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A protein film dressing based on three bioactive scaffold materials and synergistic cytotrophic factors for wound healing

A scaffold material, cell nutrition technology, applied in bandages, medical science and other directions, can solve the problems of prolonged wound inflammation, poor wound healing quality, allergic inflammation, etc., to prevent skin oxidation and pigmentation, epithelial repair fast, reduce The effect of scarring

Active Publication Date: 2022-07-01
杭州伊瑟奇生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Wound dressings have relatively high requirements on the biocompatibility and bioactivity of wound repair materials, and there are not many suitable materials. Many protein film dressings on the market come from a single source. The amino acid signal sequence cannot guarantee the effect, and the process is immature, so it cannot be produced on a large scale
Some dressings on the market even add crude Chinese herbal medicines, which can easily cause allergic inflammation in the early stage, prolong the inflammatory period of the wound, and the healing quality of the wound in the later stage is very poor, and it is easy to cause pigmentation

Method used

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  • A protein film dressing based on three bioactive scaffold materials and synergistic cytotrophic factors for wound healing
  • A protein film dressing based on three bioactive scaffold materials and synergistic cytotrophic factors for wound healing
  • A protein film dressing based on three bioactive scaffold materials and synergistic cytotrophic factors for wound healing

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] A protein film dressing based on three kinds of bioactive scaffold materials and cytotrophic factors to help wound healing, is composed of the following components by mass percentage: 15% of keratin, 50% of oxidized keratin, and 0.05% of schizotocin powder %, pluripotent stem cell conditioned culture supernatant 10%, chlorella extract 1%, glycerol glucoside 5%, chitosan powder 0.05%, Leuconostoc / radish root fermentation product filtrate 1%, glycerol 2% %, water 15.9%.

[0032] Patient 1 has a medical history of more than 20 years, the wound on the arm has not healed, the affected area is red and swollen, the epidermis is damaged, and there is occasional exudation; using the protein film dressing prepared in this example, after one month of treatment, the effect is comparable to figure 1 It can be seen that the wound has scabbed over.

Embodiment 2

[0034] A protein film dressing based on three kinds of bioactive scaffold materials and cytotrophic factors to help wound healing, is composed of the following components by mass percentage: 50% keratin, 10% oxidized keratin, and schizophrenia powder 1 %, pluripotent stem cell conditioned culture supernatant 6%, chlorella extract 5%, glycerol glucoside 10%, chitosan powder 0.2%, Leuconostoc / radish root fermentation product filtrate 5%, glycerol 3% %, water 9.8%.

[0035] The back of patient 2 has multiple skin injuries, showing redness and swelling, and it is sometimes accompanied by itching according to oral description. There is a history of 20 years, and the wound has never healed; using the protein film dressing prepared in this example, after one month of treatment, the effect like figure 2 shown, the wound has healed completely, with slight redness, and the skin can repair itself.

Embodiment 3

[0037] A protein film dressing based on three kinds of bioactive scaffold materials and cytotrophic factors to help wound healing, is composed of the following components by mass percentage: keratin 20%, oxidized keratin 30%, schizophrenia powder 0.2% %, pluripotent stem cell conditioned culture supernatant 1%, chlorella extract 25%, glycerol glucoside 2%, chitosan powder 0.8%, Leuconostoc / radish root fermentation product filtrate 3%, glycerol 4% %, water 14%.

[0038] The wound on the patient's 3 hands belongs to chronic wounds and has not healed in 3 years; the effect of using the protein film dressing prepared in this example after 2 days is as follows: image 3 It can be clearly seen that after 2 days of treatment, the skin is still a little red, but it is no longer red and swollen, and the wound has healed.

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Abstract

The present invention provides a protein film dressing based on three kinds of bioactive scaffold materials that cooperate with cytotrophic factors to help wound healing. , Chlorella extract, glycerol glucoside, chitosan powder, Leuconostoc / radish root fermentation product filtrate, glycerol, water. The protein film dressing provided by the invention is rich in functionally important physiological structural proteins and biological polysaccharides, as well as various nutritional factors and growth factor groups required by cells, is closer to the protein source of the human body, and does not cause immune rejection; it is helpful for acute wounds Quick recovery, can quickly coagulate, stop exudation, and anti-inflammatory; for chronic wounds, it can change from the inflammatory stage to the repair stage, preventing skin oxidation and pigmentation caused by free radicals.

Description

technical field [0001] The invention relates to the field of biological products, in particular to a protein film dressing based on three kinds of bioactive scaffold materials and cell trophic factors to help wound healing and the application of the protein film dressing in the medical field. Background technique [0002] An in-depth understanding of the pathophysiological mechanisms of wound healing can improve the level of wound care, and the exploration and optimization of materials is expected to lead to more efficient wound care solutions. Wound healing is one of the most complex processes in multicellular organisms, involving numerous signaling within and between multiple cells. Physical, chemical and cytokines are involved in biological processes with wound repair as the main goal. The healing mechanisms of skin wounds can be divided into repair and regeneration, and there is a clear and important distinction between the two types of healing. The characteristics and...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L26/00
CPCA61L26/0066A61L26/0047A61L26/0023A61L26/0057A61L2300/412A61L2300/214A61L2300/30A61L2300/414A61L2300/41A61L2300/418
Inventor 朱国君罗晓丹
Owner 杭州伊瑟奇生物科技有限公司
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