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Nano mesoporous bioactive glass and preparation method thereof

A bioactive glass and nano-mesoporous technology, applied in the field of biomedical materials, can solve the problems of single material performance, lack of antibacterial properties, and difficult product particle size, and achieve excellent antibacterial performance, good durability, and high stability.

Active Publication Date: 2020-06-02
北京纯粹主义科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the existing problems of this method include that the particle size of the product is difficult to meet the needs of various biological applications, and the material performance is relatively simple, such as the lack of antibacterial properties required for human body application.

Method used

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  • Nano mesoporous bioactive glass and preparation method thereof
  • Nano mesoporous bioactive glass and preparation method thereof
  • Nano mesoporous bioactive glass and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] A kind of nano mesoporous bioactive glass, its preparation method is as follows:

[0050] (1) 500.05g water, 511.07g ethanol, 8.15g dioctadecyl dimethyl ammonium chloride and 4.14g triethanolamine are successively added into a beaker to form a mixed solution, and the pH value of the mixed solution is 10;

[0051] Then 34.72g tetraethyl orthosilicate, 5.06g triethyl phosphate, 18.41g calcium nitrate tetrahydrate and 0.44g nano-zinc oxide were added to the above mixed solution in sequence, and after stirring evenly, the precursor of nano-mesoporous bioactive glass was obtained. Biosol;

[0052] (2) Take out the precursor sol obtained in step (1) and seal it well, put it in an oven at 60°C for aging for 1 day; then place it in an oven at 120°C for 3 days to obtain dried nano-mesoporous organisms Active glass precursor powder;

[0053] (3) Place the obtained precursor powder in a high-temperature furnace and heat-treat at a temperature of 600° C. for 5 hours to obtain the...

Embodiment 2

[0055] A kind of nano mesoporous bioactive glass, its preparation method is as follows:

[0056] (1) 500.06g water, 511.03g ethanol, 3.26g dioctadecyl dimethyl ammonium chloride and 2.07g triethanolamine are successively added into a beaker to form a mixed solution, and the pH value of the mixed solution is 10;

[0057] Then 3.34g of white carbon black, 0.63g of triethyl phosphate, 2.66g of calcium chloride and 0.21g of nano-zinc oxide were added to the above-mentioned mixed solution, and after stirring evenly, the precursor sol of nano-mesoporous bioactive glass was obtained;

[0058] (2) Take out the precursor sol obtained in step (1) and seal it well, put it in an oven at 70°C for aging for 1 day; then place it in an oven at 90°C to dry for 3 days, and obtain the dried nano-mesoporous organism Active glass precursor powder;

[0059] (3) Place the obtained precursor powder in a high-temperature furnace and heat-treat at a temperature of 700° C. for 3 hours to obtain the nan...

Embodiment 3

[0061] A kind of nano mesoporous bioactive glass, its preparation method is as follows:

[0062] (1) 500.09g water, 511.02g ethanol, 6.51g dioctadecyl dimethyl ammonium chloride and 3.32g triethanolamine are successively added into a beaker to form a mixed solution, and the pH value of the mixed solution is 10;

[0063] Then 31.58g of sodium silicate, 1.42g of triethyl phosphate, 16.74g of calcium nitrate tetrahydrate and 0.16g of nano-zinc oxide were added to the above mixed solution in sequence, and after stirring evenly, the precursor sol of nano-mesoporous bioactive glass was obtained. ;

[0064] (2) Take out the precursor sol obtained in step (1) and seal it well, put it in an oven at 80°C and age it for 1 day; then place it in an oven at 100°C and dry it for 3 days to obtain the dried nano-mesoporous organism Active glass precursor powder;

[0065] (3) The obtained precursor powder is placed in a high-temperature furnace, and heat-treated at a temperature of 800° C. fo...

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Abstract

The embodiment of the invention discloses nano mesoporous bioactive glass. The nano mesoporous bioactive glass comprises SiO2, CaO, P2O5 and nano ZnO. The bioactive glass is improved in the aspects ofparticle size characteristics and functional expansion, has the characteristics of a nano mesoporous material and nano ZnO, is a human body biocompatible material with excellent biological activity and sterilization effect, can be used as a material for oral treatment and dental restoration, and can also be used as a material for bone restoration and wound healing. The embodiment of the inventionalso provides a preparation method of the nano mesoporous bioactive glass.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a nano-mesoporous bioactive glass and a preparation method thereof. Background technique [0002] Bioactive glass (BioActiveGlass, BAG) is a very important class of biomaterials, this material is made of SiO 2 、Na 2 O, CaO and P 2 o 5 Silicate glass composed of basic components such as , has good biocompatibility and bioactivity, and can be mineralized in human body fluids to form hydroxyapatite, an important component of human bone. When it is implanted into the human body as a bone repair material and scaffold material, this material can bond bone tissue, promote cell reproduction, enhance gene expression of osteoblasts and growth of bone tissue. The earliest biological glass material was discovered by Professor L. Hench of the University of Florida in 1969. This material is called 45S5 glass (mass fraction is 24.5% Na 2 O-24.5%CaO-45%SiO 2 -6%P 2 o 5 ), ob...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C03C4/00C03C3/097
CPCC03C4/0007C03C3/097C03C4/0021C03C2204/02
Inventor 王胜地于健飞
Owner 北京纯粹主义科技有限公司
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