabetic retinopathy for the first time; TNFAIP8 expression in plasma sEVs of a diabetic patient is detected and thus whether a subject has the risk of diabetic retinopathy or not can be judged more accurately and quickly, so that a prevention or treatment scheme is provided for clinicians; the protein TNFAIP8 is used as a target for preparing a medicine for treating diabetic retinopathy; a new treatment target and a new treatment way are provided for treating diabetic retinopathy. Compared with the traditionaldetection means, the provided technical scheme enables the diagnosis of the molecular biomarker to be more timely and specific, so that the retinopathy processes of diabetic patients are predicted, early intervention and treatment are carried out, and the application prospect is wide.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, in particular to an application and detection method of protein TNFAIP8 in plasma small extracellular vesicles. Background technique [0002] Diabetic retinopathy (Diabetic retinopathy, DR) has an insidious onset and no obvious symptoms in the early stage. When patients see a doctor, the disease often progresses to the proliferative stage, which is called proliferative diabetic retinopathy (PDR). Current treatments such as laser photocoagulation, Intravitreal injection of anti-vascular endothelial growth factor (VEGF) drugs and vitreoretinal surgery are mainly aimed at patients with advanced stage, and can only restore and maintain partial vision, and it is difficult to reverse the structural and functional damage of the retina. Diagnosis and timely treatment are critical to disease control and prognosis. However, there is still a lack of effective biomarkers as risk factors for the onset of...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/68G01N33/58G01N33/543
CPCG01N33/6893G01N33/581G01N33/543G01N2800/042G01N2800/164G01N2800/50G01N2333/47G01N2500/00
Inventor 李筱荣张晓敏肖静张慧杨付花
Owner 天津医科大学眼科医院
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