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Quality control method of cough-relieving loquat syrup

A quality control method and technology for relieving cough loquat syrup, applied in the field of quality control of cough relieving loquat syrup, can solve problems such as difficulty in comprehensively reflecting medicinal taste, single quality control, few indicators, etc., and achieve high accuracy, good reproducibility, and simple operation. Effect

Active Publication Date: 2020-05-19
江西杏林白马药业股份有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The present invention overcomes the defects of the prior art that basically only detects one or two components of a single Chinese herbal medicine in the content control of cough loquat syrup, single quality control, few indicators, and it is difficult to fully reflect the quality status of many medicinal flavors and many components. Based on this, combined with actual production efficiency, a quality control method for cough loquat syrup is provided

Method used

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Embodiment 1

[0022] 1 Instruments and reagents

[0023] 1.1 Instrument

[0024] Agilent1290 liquid chromatograph (with photodiode array DAD detector), quaternary pump, autosampler, column thermostat, workstation); analytical balance (Germany Sartoriu company); Milli-Q ultrapure water (USA Millipore company) ; Vortex shaker (Germany IKA company), centrifuge (USA Beckman company).

[0025] 1.2 Reagent

[0026] Acetonitrile (chromatographically pure, German Merck Company), potassium dihydrogen phosphate (analytical pure, Sinopharm Chemical Reagent Co., Ltd.), glacial acetic acid (excellent grade, Sinopharm Chemical Reagent Co., Ltd.). Amygdalin (purity ≥ 99.0%, Chinese Academy of Sciences), Morusin B, and crotonine reference substance (purity ≥ 99.0%, Dr. Ehrensorfer, Germany). Cough-relieving loquat syrup is a commercially available product of Jiangxi Xinglin Baima Pharmaceutical Manufacturing Enterprise, 5 batches, 2 bottles per batch, 200mL / bottle.

[0027] 2 Methods and results

[00...

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Abstract

The invention discloses a quality control method of cough-relieving loquat syrup. According to the method, an HPLC method is established to determine the content of amygdalin, cortex mori radicis B and neostemonine. The method overcomes the defects that in the prior art, only one or two components of one traditional Chinese medicinal material are basically detected in the aspect of the content control of the cough-relieving loquat syrup, the quality control is single, indexes are few, and the quality conditions of multiple medicines and multiple components are difficult to comprehensively reflect, and the actual production efficiency is combined. The quality control method is reasonable in design, accurate, reliable, high in specificity and easy to operate, the medicine quality in the links of production, circulation, use and the like of a product can be effectively controlled, it is guaranteed that the production process is controllable, the clinical use safety is guaranteed, and reliable guarantee is provided for stable and exact curative effect of the product.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, and in particular relates to a quality control method for antitussive loquat syrup. Background technique [0002] Cough-relieving loquat syrup is a commonly used medicine for relieving cough and reducing phlegm. It has the effects of clearing the lung, relieving cough and reducing phlegm. It is used for the treatment of cough with phlegm and bronchitis. , Platycodon grandiflorum 78g, Baibu 94g, peppermint oil 3mL. At present, there are many domestic manufacturers of cough loquat syrup, with a total of 34 manufacturers and 34 approval numbers. [0003] The current quality standard for cough-relieving loquat syrup is "Ministry of Health Drug Standards", Volume Nine of Traditional Chinese Medicine Prescriptions) (WS3-B-1702-94). In view of the fact that the current standard is relatively old and lacks the determination of the content of the main components, some patents and documents h...

Claims

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Application Information

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IPC IPC(8): G01N30/02G01N30/06
CPCG01N30/02G01N30/06G01N2030/065
Inventor 胡志文
Owner 江西杏林白马药业股份有限公司
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