Application of zanthoxylum nitidum extract in preparation of medicine for preventing and treating spinal fusion surgery inflammation
A technology of double-sided needles and extracts, applied in the direction of drug combinations, antipyretics, anti-inflammatory agents, etc., can solve the problem of uncontrollable exudation of inflammatory substances, and achieve the effect of reducing high expression and high permeability
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[0030] This example involves the specific implementation process and efficacy verification of the prevention and treatment of BMP-2-induced inflammation around spinal fusion surgery with LMZ extract:
[0031] 1. Cell culture
[0032] Human umbilical vein endothelial cells (HUVECs) were purchased from the American Type Culture Collection. In high glucose endothelial cell culture medium (Dulbecco's Modified Eagle Medium, Sigma, 211-500) containing 10% fetal bovine serum, 1% penicillin and 1% streptomycin, 37°C, 5% CO 2 cultured in a wet cell incubator. When the whole cell fusion rate reaches about 80%, the drug treatment is carried out.
[0033] 2. Drug handling
[0034] Modeling: RhBMP-2 with a concentration gradient of 0, 10 and 20ng / ml acted on human umbilical vein endothelial cells for 8 hours.
[0035] Intervention with LMZ extract + modeling: 4 hours before 20ng / ml rhBMP-2 intervention, 3 doses of LMZ extract (extractable or commercially available, this example The ex...
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