Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Application of Geum japonicum Thunb extract in preparation of medicine for preventing and treating autoimmune diseases

An autoimmune disease and extract technology, applied in the field of medicine, can solve the problems of high number of people, unable to provide pathological lesions, etc., and achieve the effect of restoring function

Inactive Publication Date: 2020-04-14
BEIJING LVYUAN QIUZHENG SCI & TECH DEV
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the number of people afflicted by various autoimmune and aforementioned diseases remains alarmingly high
Moreover, currently available treatment regimens, drugs, and approaches are largely supportive and symptomatic, which do not provide treatment that can improve pathological lesions

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of Geum japonicum Thunb extract in preparation of medicine for preventing and treating autoimmune diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] This embodiment provides a kind of preparation method of blue cloth positive extract, and it comprises the following steps:

[0027] (1) In July, the blue cloth was collected from Guizhou Province, China, and the blue cloth was ventilated and dried in the shade for future use.

[0028] (2) Take 50 kg of the above-mentioned treated blue cloth and place it in 100 L of methanol for soaking and extraction for 6 hours, then add 50 L of water to continue soaking and extracting for 6 hours, repeat the above steps twice, and combine the extracts to obtain an alcohol extract.

[0029] (3) Put the above alcohol extract at 40° C. for constant temperature and reduced pressure concentration treatment, and then spray drying treatment to obtain solid powder.

[0030] (4) Dissolve the above solid powder in 50L of water, first extract with 100L of ethyl acetate, and remove the ethyl acetate extract, then extract with 50L of n-propanol to obtain an alcohol extract.

[0031] (5) Place th...

Embodiment 2

[0033] This embodiment provides a kind of preparation method of blue cloth positive extract, and it comprises the following steps:

[0034] (1) In July, the blue cloth was collected from Guizhou Province, China, and the blue cloth was ventilated and dried in the shade for future use.

[0035] (2) Take 50kg of blue cloth after the above-mentioned treatment and place it in 200L of n-propanol for soaking and extraction for 6h, then add 300L of water to continue soaking and extracting for 6h, repeat the above steps for 3 times, combine the extracts, and obtain alcohol extraction liquid.

[0036] (3) Put the above alcohol extract at 60° C. for constant temperature and reduced pressure concentration treatment, and then perform spray drying treatment to obtain solid powder.

[0037] (4) The above solid powder was dissolved in 50L of water, first extracted with 100L of ethyl acetate, and after removing the ethyl acetate extract, extracted with 50L of n-butanol to obtain an alcohol ex...

Embodiment 3

[0040] This embodiment provides a kind of preparation method of blue cloth positive extract, and it comprises the following steps:

[0041] (1) In July, the blue cloth was collected from Guizhou Province, China, and the blue cloth was ventilated and dried in the shade for future use.

[0042] (2) Take 50 kg of the above-mentioned treated blue cloth and place it in 150 L of ethanol for soaking and extraction for 6 hours, then add 150 L of water to continue soaking and extracting for 6 hours, repeat the above steps for 3 times, combine the extracts to obtain the alcohol extract.

[0043] (3) Put the above alcohol extract at 50° C. for constant temperature and reduced pressure concentration treatment, and then perform spray drying treatment to obtain solid powder.

[0044](4) The above solid powder was dissolved in 50L of water, first extracted with 100L of ethyl acetate, and after removing the ethyl acetate extract, extracted with 50L of n-butanol to obtain an alcohol extract. ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses application of a Geum japonicum Thunb extract in preparing a medicine for preventing and treating autoimmune diseases, and belongs to the technical field of medicines. A preparation method of the Geum japonicum Thunb extract comprises the following steps: soaking and extracting Geum japonicum Thunb in first alcohol, adding water, and continuing soaking and extracting to obtain an alcohol extracting solution; carrying out vacuum concentration treatment on the alcohol extracting solution, and then carrying out spray drying treatment to obtain solid powder; dissolving thesolid powder in water, extracting by using ethyl acetate, removing an ethyl acetate extracting solution, and extracting by using second alcohol to obtain an alcohol extracting solution; and carrying out reduced pressure drying treatment on the alcohol extracting solution, and then sequentially carrying out freeze drying treatment and grinding treatment to obtain the Geum japonicum Thunb. The Geumjaponicum Thunb extract has remarkable prevention and treatment effects on autoimmune diseases such as ulcerative colitis, regional enteritis, proctitis, bacillary dysentery, enteritis, gastric ulcer,rheumatoid arthritis and the like.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the application of bluebud extract in the preparation of medicines for preventing and treating autoimmune diseases. Background technique [0002] Ulcerative colitis is an inflammatory process that occurs mostly in the 20-30 age group and is limited to the colonic mucosa and submucosa. The lesions are mostly located in the sigmoid colon and rectum, and can also extend to the descending colon, or even the entire colon. The pathology is long and often recurrent. The intestinal mucosa showed diffuse inflammation, and the normal mucosa was basically invisible, showing continuous lesions, and the muscularis propria of the intestinal wall was not obviously involved. Therefore, ulcers are generally not deep, and will not cause perforation, fistula, stenosis, or obstruction. The etiology of the disease is unknown, but it is considered to be related to genetic factors (susceptibility i...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K36/73A61P37/02A61P29/00A61P19/02A61P1/04A61P1/00
CPCA61K36/73A61K2236/333A61K2236/51A61K2236/55A61P1/00A61P1/04A61P19/02A61P29/00A61P37/02Y02A50/30
Inventor 李明
Owner BEIJING LVYUAN QIUZHENG SCI & TECH DEV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com