Traditional Chinese medicine composition for treating chronic nephritis proteinuria and preparation method and application thereof

Abstract

The invention discloses a traditional Chinese medicine composition for treating chronic nephritis proteinuria and a preparation method and application thereof. The traditional Chinese medicine composition of the invention has both spleen tonifying and kidney reinforcing functions and both tonifying and astringency inducing effects, and is assisted by a small amount of dampness-excreting ingredients so as to exert spleen and kidney tonifying, qi benefiting, essence securing, pathogen eliminating, and body resistance strengthening effects. The traditional Chinese medicine composition is preparedfrom the following bulk drugs by weight: 30-50 parts of astragalus membranaceus, 20-30 parts of mantis egg-case, 15-20 parts of bighead atractylodes rhizome, 15-20 parts of semen cuscutae, 10-15 parts of schisandra chinensis, 10-15 parts of dogberry, 10-15 parts of poria cocos and 10-15 parts of honey-fried licorice roots. Clinical application proves that the traditional Chinese medicine composition can improve the clinical symptoms of patients with chronic nephritis; pharmacodynamic studies show that the composition can reduce 24-hour urine protein quantification of a cationized bovine serumalbumin (C-BSA) induced chronic nephritis model and reduce the content of serum urea nitrogen and creatinine in rats, is suitable for long-term administration of chronic nephritis patients with spleen-kidney qi deficiency syndromes, and has wide clinical application value and guiding significance.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition, in particular to a traditional Chinese medicine composition for treating chronic nephritis proteinuria, a preparation method and application thereof. Background technique [0002] Proteinuria is widely present in chronic nephritis and is one of the most common diagnostic indicators of chronic nephritis. Proteinuria not only reflects the degree of kidney damage, but also continuously aggravates kidney damage. Modern research has also proved that reducing urinary protein can delay the progression of renal failure. A meta-analysis involving 1860 people showed that in patients with chronic kidney disease, proteinuria is the most important modifiable factor that can delay the progression of renal insufficiency, and the reduction of urinary protein excretion should be the most important goal in the treatment of chronic k...

AI Technical Summary

Problems solved by technology

Relevant studies have also proved that ACEI antihypertensive drugs can reduce urinary protein excretion, but they need to be used in excess doses, resulting in a large number of patients who cannot tolerate them

The field of traditional Chinese medicine has also conducted extensive research on proteinuria, and achieved certain effects, but it is only effective for a small number of patients, and most patients still have poor results or recurrent recurrences. Potential, worthy of in-depth study

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