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Medical composition for preventing and treating alzheimer's disease

A technology for senile dementia and a composition, which is applied in the field of drugs for the treatment of neurodegenerative diseases of the central nervous system, can solve the problems of no relevant prompts, no research results, no research on synergistic effects, etc., so as to improve cognitive impairment. , The effect of prevention and treatment of senile dementia is obvious and the quality is easy to control

Inactive Publication Date: 2020-06-02
GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Another scholar, Yang Sude, determined that three glycosides, echinacoside, verbascoside and isobrucoside, contained in Cistanche total glycosides capsules (Yang Sude et al. HPLC method for the simultaneous determination of echinacoside and verbascoside in Cistanche total glycosides capsules , the content of different verbascoside[J].World Science and Technology—Modernization of Traditional Chinese Medicine ★Research on Traditional Chinese Medicine, 2015, Vol. The main glycoside components in Glycoside Capsules have been determined. As for which glycoside components are contained in it and which glycoside components play a role in the prevention and treatment of senile dementia, no research results have been given, especially which glycoside components have synergistic curative effects. Conduct research and give no hints

Method used

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  • Medical composition for preventing and treating alzheimer's disease
  • Medical composition for preventing and treating alzheimer's disease
  • Medical composition for preventing and treating alzheimer's disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0172] (1) Prescription: 6g of verbascoside, 4g of isoverbacoside.

[0173] (2) Preparation method:

[0174] Combine verbascoside and isobracoside, add 25g of PVP, 20g of CMC-Na, 8g of L-HPC, 6g of CMS-Na and an appropriate amount of 65% ethanol to prepare a soft material, pass through a sieve, dry at 60°C to obtain granules, and sieve for granulation Finally, it is packaged into granules by packaging equipment.

Embodiment 2

[0176] (1) Prescription: 5g of verbascoside, 5g of isoverbacoside.

[0177] (2) Preparation method:

[0178] Combine verbascoside and isoverbacoside, add 50g of honey, 40g of rice paste, 40g of batter and an appropriate amount of 65% ethanol to prepare a soft material, and then make a pill.

Embodiment 3

[0180] (1) Prescription: 7g of verbascoside and 3g of isoverbacoside.

[0181] (2) Preparation method:

[0182] Combine verbascoside and isobracoside, add 30g of starch, 10g of dextrin, 8g of sucrose and an appropriate amount of 65% ethanol, mix evenly, granulate, dry to obtain granules, sieve and granulate, add 0.5g of micropowder silica gel, mix evenly, and press into regular tablets.

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PUM

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Abstract

The invention relates to a medical composition for preventing and treating alzheimer's disease. The medical composition consists of effective components and medically acceptable auxiliary materials. The medical composition is characterized in that the effective components consist of the following components in percentage by weight of 50%-80% of verbascoside and 20%-50% of isoacteoside. The medicalcomposition can obviously improve cognitive disorder of rapid aging(SAMP8) mice, and can reduce accumulation of A beta in hippocampi of SAMP8 mice, inflammatory reaction and oxidative stress, so as to alleviate damage of nerve cells and is notable in effect of preventing and treating alzheimer's disease.

Description

[0001] Field of invention: [0002] The invention relates to a pharmaceutical composition, in particular to a medical preparation containing organic active ingredients, and the medical preparation is a medicine for treating neurodegenerative diseases of the central nervous system. [0003] technical background: [0004] Alzheimer's disease is a chronic, primary brain, degenerative disease of the central nervous system characterized by progressive cognitive impairment and behavioral impairment. Time and space orientation impairment, etc., eventually lead to death, mostly in the elderly. So far, about 47 million people in the world suffer from Alzheimer's disease, and this number may increase to 131 million by 2050. The disease also has a huge economic impact. It has become one of the major challenges to public health in the world. my country is a country with a large population. With the acceleration of the aging process of the population, the harm of this disease has attracte...

Claims

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Application Information

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IPC IPC(8): A61K31/7034A61P25/28
CPCA61K31/7034A61P25/28
Inventor 林朝展祝晨蔯
Owner GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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