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Application of meptazinol

A technology of meptafol and action, applied in the field of application of meptafol, can solve the problems such as the unreported action of meptafol

Active Publication Date: 2020-04-28
SUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, meptafol is generally used as an analgesic in clinical practice, and its role in depression has not been reported

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0092] Example 1 Establishment of Stress-Induced Depression Mouse Model

[0093] (1) Fabrication of the spatial behavior restriction device: Take a number of disposable 50ml centrifuge tubes, respectively punch small holes of the same size in the same part of the bottom of the tubes to meet the needs of the mice to breathe, and put cotton on the tube heads to prevent damage to the tails of the mice.

[0094] (2) Model establishment: Male ICR mice were randomly divided into Control group and Stress group. At the same time every day (9:00-11:00 in the morning), the mice in the Stress group were placed in the spatial behavior restriction device, and the spatial behavior restriction was performed for 2 hours, while the Control group was fasted for 2 hours, and the model continued for 21 days .

Embodiment 2

[0095] Example 2 Behavioral Assessment

[0096] Tail suspension test (TST):

[0097] The tail suspension test is an animal experiment widely used to evaluate the depressive behavior of mice. After hanging the mouse tail, the mouse tries to struggle and escape but fails to escape, then gives up the struggle and then appears immobile. By recording the immobile state of the mouse time to reflect the degree of depression. Experimental setup: The tails of mice aged 2-4 months (about 1 cm from the tip of the tail) were glued to a wooden pole with a height of 40 cm. The mice were forced to hang for 6 minutes, and the time during which the mice were immobile during the 6 minutes was recorded. Measurement and statistical personnel are double-blind. In this experiment, the actual distance from the tip of the tail of the depression model and control mice to the table is about 35 cm, and each mouse is suspended by its tail for 6 minutes. Use a stopwatch to record the immobility time of...

Embodiment 3

[0109] Embodiment 3 Intraperitoneal injection (i.p.) gives mebutaol (Mep) treatment

[0110] After the modeling was completed, the mice were injected intraperitoneally at a dose of 10 mg / kg, and the control group was given normal saline (NS), while continuing to restrict spatial behavior every day at 12 noon for two consecutive weeks.

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Abstract

The invention relates to the field of medicines, and in particular to the application of meptazinol. According to the application of the meptazinol disclosed by the invention, the experiment indicatesthat the meptazinol can achieve the effect of resisting depression through raising the level of Ahi1. Depression resisting model mice are constructed through chronic stress, and then the changes of Ahi1 protein are observed; and the result shows that after 21-day continuous space behavior limit is given to the mice, the depression sample ethology change of the mice is detected through a tail suspension test and a forced swimming test. After the model is successfully constructed, the mice are subjected to intraperitoneal injection according to the dosage of 10mg / kg, physiological saline (NS) is given to the control group, at the same time, space behavior limit is continuously performed each day, the medicine administration time is 12 o'clock at noon and medicine administration is performedfor two weeks continuously; then the depression sample ethology change of the mice is detected by the tail suspension test and the forced swimming test; and then through detection by a Western Blot method, the inventor finds that compared with the Ahi1 protein level of hippocampus of a medicine administration group, the Ahi1 protein level of hippocampus of the depression model mice is notably reduced.

Description

technical field [0001] The invention relates to the field of medicine, in particular to the application of mebutamol. Background technique [0002] Depression is an attack form of manic depression, with low emotion, slow thinking, and decreased speech and movement, slowness as typical symptoms. Depression seriously plagues the life and work of patients, and brings a heavy burden to families and society. About 15% of patients with depression die by suicide. A joint study by the World Health Organization, the World Bank and Harvard University shows that depression has become the second largest disease burden in China. [0003] Depressive episodes often have a tendency to recur. Therefore, the goals of treatment are twofold: controlling acute attacks and preventing relapses. Depressive episodes often have a tendency to recur. Therefore, the goals of treatment are twofold: controlling acute attacks and preventing relapses. 1. Drug selection: At present, TCAS is still used a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/55A61P25/24
CPCA61K31/55A61P25/24
Inventor 徐兴顺苗志刚刘倍倍潘恺凌
Owner SUZHOU UNIV
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