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Method and device for preparing degradable microspheres for embolotherapy

A technology of microspheres and embolism, which is applied in the field of preparation of degradable microspheres for embolism therapy, which can solve the problems of wide distribution of microspheres, unsuitable embolic agent, and large size difference of microspheres, so as to achieve large particle size of microspheres and reduce mobile phase The amount, the effect of easy industrial production

Active Publication Date: 2020-06-19
山东采采医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Only the spray drying method and the high-speed homogeneous emulsification method can realize large-scale production, but the size of the produced microspheres varies greatly, from 0.2 to 200 μm, and the distribution of the microspheres is wide, which is not suitable for use as an embolism

Method used

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  • Method and device for preparing degradable microspheres for embolotherapy
  • Method and device for preparing degradable microspheres for embolotherapy
  • Method and device for preparing degradable microspheres for embolotherapy

Examples

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Embodiment 1

[0035] A device for preparing degradable microspheres for embolism therapy, comprising a stationary phase storage tank 1, a microsphere forming device 2 and a microsphere collection device 3; the stationary phase storage tank 1 is provided with a stationary phase outlet 1-1; The microsphere forming device 2 includes an inner tube 2-1 and an outer tube 2-2, the inner tube 2-1 is sleeved in the outer tube 2-2, and an annular space is formed between the inner tube 2-1 and the outer tube 2-2. Cavity 2-3, a micropore 2-4 is provided on the side wall of the inner tube 2-1, a stationary phase inlet 2-5 communicated with it is provided at one end of the inner tube 2-1, and an annular The microsphere outlet 2-6 connected with the cavity 2-3 and the mobile phase inlet 2-7; the stationary phase inlet 2-5 and the mobile phase inlet 2-7 are arranged at the same end of the microsphere forming device, and the stationary phase inlet 2-5 The microsphere outlet 2-6 is located at the two ends of...

Embodiment 2

[0039]A device for preparing degradable microspheres for embolism therapy, comprising a stationary phase storage tank 1, a microsphere forming device 2 and a microsphere collection device 3; the stationary phase storage tank 1 is provided with a stationary phase outlet 1-1; The microsphere forming device 2 includes an inner tube 2-1 and an outer tube 2-2, the inner tube 2-1 is sleeved in the outer tube 2-2, and an annular space is formed between the inner tube 2-1 and the outer tube 2-2. Cavity 2-3, a micropore 2-4 is provided on the side wall of the inner tube 2-1, a stationary phase inlet 2-5 communicated with it is provided at one end of the inner tube 2-1, and an annular The microsphere outlet 2-6 connected with the cavity 2-3 and the mobile phase inlet 2-7; the stationary phase inlet 2-5 and the mobile phase inlet 2-7 are arranged at the same end of the microsphere forming device, and the stationary phase inlet 2-5 The microsphere outlet 2-6 is located at the two ends of ...

Embodiment 3

[0053] A method for preparing degradable microspheres for embolism therapy, comprising the following steps:

[0054] (1) Weigh 100g polycaprolactone (PHA) (self-made, MW: 44201), dissolve it in dimethyl sulfoxide to make a stationary phase, and the mass fraction of PHA in the stationary phase is 30%;

[0055] (2) Micropore extrusion process is adopted, the diameter of the micropores on the inner tube is 100 μm, the mobile phase is ethanol solution (containing: 0.2% polyethylene glycol), and the stationary phase is extruded to the continuous circulation flow with 0.38MPa pressure In the mobile phase, on the interface in contact with the mobile phase, under the impact of the mobile phase, the extruded stationary phase breaks away from the micropores to form microspheres that are insoluble in the mobile phase. After the microspheres are solidified, collect the microspheres and vacuum The organic solvent was evaporated to dryness, and the surface of the microspheres was smooth and...

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Abstract

The invention belongs to the technical field of medicine preparation, and particularly relates to a method and a device for preparing degradable microspheres for embolotherapy. The method comprises the steps of dissolving PCL (polycaprolactone) or PHA (polyhydroxyalkanoate) in an organic solvent to form a stationary phase; and extruding the stationary phase into a mobile phase which flows continuously and circularly through micropores under pressure, enabling the extruded stationary phase to be separated from the micropores to form the microspheres insoluble in the mobile phase under the impulsive force effect of the mobile phase on an interface in contact with the mobile phase, collecting the microspheres, and recycling the mobile phase. Alcohol is adopted as the mobile phase, the hardening speed on the surfaces of the microspheres is increased, a water phase is not used, only a small amount of the mobile phase is used, sewage treatment is not needed, a corresponding device is supplemented, the mobile phase is recycled and finally recyclable, the amount of the mobile phase used for preparing equivalent microspheres is reduced, and the method is easy for industrial production.

Description

technical field [0001] The invention belongs to the technical field of medicine preparation, and in particular relates to a method and a device for preparing degradable microspheres for embolism therapy. Background technique [0002] Embolization is to inject an embolic agent to block the nutrient vessels supplying the lesion, so as to achieve the effect of starving the lesion cells or changing the flow direction of the blood vessels. It is a minimally invasive treatment using modern high-tech means. Under the guidance of medical imaging equipment, special catheters, guide wires and other precision instruments are introduced into the human body to diagnose and locally treat pathological conditions in the body. The main applications of embolization include hemostasis, treatment of vascular diseases, treatment of hyperemic tumors, organ inactivation, and blood flow diversion. [0003] In recent years, domestic embolic materials are mainly divided into two categories: one is d...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/00A61L24/04B01J13/02
CPCA61L24/001A61L24/043A61L24/00B01J13/02C08L67/04
Inventor 苏红清李建王栋
Owner 山东采采医疗科技有限公司
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