Long-acting antibacterial mildew inhibitor, preparation method thereof, and application of long-acting antibacterial mildew inhibitor in space station environment

An antibacterial and antifungal agent, long-acting technology, applied in the field of antibacterial and antifungal agents, can solve problems such as lack of versatility, hidden dangers to the health of astronauts, easy discoloration, etc., to achieve drug resistance, no hidden danger of discoloration, and no toxic components Effect

Active Publication Date: 2020-05-08
SHENZHOUSPACEBIOTECHGRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, silver ions have a limited antibacterial time and are easy to change color after being used on textiles. They are not universal in the antibacterial application of various materials in the space station.
And more importantly, the accumulation toxicity of silver nano-ions in the human body has received more and more attention. Therefore, the large-scale use of silver-ion antibacterial products in the space station may cause hidden dangers to the health of astronauts.
[0004] To sum up, the excessive reproduction of microorganisms in space is a safety hazard that threatens the health of astronauts and the normal operation of components in the cabin. The existing methods cannot achieve the purpose of long-term and effective control of microbial reproduction.

Method used

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  • Long-acting antibacterial mildew inhibitor, preparation method thereof, and application of long-acting antibacterial mildew inhibitor in space station environment
  • Long-acting antibacterial mildew inhibitor, preparation method thereof, and application of long-acting antibacterial mildew inhibitor in space station environment
  • Long-acting antibacterial mildew inhibitor, preparation method thereof, and application of long-acting antibacterial mildew inhibitor in space station environment

Examples

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Effect test

preparation example Construction

[0027] The present invention provides the preparation method of the long-acting antibacterial antifungal agent described in the above scheme, comprising the following steps:

[0028] Mix organic silicon quaternary ammonium salt, stabilizer, synergist, film-forming agent and water to obtain long-acting antibacterial and antifungal agent.

[0029] In a specific embodiment of the present invention, it is preferable to use commercially available organic silicon quaternary ammonium salt solution as raw material to prepare the antibacterial and antifungal agent of the present invention. When using commercially available organic silicon quaternary ammonium salt solution as raw material, it is preferred to use propylene glycol as The organic silicon quaternary ammonium salt solution of solvent, the mass concentration of described organic silicon quaternary ammonium salt solution is preferably 10~60%, more preferably 50%, when using commercially available organic silicon quaternary ammo...

Embodiment 1

[0035] With organosilicon quaternary ammonium salt solution (solvent is propylene glycol, solute is (trimethoxysilyl) propyl group-N-octadecyl dimethyl ammonium chloride, mass concentration is 50%) as raw material preparation embodiment 1 Antibacterial and antifungal agent, mix organosilicon quaternary ammonium salt solution, chitosan, dopamine hydrochloride, poloxamer and water, stir for 10 minutes, use 0.1% sodium hydroxide solution to adjust the pH value to 8.5, and fill.

[0036] In the obtained product, every 100 g product contains: 0.5 g of organosilicon quaternary ammonium salt, 0.5 g of propylene glycol, 1.0 g of chitosan, 0.2 g of dopamine hydrochloride, 4071.2 g of poloxamer, and the balance of water.

[0037] Stability test: The test temperature is 25°C, and the drug stability test box is placed. The results show that the product can be stored stably at room temperature for more than 2 years.

[0038] Anti-mildew test on the surface of textiles, using Aspergillus ni...

Embodiment 2

[0046] Example 2 was prepared from organosilicon quaternary ammonium salt solution (the solvent is propylene glycol, the solute is (triethoxysilyl) propyl-N-octadecyldimethylammonium chloride, and the mass concentration is 60%) For antibacterial and antifungal agents, mix organosilicon quaternary ammonium salt solution, pentylene glycol, chitosan, dopamine hydrochloride, polyvinylpyrrolidone K30 and water, stir for 10 minutes, and fill.

[0047] In the obtained product, every 100 g of the product contains: 0.2 g of organosilicon quaternary ammonium salt, 0.13 g of propylene glycol, 0.8 g of pentylene glycol, 1.0 g of chitosan, 0.1 g of dopamine hydrochloride, 0.5 g of polyvinylpyrrolidone K, and the balance of water.

[0048] The stability test was carried out according to the method of Example 1, and the results showed that the product could be stored stably at room temperature for more than 1 year.

[0049] Anti-mildew test on aluminum alloy surface, using Aspergillus niger,...

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Abstract

The invention relates to the technical field of antibacterial mildew inhibitors, and provides a long-acting antibacterial mildew inhibitor, a preparation method thereof, and an application of the long-acting antibacterial mildew inhibitor in a space station environment. The long-acting antibacterial mildew inhibitor takes an organosilicon quaternary ammonium salt as a main sterilization component,can inhibit bacteria, saccharomycetes and fungi for a long time, is high in safety, and has no acute toxicity or accumulated toxicity hidden danger; the antibacterial mildew inhibitor has long-actingantibacterial and mildew-proof performance, and bacteria and mildew do not easily generate drug resistance; no color change hidden danger or toxic component exists, and long-term storage can be achieved; and furthermore, propylene glycol and the like are used as stabilizers, so the VOC release amount can be reduced, and the situation that toxic gas such as methyl alcohol volatilizes in the special environment of the space station and affects the health of astronauts is avoided. The long-acting antibacterial mildew inhibitor can meet the long-acting antibacterial and mildew-proof requirementsof aluminum alloy and textiles in a space station cabin, the VOC release amount of the product is low, and the air quality requirement of the space station is met.

Description

technical field [0001] The invention relates to the technical field of antibacterial and antifungal agents, in particular to a long-acting antibacterial and antifungal agent, a preparation method thereof and an application in a space station environment. Background technique [0002] Microorganisms on the space station will affect the health of astronauts and the safety of the cabin environment. Studies have shown that the growth rate of microorganisms on the space station is significantly faster than that of the ground control group. Researchers found 84 kinds of microorganisms in the cabin of the International Space Station, and identified 18 types of bacteria and 12 types of fungi, including 49 types of bacteria and 35 types of fungi. Microorganisms exist in the air, water and surfaces of the Mir space station. In the International Space Station, the fungi attached to the surface of materials are mainly Penicillium, Aspergillus and Cladosporium, all of which have a tend...

Claims

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Application Information

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IPC IPC(8): A01N55/10A01N33/10A01N37/44A01N43/16A01P1/00A01P3/00
CPCA01N33/10A01N37/44A01N43/16A01N55/00
Inventor 王小雪李飞李明刘庆华郭飞马王凯马峰
Owner SHENZHOUSPACEBIOTECHGRP
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