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Self-degradable sustained-release material for cardiovascular stent coating and preparation method of sustained-release material

A slow-release material and cardiovascular technology, applied in coating, medical science, surgery, etc., can solve the problems of expensive catalyst and high preparation cost, reduce pain and economic burden, high preparation efficiency, and good controllable degradation effect. Effect

Inactive Publication Date: 2020-07-10
CHENGDU ZHIA TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the preparation of this polymer requires the use of metal complex catalysts, which are generally expensive, making the preparation cost higher

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] A slow-release material for self-degrading cardiovascular stent coating, characterized in that it comprises the following components in parts by weight: 2,5-bischloromethyl-1,3,4-oxadiazole / 30 parts of 2,6-diaminopurine nucleoside polycondensate, 20 parts of hyperbranched polyamino acid, and 2 parts of 1,4-cyclohexanedimethanol bis(3,4-epoxycyclohexanecarboxylate).

[0026] The preparation method of the 2,5-bischloromethyl-1,3,4-oxadiazole / 2,6-diaminopurine nucleoside polycondensate is characterized in that it comprises the following steps: 2,5-bis Chloromethyl-1,3,4-oxadiazole, 2,6-diaminopurine nucleoside, and basic catalyst were added to the high boiling point solvent, stirred and reacted at 40°C for 3 hours, and then precipitated in water, and The solvent is removed by rotary evaporation to obtain 2,5-bischloromethyl-1,3,4-oxadiazole / 2,6-diaminopurine nucleoside polycondensate; the 2,5-bischloromethyl-1, The mol ratio of 3,4-oxadiazole, 2,6-diaminopurine nucleosid...

Embodiment 2

[0032] A slow-release material for self-degrading cardiovascular stent coating, characterized in that it comprises the following components in parts by weight: 2,5-bischloromethyl-1,3,4-oxadiazole / 33 parts of 2,6-diaminopurine nucleoside polycondensate, 22 parts of hyperbranched polyamino acid, and 3 parts of 1,4-cyclohexanedimethanol bis(3,4-epoxycyclohexanecarboxylate).

[0033] The preparation method of the 2,5-bischloromethyl-1,3,4-oxadiazole / 2,6-diaminopurine nucleoside polycondensate is characterized in that it comprises the following steps: 2,5-bis Chloromethyl-1,3,4-oxadiazole, 2,6-diaminopurine nucleoside, and basic catalyst were added to the high boiling point solvent, stirred and reacted at 45°C for 3.5 hours, and then precipitated in water, and The solvent is removed by rotary evaporation to obtain 2,5-bischloromethyl-1,3,4-oxadiazole / 2,6-diaminopurine nucleoside polycondensate; the 2,5-bischloromethyl-1, The mol ratio of 3,4-oxadiazole, 2,6-diaminopurine nucleos...

Embodiment 3

[0039] A slow-release material for self-degrading cardiovascular stent coating, characterized in that it comprises the following components in parts by weight: 2,5-bischloromethyl-1,3,4-oxadiazole / 35 parts of 2,6-diaminopurine nucleoside polycondensate, 25 parts of hyperbranched polyamino acid, 3.5 parts of 1,4-cyclohexanedimethanol bis(3,4-epoxycyclohexanecarboxylate).

[0040] The preparation method of the 2,5-bischloromethyl-1,3,4-oxadiazole / 2,6-diaminopurine nucleoside polycondensate is characterized in that it comprises the following steps: 2,5-bis Chloromethyl-1,3,4-oxadiazole, 2,6-diaminopurine nucleoside, and basic catalyst were added to the high boiling point solvent, stirred and reacted at 50°C for 4 hours, and then precipitated in water, and The solvent is removed by rotary evaporation to obtain 2,5-bischloromethyl-1,3,4-oxadiazole / 2,6-diaminopurine nucleoside polycondensate; the 2,5-bischloromethyl-1, The molar ratio of 3,4-oxadiazole, 2,6-diaminopurine nucleoside,...

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PUM

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Abstract

The invention discloses a self-degradable sustained-release material for a cardiovascular stent coating. The material is characterized by being prepared from the following components in parts by weight: 30 to 40 parts of 2,5-dichloromethyl-1,3,4-oxadiazole / 2,6-diaminopurine nucleoside polycondensate, 20 to 30 parts of hyperbranched polyamino acid and 2 to 5 parts of 1,4-cyclohexanedimethanol bis(3,4-epoxycyclohexane carboxylate). The invention further discloses a preparation method of the self-degradable sustained-release material for the cardiovascular stent coating. The self-degradable sustained-release material for the cardiovascular stent coating is good in sustained-release effect and fine in controllable degradation effect, can perform accurate drug delivery to a to-be-treated part in a blood vessel, effectively improves the treatment efficiency, reduces the death rate, and relieves the pain and economic burden of a patient.

Description

technical field [0001] The invention relates to the technical field of medical materials, in particular to a slow-release material for self-degradable cardiovascular stent coating and a preparation method thereof. Background technique [0002] In recent years, with the accelerated pace of life, increased pressure from life and work, and increasingly severe environmental problems, more and more people suffer from cardiovascular diseases, which have brought great suffering to patients , so that their quality of life is significantly reduced, how to prescribe the right medicine for cardiovascular disease, and rational treatment is very important to alleviate the pain of patients and improve their survival rate and quality of life. [0003] Cardiovascular stent surgery is a common method for the treatment of coronary heart disease and other cardiovascular diseases. It is a new technology to improve myocardial blood supply insufficiency and cardiac artery blockage caused by coron...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/08A61L31/10A61L31/14
CPCA61L31/08A61L31/10A61L31/14A61L31/148C08L77/00
Inventor 向兴力
Owner CHENGDU ZHIA TECH CO LTD
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