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Application of adinandra nitida and camellianin A in preparation of medicine for treating gastric ulcer

A technology for camellia glycosides and gastric ulcers, applied in the application field of Shibi tea and its active monomers, can solve the problems that there is no relevant research on the therapeutic effect, achieve good therapeutic effect, reduce inflammation, and reduce the degree of injury

Active Publication Date: 2020-06-19
SOUTH CHINA UNIV OF TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no relevant research on the therapeutic effect of Shibi tea and its main flavonoid kalenoside A on gastric ulcer

Method used

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  • Application of adinandra nitida and camellianin A in preparation of medicine for treating gastric ulcer
  • Application of adinandra nitida and camellianin A in preparation of medicine for treating gastric ulcer
  • Application of adinandra nitida and camellianin A in preparation of medicine for treating gastric ulcer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Preparation of Shibi tea freeze-dried powder and camelliaside A

[0035] The dry leaves of Shibi tea are crushed with a pulverizer, and the tea powder is extracted in boiling water (the mass-volume ratio of tea / water is 1:20) 3 times, each for 30 minutes. The obtained extracts are filtered and combined, and the extracts are concentrated by rotary evaporation at 60° C., and then freeze-dried into freeze-dried Shibi tea powder for later use.

Embodiment 2

[0037] The preparation method of camellianin A, the inventors disclosed in previous studies: Yuan, E.; Liu, B.; Ning, ZJ Jofp; preservation, Preparation and antioxidant activity of camellianin A from Adinandranitida leaves. 2008, 32(5), 785-797. The method is as follows: Extract 100 g of Shibi tea leaves with 1500 mL of boiling water for 60 minutes. The filtered residue was extracted with 1200 mL boiling water for 60 minutes and filtered. The two filtrates were mixed, stored at 2°C for 24h, and then filtered to collect the precipitate. The precipitate was dried at 60°C for 5 hours to obtain a crude product. The crude product was recrystallized with 20% ethanol for 5 times and purified to obtain crystals. The crystals were dried at 60°C for 3 hours to obtain a light yellow camellin A monomer with a purity of over 98%.

Embodiment 3

[0039] 1. Construct an animal model of acute gastritis

[0040] Purchasing healthy 7-week-old male ICR mice and rearing them adaptively for 1 week. Randomly group them into: (1) normal control group; (2) model control group; (3) positive drug control group; (4) low-dose camelliaside Group A; (5) High-dose Camellia glycoside A group; (6) Low-dose Shibi tea group; (7) High-dose Shibi tea group, each with 7 animals.

[0041] Except for the normal control group, animals in each group were fasted overnight and then used 60% ethanol + 0.4M hydrochloric acid for acute gastric ulcer modeling. The gastric dose was 10 mL / kg body weight. The animals in the normal control group were fasted overnight and then the same dose Pure water was used as a blank control. After the model was successfully established, the administration was administered for 2 consecutive days the next day.

[0042] Cimetidine, camelliaside A and Shibi tea freeze-dried powder were all dissolved in 0.5% CMCNa solution, and ...

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Abstract

The invention belongs to the technical field of applications of adinandra nitida and an active monomer of the adinandra nitida, and specifically relates to an application of the adinandra nitida and active monomer camellianin A (CA) in preparation of a medicine for treating gastric ulcer. The invention mainly protects the application of the adinandra nitida and the camellianin A in preparation ofthe medicine for treating the gastric ulcer, and the application of the adinandra nitida or the camellianin A in preparation of the medicine for treating the gastric ulcer, wherein the camellianin A is extracted from the adinandra nitida. Animal acute gastric ulcer model experiments prove that the adinandra nitida water extract and the active monomer camellianin A both have a good therapeutic effect on the gastric ulcer, down-regulate the expression of relevant inflammatory factor IL-6 by regulating a NFkappaB inflammation regulation signaling pathway, and reduces the damage degree and inflammatory reaction of the gastric ulcer.

Description

Technical field [0001] The invention belongs to the technical field of application of Shibi tea and its active monomers, and specifically relates to the use of Shibi tea and its active monomer camellin A in preparing medicines for treating gastric ulcer. Background technique [0002] Gastric ulcer refers to gastric mucosal damage caused by acid digestive damage. It often occurs in the corners of the stomach, gastric antrum and cardia. It is a type of peptic ulcer and is a common and frequent gastrointestinal disease. Patients with gastric ulcer usually have upper abdominal pain, such as a burning sensation, as well as typical dyspeptic symptoms, such as bloating, nausea, fullness, and heartburn, and even peptic ulcer complications such as bleeding, perforation or gastric outlet obstruction. Severe symptoms greatly affect the patient's quality of life and work quality. [0003] At present, there are a variety of clinical treatment drugs for gastric ulcers, including histamine recep...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/82A61K31/7048A61P1/04
CPCA61K31/7048A61K36/82A61K2236/331A61K2236/39A61K2236/53A61P1/04A61K2300/00
Inventor 袁尔东练颖仪张文姬孙世利黎秋华孙伶俐赖幸菲陈若虹
Owner SOUTH CHINA UNIV OF TECH
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