Photoacoustic Doppler blood flow velocity and blood oxygen content measuring system and measuring method

A technology of blood oxygen content and measurement system, which is applied in the field of flow velocity measurement, can solve the problems that the blood flow velocity cannot be measured accurately, and achieves the effects of high detection bandwidth, wide range of measurable flow velocity, and large measurable depth

Pending Publication Date: 2020-06-19
SHENZHEN UNIV
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  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

If the difference between the photoacoustic signal and the noise is not large or the photoacoustic signal is smaller than the noise, the advantages of digital signal processing and phase-locking technology cannot be fully utilized to accurately extract the required signal, so it is difficult to accurately measure the blood flow rate and can not do more Photoacoustic Doppler velocity measurement at multiple wavelengths

Method used

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  • Photoacoustic Doppler blood flow velocity and blood oxygen content measuring system and measuring method
  • Photoacoustic Doppler blood flow velocity and blood oxygen content measuring system and measuring method
  • Photoacoustic Doppler blood flow velocity and blood oxygen content measuring system and measuring method

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Embodiment 1

[0046] like figure 1 As shown, the present invention discloses a photoacoustic Doppler blood flow velocity and blood oxygen content measurement system, including:

[0047] A pulse light filtering and collimating unit for filtering and collimating to obtain collimated laser light;

[0048] The pulsed laser amplitude modulation unit of the Glan prism and 1 / 4 wave plate used to modulate the amplitude of the collimated laser with the polarization directions perpendicular to each other;

[0049] A sample unit for placing a blood vessel sample;

[0050] A collection and amplification unit for collecting and amplifying the pulsed laser acoustic wave signal generated by irradiating through the sample unit;

[0051] A signal demodulation unit for demodulating the amplified photoacoustic signal and the reference signal;

[0052] Spectrum analysis unit for processing Doppler analysis on the signals obtained by the collection amplification unit and signal demodulation unit to obtain th...

Embodiment 2

[0054] like figure 2 As shown, the present invention discloses a photoacoustic Doppler blood flow velocity and blood oxygen content measurement system, wherein each component unit is introduced as follows:

[0055] The pulse light filtering and collimating unit includes a supercontinuum laser 1, a filter 2 and a coupling collimating lens 4. The pulsed laser light generated by the supercontinuum laser 1 is transmitted to the coupling collimating lens 4 through the filter 2 and single-mode fiber 3 in sequence. After coupling and collimation, a collimated laser is obtained. The filter 2 screens the pulse laser generated by the supercontinuum laser 1 to form a 532nm, 20MHz repetition frequency pulse laser.

[0056] The pulsed laser amplitude modulation unit includes a horizontal polarizing Glan prism 5, a 1 / 4 wave plate 6 whose polarization direction is 45 degrees to the direction of the horizontal polarizing Glan prism 5, an electro-optic crystal 7 and a vertical polarizing Gla...

Embodiment 3

[0063] Another object of the present invention is to protect the measurement method using the above photoacoustic Doppler blood flow velocity and blood oxygen content measurement system.

[0064] In the present invention, the supercontinuum laser is applied to the photoacoustic Doppler blood flow velocity measurement, and the sine wave intensity modulation is performed on the pulsed laser at a frequency of 1 MHz. At present, the modulated laser is used to directly irradiate the flow in the transparent hose. The photoacoustic signal generated by the particles is relatively strong, and then the ultrasonic transducer, preamplifier, and lock-in amplifier are used to collect, amplify, demodulate, and process the signal to form a set of flow velocity measurement with high accuracy, a wide range of measurable flow velocity, and a measurable A photoacoustic Doppler blood flow velocity measurement system with large depth, small spectral broadening, high spectral resolution, wide wavelen...

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Abstract

The invention discloses a photoacoustic Doppler blood flow velocity and blood oxygen content measuring system. The system comprises a pulsed light filtering and collimating unit, a pulsed laser amplitude modulation unit, a sample unit, a collecting and amplifying unit, a signal demodulation unit and a spectrum analysis unit. The invention further discloses a measuring method adopting the measuringsystem. The photoacoustic Doppler blood flow velocity and blood oxygen content measuring system and the measuring method have the advantages of being high in measuring precision, large in measurableflow velocity range, large in measurable depth, small in spectrum broadening, high in spectrum resolution, large in wavelength selection range, high in detection bandwidth and high in system sensitivity.

Description

technical field [0001] The invention relates to the technical field of flow velocity measurement, in particular to a photoacoustic Doppler blood flow velocity and blood oxygen content measurement system and a measurement method thereof. Background technique [0002] The photoacoustic Doppler effect means that when the light-absorbing material sample moving relative to the ultrasonic transducer absorbs light, the acoustic wave detected by the ultrasonic transducer under light is due to the photoacoustic effect and the Doppler effect. Le frequency shift phenomenon. Obtain the mean Doppler shift by measuring f d , the average velocity can be obtained by calculating Where θ is the angle between the direction of blood flow and the axis of the ultrasonic transducer, c a is the propagation speed of the sound wave, f 0 is the intensity modulation frequency of the continuous light wave. [0003] The existing photoacoustic blood flow velocity measurement technology mainly includ...

Claims

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Application Information

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IPC IPC(8): A61B5/026A61B5/1455A61B5/00G01D21/02
CPCA61B5/0095A61B5/0261A61B5/7257A61B5/14551A61B5/14542G01D21/02
Inventor 刘燕彬蔡建芃方晖袁小聪
Owner SHENZHEN UNIV
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