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Glutathione-protected strong-fluorescence-emission gold-platinum alloy nano-cluster and controllable preparation method thereof

A glutathione, fluorescence emission technology, applied in nanotechnology, nano-optics, nanotechnology and other directions, can solve the problem of limited reports of near-infrared fluorescence emission nanoclusters

Active Publication Date: 2020-05-29
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] Although considerable progress has been made in the study of nanoclusters in recent years, reports on near-infrared fluorescence-emitting nanoclusters (NIR-NCs) are still limited.

Method used

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  • Glutathione-protected strong-fluorescence-emission gold-platinum alloy nano-cluster and controllable preparation method thereof
  • Glutathione-protected strong-fluorescence-emission gold-platinum alloy nano-cluster and controllable preparation method thereof
  • Glutathione-protected strong-fluorescence-emission gold-platinum alloy nano-cluster and controllable preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0025] In this example, the effect of different reaction times on the fluorescence intensity of the nanoclusters is mainly explored. Add 800 microliters and 100 microliters of chloroauric acid trihydrate aqueous solution and chloroplatinic acid hexahydrate aqueous solution with a concentration of 10 mmol / ml into the polytetrafluoroethylene lining of the stainless steel reaction kettle, stir well, and then add a concentration of 100 microliters. 360 microliters of glutathione aqueous solution in millimolar / milliliter, and then add 400 microliters, 500 millimoles / ml of sodium citrate (CA) aqueous solution. Finally, deionized water was added to make the volume of the solution 10 ml. After stirring evenly, the polytetrafluoroethylene lining was transferred to a stainless steel reaction kettle, which was placed in an oven whose temperature was set at 110°C for hydrothermal reaction. Then take out the reaction kettle after 30, 60, 90, 120, 150, 180, 210 and 240 minutes respectively,...

Embodiment 2

[0028] In this example, the effect of different reaction temperatures on the fluorescence intensity of the nanoclusters was mainly explored. Add 800 microliters and 100 microliters of chloroauric acid trihydrate aqueous solution and chloroplatinic acid hexahydrate aqueous solution with a concentration of 10 mmol / ml into the polytetrafluoroethylene liner, stir well, and then add a concentration of 100 millimolar 360 microliters of glutathione aqueous solution per milliliter, and then add 400 microliters, 500 mmol / ml of sodium citrate (CA) aqueous solution. Finally, deionized water was added to make the volume of the solution 10 ml. After stirring evenly, the polytetrafluoroethylene lining was transferred to a stainless steel reaction kettle. The stainless steel reaction kettle was placed in an oven. Thermal reaction, the reaction time is 150 minutes. After the reaction, the reactor was taken out and cooled to room temperature to obtain Au-PtNCs@GSH prepared under different rea...

Embodiment 3

[0031] In this example, the effect of different molar ratios of chloroauric acid to chloroplatinic acid on the fluorescence intensity of the nanoclusters is mainly explored. In the polytetrafluoroethylene liner, adding concentration is 800 microliters of chloroauric acid trihydrate aqueous solution of 10 mmol / ml, and then respectively adding 50, 100, 200, 100, 200, After stirring 300 and 400 microliters evenly, add 100 mmol / ml glutathione (GSH) aqueous solution 340, 360, 400, 440 and 480 microliters respectively, and then add 400 microliters, 500 mmol / ml Sodium citrate (CA) aqueous solution. Finally, deionized water was added to make the volume of the solution 10 ml. After stirring evenly, the polytetrafluoroethylene lining was transferred to a stainless steel reaction kettle. The stainless steel reaction kettle was placed in an oven, and the temperature of the oven was set at 110°C for hydrothermal reaction for 150 minutes. After the reaction, it was cooled to room temperatu...

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Abstract

The invention discloses a glutathione-protected strong-fluorescence-emission gold-platinum alloy nano-cluster and a controllable preparation method thereof, and belongs to the technical field of preparation of strong near-infrared light-emitting metal nano-cluster materials. A chloroauric acid trihydrate aqueous solution and a chloroplatinic acid hexahydrate aqueous solution are used as a gold source and a platinum source, sodium citrate is used as a reducing agent, and glutathione is used as a stabilizer and a ligand. The preparation method comprises the steps: uniformly mixing the chloroauric acid trihydrate aqueous solution and the chloroplatinic acid hexahydrate aqueous solution, adding a glutathione solution into the mixed solution, uniformly mixing, and adding a sodium citrate solution; and transferring the mixed solution into a reaction kettle, and carrying out hydrothermal reaction at the temperature of 100-120 DEG C for 30-210 min, and thus obtaining a glutathione-protected strong-fluorescence-emission gold-platinum alloy nano-cluster solution. Controllable preparation of the gold-platinum alloy nano-cluster with quite high stability for two different fluorescence emissions is realized by finely regulating and controlling experimental conditions such as reaction time, reaction temperature and a feeding ratio of reaction raw materials.

Description

technical field [0001] The invention belongs to the technical field of preparation of strong near-infrared luminescent (NIR) metal nano-cluster materials, in particular to a gold-platinum alloy nano-cluster with strong fluorescence emission protected by glutathione with red light or near-infrared fluorescence emission characteristics and its potential Control the preparation method. Background technique [0002] Metallic nanoclusters (NCs) have attracted great attention in the fields of fluorescence sensing, imaging, and labeling due to their outstanding optical properties. Most importantly, the emission wavelength of metal nanoclusters (NCs) can be changed from visible light fluorescence emission to near-infrared (NIR ) fluorescence emission, the red shift of the fluorescence emission wavelength will be beneficial to promote the application of nanoclusters in fluorescence imaging and other aspects. In the existing research results, gold nanoclusters whose size and fluores...

Claims

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Application Information

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IPC IPC(8): C09K11/02C09K11/87B82Y20/00B82Y40/00
CPCB82Y20/00B82Y40/00C09K11/025C09K11/87
Inventor 吴玉清李洪伟高延才
Owner JILIN UNIV
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