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Titanium implant material with anti-infection and osseointegration promoting functions, and preparation method thereof

A technology of implants and osseointegration, applied in prosthetics, medical science, tissue regeneration, etc., can solve rare problems and achieve the effect of promoting proliferation, high efficiency, and mild reaction conditions

Active Publication Date: 2020-04-21
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to its highly branched structure and a large number of terminal residues, hyperbranched polylysine is more common in the study of gene carriers, but hyperbranched polylysine is used as an antibacterial and enhances the biological activity of implants. research, less common

Method used

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  • Titanium implant material with anti-infection and osseointegration promoting functions, and preparation method thereof
  • Titanium implant material with anti-infection and osseointegration promoting functions, and preparation method thereof
  • Titanium implant material with anti-infection and osseointegration promoting functions, and preparation method thereof

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Embodiment 1

[0030] The antibacterial and osseointegration-promoting functional surface construction of titanium implants includes the following steps:

[0031] 1) Synthesis of hyperbranched polylysine: First, slowly add KOH solution dropwise to lysine hydrochloride solution, the molar ratio of lysine hydrochloride to KOH is 1:1, react at 40°C for 4-5h; Next, raise the temperature to 150°C, protect it with nitrogen, and keep stirring for 2-3 days. During this period, the water in the reaction system is maintained in due course, and the melt gradually changes from white to yellow to reddish brown; finally, stop heating, and add methanol to dissolve the melt , and then convert the solvent into water, dialyze for 3-5d, freeze, and dry to obtain.

[0032] 2) Alkaline heat treatment of titanium surface: Ultrasonic cleaning of pure titanium in acetone, absolute ethanol, and ultrapure water for 10 minutes, then immersing in 10mol / L sodium hydroxide solution, reacting at 80°C for 1 hour, taking it...

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Abstract

The invention relates to a titanium implant material with anti-infection and osseointegration promoting functions, and a preparation method thereof. According to the method, hyperbranched polylysine (HBPL) is prepared through a thermal initiation one-pot method; HBPL is covalently grafted to a titanium sheet by using a silane coupling agent gamma-(2,3-epoxypropoxy)propyltrimethoxysilane (GPTMS); the hyperbranched polylysine fixed on the surface of the titanium sheet has good sterilization effects on gram-positive staphylococcus aureus and gram-negative escherichia coli; and compared with puretitanium, the material can promote the adhesion, the proliferation and the differentiation of osteoblasts, and does not have cytotoxicity. According to the invention, the titanium implant material issimple in technological process and low in production cost, has the functions of infection resistance and osseointegration promoting on the basis of good safety, innovatively applies hyperbranched polylysine to the field of implants, has important significance in modification of titanium implants, and has good application prospect.

Description

technical field [0001] The invention belongs to the field of biomedical materials, in particular to an antibacterial and osseointegrated hyperbranched polylysine-modified titanium implant material and a preparation method thereof. Background technique [0002] Titanium and titanium alloy implant materials, due to their good biocompatibility and excellent biomechanical properties, are widely used in orthopedic and dental operations such as dental implants and bone repairs, and have good application prospects. Infection and loosening are the most important reasons for implant failure. However, since titanium itself does not have the function of anti-infection, and after the titanium material body is implanted in the body, it will be mechanically integrated with the bone, which will easily cause inflammation and loosening, and eventually lead to implant failure. In order to solve this problem, the development of titanium implant materials with both antibacterial and osseointeg...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/06A61L27/54A61L27/18
CPCA61L27/06A61L27/18A61L27/54A61L2300/216A61L2300/404A61L2430/02C08L77/04
Inventor 高长有杨志坚白俊张昊岚
Owner ZHEJIANG UNIV
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