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Environment-friendly and efficient levodopa production method

A technology of levodopa and its production method, which is applied in the field of medicine, can solve problems such as high pressure on environmental protection and unqualified environmental assessment of manufacturers, and achieve the effects of saving energy, reducing production operations, and improving extraction efficiency

Active Publication Date: 2020-07-03
GUANGXI UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In the current production process, a large amount of waste water is generated in the steps of column loading, column washing and column regeneration. Generally, for every 1 kg of levodopa produced, 1 to 2 tons of waste water containing high starch, protein, HCl and NaOH will be produced, which poses pressure on environmental protection. Many manufacturers are facing shutdown due to unqualified environmental assessment

Method used

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  • Environment-friendly and efficient levodopa production method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] An environment-friendly and efficient production method for levodopa, comprising the following steps:

[0039] (1) Pretreatment: take dry cat beans with complete granules, add ethanol with a volume fraction of 85% by 4 times the weight of cat beans, reflux heating for 2 hours, and drain the ethanol after cooling for use;

[0040] (2) Add 10 times the amount of solution A, dynamically extract for 9 hours, and retain the extract;

[0041] (3) Add 12 times the amount of solution B or the extract obtained in step (5), perform dynamic extraction for 6 hours, and retain the extract;

[0042] (4) Extract with 10 times the amount of solution B, dynamically extract for 9 hours, and retain the extract;

[0043] (5) leaching with 12 times the amount of solution B, dynamic extraction for 6 hours, and the obtained leaching solution is used as the leaching solution of step (3) in the next production;

[0044] (6) Combine the three leaching solutions of steps (2) to (4), concentrate...

Embodiment 2

[0050] An environment-friendly and efficient production method for levodopa, comprising the following steps:

[0051] (1) Pretreatment: take dry cat beans with complete granules, add ethanol with a volume fraction of 6 times the weight of cat beans and 100% ethanol, reflux heating for 0.5 hours, and dry the ethanol after cooling for use;

[0052] (2) Add 9 times the amount of solution A, dynamically extract for 6 hours, and retain the extract;

[0053] (3) Add 10 times the amount of solution B or the leaching solution obtained in step (5), perform dynamic extraction for 3 hours, and retain the leaching solution;

[0054] (4) leaching with 8 times the amount of solution B, dynamic extraction for 9 hours, and retaining the leaching solution;

[0055] (5) leaching with 15 times the amount of solution B, dynamic extraction for 9 hours, and the obtained leaching solution is used as the leaching solution of step (3) in the next production;

[0056] (6) Combine the three leaching s...

Embodiment 3

[0062] An environment-friendly and efficient production method for levodopa, comprising the following steps:

[0063] (1) Pretreatment: Take dry cat beans with complete granules, add ethanol with a volume fraction of 75% 8 times the weight of cat beans, reflux heating for 1.5 hours, and drain the ethanol after cooling for use;

[0064] (2) Add 8 times the amount of solution A, dynamically extract for 3 hours, and retain the extract;

[0065] (3) Add 15 times the amount of solution B or the leaching solution obtained in step (5), perform dynamic extraction for 9 hours, and retain the leaching solution;

[0066] (4) leaching with 10 times the amount of solution B, dynamic extraction for 3 hours, and retaining the leaching solution;

[0067] (5) leaching with 10 times the amount of solution B, dynamic extraction for 8 hours, and the obtained leaching solution is used as the leaching solution of step (3) in the next production;

[0068] (6) Combine the three leaching solutions o...

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Abstract

The invention discloses an environment-friendly and efficient levodopa production method. According to the production method, cat bean hulls are preprocessed, wax and oil on the hulls are removed, a solution circulation and substance exchange channel is formed, the cat beans are not crushed, thus the leaching of starch and protein in cat bean meat is greatly reduced, the generated process wastewater is reduced, energy is saved, and the environment is protected. Meanwhile, the leach liquor contains ethanol, so that the solubility of starch and protein in water can be reduced, and oxidation andblackening of levodopa can be effectively prevented by adding vitamin C. The yield of the levodopa product produced by the method is 3.0-3.5%, and the detected levodopa content is 99-101% and is higher than that of a levodopa product produced by an existing production process.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to an environment-friendly and efficient levodopa production method. Background technique [0002] Levodopa (3,4-Dihydrox ylphenylalanine, L-Dopa) is a phenylalanine compound and is currently the most commonly used treatment for essential tremor paralysis and non-pharmacological tremor syndrome (Parkinson's disease). effective medicine. Levodopa in the treatment of tremor paralysis, not only has a significant curative effect, but also has strong durability, overcoming the shortcomings of poor efficacy and large side effects of the past drugs for tremor paralysis. [0003] Mucuna cochinchinensis (Latin name: Mucuna cochinchinensis (Lour.) A. Cheval.), also known as Mucuna cochinchinensis, dragon claw bean, tiger claw bean, dog claw bean, cat cat bean, legume Mucuna cochinchinensis is an annual herbaceous vine . Its bean seeds are the raw materials for the production of levodopa m...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C229/36C07C227/28C07C227/40
CPCC07C227/28C07C227/40C07B2200/07C07C229/36
Inventor 李学坚银江林赵小超张雯艳袁经权陈奔陈柏承陆华
Owner GUANGXI UNIV OF CHINESE MEDICINE
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