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Method for extracting hesperidin

An extraction method, the technology of hesperidin, which is applied in the field of extraction and preparation of natural plant components, can solve problems such as increasing maintenance costs, generating acid mist, and reducing equipment life, so as to reduce equipment maintenance costs, increase service life, and avoid health risks. Effect

Active Publication Date: 2020-05-01
CHONGQING HOLLEY PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, using hydrochloric acid as a reagent to provide hydrogen ions has many problems: hydrochloric acid is volatile, produces acid mist, has strong irritation, and is easy to cause damage to the skin and respiratory tract of operators; hydrochloric acid is easy to corrode equipment and passivate the surface of materials. It will reduce the life of the equipment and increase the maintenance cost; hydrochloric acid is a precursor reagent, which requires more complicated procedures for purchase and transportation

Method used

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  • Method for extracting hesperidin
  • Method for extracting hesperidin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Take 200kg of fresh young fruit of Fructus Aurantii, pass through a 15-mesh sieve after crushing, and soak in an alkaline alcohol solution for 1 hour (the ratio of solid to liquid is 1kg:0.5L) to obtain raw materials (including liquid and solid) of Fructus Fructus Aurantii. The soaking process was carried out in a continuous infiltrator with an ultrasonic generator, and the ultrasonic power was 300W. Use a continuous countercurrent machine to extract, use alkaline alcohol solution as a solvent to extract, feed the Fructus Fructus Fructus raw material from the feed inlet, the consumption of alkaline alcohol solution is to use 4L per kg of fresh Fructus Fructus Fructus Fructus Aurantii, and the material and extraction solvent are in continuous countercurrent The extraction time in the machine was 5 hours, and the extract containing hesperidin was obtained after the extraction was completed. In this embodiment, the alkali used in the alkaline alcohol solution is sodium hyd...

Embodiment 2

[0035] Take 150kg of fresh young fruit of Fructus Aurantii, pass through a 20-mesh sieve after crushing, and soak in an alkaline alcohol solution for 1 hour (the ratio of solid to liquid is 1kg:0.5L) to obtain raw materials of Fructus Fructus Fructus Fructus (including liquid and solid). The soaking process was carried out in a continuous infiltrator with an ultrasonic generator, and the ultrasonic power was 300W. Use a continuous countercurrent machine to extract, use alkaline alcohol solution as a solvent to extract, feed the Fructus Fructus Fructus raw material from the feed inlet, the consumption of alkaline alcohol solution is to use 3L per kg of fresh Fructus Fructus Fructus Fructus Aurantii, and the material and extraction solvent are in continuous countercurrent The extraction time in the machine was 3 hours, and the extract containing hesperidin was obtained after the extraction was completed. In this embodiment, the alkali used in the alkaline alcohol solution is pot...

Embodiment 3

[0038] Take 300kg of fresh young fruit of Fructus Aurantii, pass through a 15-mesh sieve after being crushed, and soak in an alkaline alcohol solution for 1 h (the ratio of solid to liquid is 1kg:0.5L) to obtain raw materials of Fructus Fructus Fructus Fructus (including liquid and solid). The soaking process was carried out in a continuous infiltrator with an ultrasonic generator, and the ultrasonic power was 300W. Use a continuous countercurrent machine to extract, use alkaline alcohol solution as solvent to extract, feed the Fructus Fructus Fructus raw material from the feed inlet, the consumption of alkaline alcohol solution is to use 5L per kg of fresh Fructus Fructus Fructus Fructus Aurantii, and the material and the extraction solvent are in continuous countercurrent The extraction time in the machine was 6 hours, and the extract containing hesperidin was obtained after the extraction was completed. In this embodiment, the alkali used in the alkaline alcohol solution is...

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Abstract

The invention relates to the field of extraction and preparation of natural components of plants, relates to a natural product extraction method and in particular relates to a method for extracting hesperidin. The method comprises the following steps: by taking an alkali solution as a solvent, extracting an immature bitter orange raw material so as to obtain an extract; and adjusting the pH valueof the extract to acid by using citric acid to generate a crystal in the extract, so as to obtain a hesperidin crystal. By adopting the method, hydrochloric acid is replaced by an organic acid to crystallize and precipitate hesperidin, a hesperidin product of which the quality meets requirements can be obtained, in addition, the production process is environmentally friendly and safe, and the quality of the product can be improved. The scheme can be applied to practical operation of industrial extraction and purification separation of the hesperidin.

Description

technical field [0001] The invention relates to the field of extraction and preparation of plant natural components, and relates to a method for extracting natural products, in particular to a method for extracting hesperidin. Background technique [0002] Hesperidin (hesperidin) widely exists in plants such as citrus aurantium, tangerine peel, and citrus peel. It has antibacterial, antioxidative, cardiovascular disease prevention, whitening, osteoporosis prevention, and anticancer functions. Development and utilization hotspots in daily chemical and other fields. The extraction process of hesperidin mainly includes hot water extraction, alkali extraction and acid precipitation, alcohol extraction and acid precipitation, water extraction and resin adsorption, etc. Due to the difference in extraction methods, the obtained hesperidin has great differences in terms of purity, impurity type, bulk density and biological activity. [0003] In the prior art, alkali extraction and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H17/07C07H1/08
CPCC07H17/07C07H1/08
Inventor 石磊张文平杨婷
Owner CHONGQING HOLLEY PHARMA
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