Pharmaceutical application of asiaticoside or analogues thereof

A technology of asiaticoside and madecassoside, which is applied in the field of medicine, can solve problems such as diabetic foot, amputation, and reduced wound healing ability, so as to shorten wound healing time, reduce pancreatic inflammation, and increase high-density lipids. The effect of protein

Pending Publication Date: 2020-06-19
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The reduced wound healing ability of diabetic patients is also a typical complication of diabetes. If chronic damage or ulceration occurs in the foot, it may lead to diabetic foot, and severe cases may lead to amputation. So far, there is no effective treatment method
There is no report that asiaticoside has therapeutic activity in diabetes

Method used

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  • Pharmaceutical application of asiaticoside or analogues thereof
  • Pharmaceutical application of asiaticoside or analogues thereof
  • Pharmaceutical application of asiaticoside or analogues thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Example 1: The curative effect evaluation experiment of asiaticoside of the present invention in treating NOD mouse type 1 diabetes model

[0040] 1. Establishment of type 1 diabetes model mice:

Embodiment 1-1

[0041] Example 1-1. NOD mouse type 1 diabetes model.

[0042] Female NOD mice, 10-11 weeks old, were purchased from Beijing Huafukang Biotechnology Co., Ltd. After one week of adaptive feeding in the SPF grade animal room, the animals were divided into groups according to random blood sugar.

[0043] 2. Treatment experiments on diabetic mice

Embodiment 2-1

[0044] Example 2-1. Twenty female NOD mice aged 10-11 weeks were randomly divided into 2 groups, 10 in each group: solvent control group and asiaticoside group. The solvent control group was given 0.5% CMC-Na; the asiaticoside group was given 60 mg / kg. According to administration once a day, continuous administration for 6 weeks, random blood glucose monitoring 2 times a week, a total of 12 times.

[0045] 3. The curative effect evaluation experiment of asiaticoside of the present invention in treating NOD mice type 1 diabetes model mice

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PUM

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Abstract

The invention provides application of asiaticoside or analogues thereof to preparation of a medicament for treating diabetes and related complications. According to the invention, the asiaticoside orthe analogues thereof can reduce blood glucose of a type-1 diabetic mouse, reduce pancreas inflammations, protect an insulin secretion function of pancreatic beta cells, increase insulin and have a treatment effect on the type-1 diabetes. The asiaticoside or the analogues thereof can reduce blood glucose of a db / db type-2 diabetic mouse, increase insulin, increase high-density lipoproteins, reducetriglyceride and also have a treatment effect on type-2 diabetes. According to the invention, the asiaticoside or the analogues thereof can also reduce urine microalbumin, increase urine creatinine,reduce serum creatinine and blood urea nitrogen, and also have a treatment effect on diabetes and nephrosis. The asiaticoside or the analogues thereof can also shorten wound healing time of diabetic foot model mice and also have a treatment effect on the diabetic foot.

Description

technical field [0001] The invention relates to a medicine for treating diabetes and its application, belonging to the technical field of medicine. Background technique [0002] Diabetes mellitus (DM) is a metabolic disease characterized by relative or absolute insulin deficiency. Absolute insulin deficiency is type 1 diabetes, and relative insulin deficiency is type 2 diabetes. Type 1 diabetes, also known as insulin-dependent diabetes mellitus (Type 1diabetes mellitus, T1DM), is an autoimmune disease that specifically damages the pancreas mediated by Th1 cells. It is the insulin-secreting cells in the patient's body, the pancreatic islet β-cells, which are attacked by the autoimmune system, are destroyed, and their function is lost, resulting in diabetes caused by an absolute lack of insulin. Since β cells have the function of producing insulin and regulating blood sugar, the destruction of β cell population eventually leads to the disorder of blood sugar and the occurrenc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7024A61K31/56A61P3/10A61P5/50A61P13/12A61P1/16A61P17/02A61P25/00A61P27/02A61P9/12A61P9/10A61P9/00
CPCA61K31/7024A61K31/56A61P3/10A61P5/50A61P13/12A61P1/16A61P17/02A61P25/00A61P27/02A61P9/12A61P9/10A61P9/00
Inventor 吴亮牟畅崔雪婷葛峰张莹莹蔡溪云弋方睿宁董浩蔡磊郝园园吴舒婷冯陈杰陈佳敏刘宙吴晓明
Owner CHINA PHARM UNIV
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