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Application of jak-1 signal pathway inhibitor in preparation of medicine for treating brain injury

A technology of JAK-1 and signaling pathways, applied in the field of biomedicine, can solve problems such as secondary damage and damage, achieve the effect of reducing the degree of neuron degeneration, reducing brain edema, and improving nerve function damage

Active Publication Date: 2021-08-31
SUZHOU UNIV
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  • Summary
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  • Description
  • Claims
  • Application Information

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Problems solved by technology

Also, the damage from secondary injuries appears to be more severe and long-lasting

Method used

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  • Application of jak-1 signal pathway inhibitor in preparation of medicine for treating brain injury
  • Application of jak-1 signal pathway inhibitor in preparation of medicine for treating brain injury
  • Application of jak-1 signal pathway inhibitor in preparation of medicine for treating brain injury

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Embodiment 1

[0043] Sixty-six 6-8-week-old male C57 / BL6J mice (20-25g) with basically the same body weight were randomly divided into three groups, 22 in each group, respectively: control group (Sha group), Vehicle treatment craniocerebral injury group ( Vehicle group), Ruxolitinib treatment craniocerebral injury group (RUXO group).

[0044] The mice in the control group were fed normally without any treatment. The modeling steps of Vehicle group and RUXO group are as follows:

[0045]The mice in each group were fixed with a stereotaxic instrument, the mouse scalp was cut to expose the skull, the coronal suture and the sagittal suture tangent line were on both sides, and a circular hole with a diameter of 4mm was drilled in the left hemisphere to expose the brain tissue. Then use the air pressure impact quantitative cortical striker to strike to establish a craniocerebral injury model. The Vehicle group was intraperitoneally injected with 0.01% DMSO (0.2 mL) within 30 minutes after crani...

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Abstract

The invention relates to the application of JAK-1 signaling pathway inhibitors in the preparation of drugs for treating brain injury and / or protecting brain nerves. Inhibitors of the JAK‑1 signaling pathway (one of which is Ruxolitinib, a clinical drug approved by the FDA for the treatment of myelofibrosis) exert neuroprotective effects by (but not limited to) inhibiting the process of pyroptosis. Injured patients provide new theoretical and technical means.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to the application of a JAK-1 signaling pathway inhibitor in the preparation of a drug for treating brain injury. Background technique [0002] At present, craniocerebral injury is very common clinically, such as traumatic brain injury (traumatic brain injury, TBI), which has a high mortality and disability rate, and is especially common in young people, causing a great burden to society. Conditions following brain injury are rapid, complex, and prolonged. Although the drugs and surgical operations for the treatment of brain injury are improving day by day, effective treatment methods and means are quite scarce, especially the lack of drug treatment means. Therefore, it is imperative to fully study the pathological changes after brain injury in order to seek better treatments. [0003] Taking traumatic brain injury as an example, its pathogenesis is mainly divided into two types, one is...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/519A61P25/00
CPCA61K31/519A61P25/00
Inventor 陶陆阳高诚陈溪萍鄢亚南陶泓旭
Owner SUZHOU UNIV
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