Pyrolytic diterpene alkaloid compound, and preparation method and application thereof

Abstract

The invention provides a pyrolytic diterpenoid alkaloid compound as shown in a formula I which is described in the specification, or a salt, a stereoisomer or a solvate thereof, and a preparation method of the pyrolytic diterpenoid alkaloid compound. The invention also provides application of the compound or the salt, the stereoisomer or the solvate thereof in preparation of medicines used for preventing and / or treating ventricular premature beat, ventricular tachycardia and antiarrhythmia, and excellent clinical prospects are obtained.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a pyrolysis type diterpene alkaloid compound and its preparation method and application. Background technique [0002] Arrhythmia is a clinically common and very dangerous cardiovascular disease. For a long time, people have been devoting themselves to the research of antiarrhythmic drugs, but there has been no obvious breakthrough in the past 20 years. [0003] Clinical treatment of arrhythmias can use antiarrhythmic drugs, or choose radiofrequency ablation and implantable automatic cardioverter defibrillator (ICD). [0004] Antiarrhythmic drugs still play an important role in the treatment of arrhythmias for the following reasons: (1) Most tachyarrhythmias require drugs to terminate the attack during acute attacks; (2) Some supraventricular premature beats and premature ventricular beats that cause symptoms need to be controlled with drugs and prevention of recurrence; ③Pa...

AI Technical Summary

Problems solved by technology

However, the processing principle of the sand-frying method has not been fully elucidated. How does the structure of the toxic alkaloid transform during the sand-frying process, and is the toxicity of the transformed product lower than that of the original alkaloid? And because the processing principle of the sand-frying method has not been clarified, the quality evaluation of the sand-stir-fried products is still judged by subjective experience such as: the medicinal materials are fried until "the skin is browned and the cross-section is yellow", and there is a lack of quantitative quality control indicators.

In addition, studies have shown that although some diterpene alkaloids have similar structures, they have opposite effects. For example, some can cause arrhythmia and have cardiotoxicity, while others have the effect of treating arrhythmia.

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