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Tissue engineering nerve graft with suspension fiber scaffold and preparation method thereof

A fibrous scaffold and tissue engineering technology, which is applied in the fields of medicine and biomedical engineering, can solve the problems of affecting the treatment effect, the difficulty of uniform distribution of microfilaments, and the limited effect of orientation and guidance, so as to achieve improved success rate, low cost, and avoid Effects of the immune tissue response

Active Publication Date: 2015-05-20
NANTONG UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the nerve grafts of the prior art, it is difficult to evenly distribute the microfilaments in the catheter inside the catheter, and the microfilaments as "bridges" are easy to gather together, so in practical applications, the role of directional guidance is very limited , affecting the therapeutic effect

Method used

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  • Tissue engineering nerve graft with suspension fiber scaffold and preparation method thereof
  • Tissue engineering nerve graft with suspension fiber scaffold and preparation method thereof
  • Tissue engineering nerve graft with suspension fiber scaffold and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] (1) the benzoic acid solution 50ml (benzoic acid solution concentration of 0.1mol / L) of preparation 3% polylactic acid is contained in the ink cartridge that model is HP51626A;

[0053] (2) Adjust the printer nozzle needle diameter to 2μm, the number of needles to 4, the distance from the nozzle to the bottom layer to 10mm, and the booster pulse frequency to 1v;

[0054] (3) Accurately simulate the three-dimensional spatial structure of different nerves, compile corresponding control programs, preset the three-dimensional model of the printer, and design the shape of tissue-engineered nerve grafts: tissue-engineered nerve grafts include catheters and intratube fiber scaffolds, such as image 3 , Figure 4 As shown, each fiber support is provided with a number of suspension wires along the fiber length direction to connect with the inner wall of the catheter, and the fiber support is suspended in the catheter through the distribution of suspension wires. The connection ...

Embodiment 2

[0062] (1) 50ml of citric acid solution (concentration of citric acid solution is 0.05mol / L) of preparing 5% sodium alginate is contained in the ink cartridge that model is HP51626A;

[0063] (2) Adjust the printer nozzle needle diameter to 100 μm, the number of needles to 16, the distance from the nozzle to the bottom layer to 25mm, and the booster pulse frequency to 15v;

[0064] (3) Accurately simulate the three-dimensional space structure of different nerves, compile the corresponding control program, preset the three-dimensional model of the printer, and design the shape of the tissue-engineered nerve graft: the tissue-engineered nerve graft includes a catheter and a fiber scaffold in the tube, such as image 3 , Figure 4As shown, each fiber support is provided with a number of suspension wires along the fiber length direction to connect with the inner wall of the catheter, and the fiber support is suspended in the catheter through the distribution of suspension wires. ...

Embodiment 3

[0072] (1) 50ml of acetic acid solution (concentration of acetic acid solution is 0.1mol / L) of preparing 5% chitosan is contained in the ink cartridge that model is HP51626A;

[0073] (2) Adjust the printer nozzle needle diameter to 50 μm, the number of needles to 9, the distance from the nozzle to the bottom layer to 40mm, and the booster pulse frequency to 10v;

[0074] (3) Accurately simulate the three-dimensional spatial structure of different nerves, compile corresponding control programs, preset the three-dimensional model of the printer, and design the shape of tissue-engineered nerve grafts: tissue-engineered nerve grafts include catheters and intratube fiber scaffolds, such as image 3 , Figure 4 As shown, each fiber support is provided with a number of suspension wires along the fiber length direction to connect with the inner wall of the catheter, and the fiber support is suspended in the catheter through the distribution of suspension wires. The connection positi...

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Abstract

The invention discloses a tissue engineering nerve graft with a suspension fiber scaffold. The nerve graft comprises a conduit and tube fiber scaffolds. The nerve graft is characterized in that a plurality of suspensions are arranged on each fiber scaffold along the fiber length direction, and are connected with the inner wall of the conduit; and the fiber scaffolds are distributed and suspended in the conduit by virtue of the suspensions. By utilizing bio-printing technology, built-in microfilaments of a tissue engineering nerve graft can be stably and uniformly distributed in the conduit by utilizing the supporting force of the suspensions, and each fiber scaffold has an independent space to guarantee that nerve cells can directionally grow along the fiber scaffolds and cannot have error bridging, so that the success rate of operations can be greatly improved.

Description

technical field [0001] The invention relates to the fields of medicine and biomedical engineering, in particular to a tissue engineered nerve graft with suspension fiber support and a preparation method thereof. Background technique [0002] In the real world, traffic accidents, work accidents, sports accidents, earthquakes, wars, and clinical operations will all cause peripheral nerve damage. Clinically, long-distance nerve defects cannot be compensated for by end-to-end sutures. Don't rely on a graft to bridge the repair. At present, autologous nerve transplantation is still the best way to treat these diseases clinically. Due to the limited source of autologous nerves for transplantation, new trauma, difficulty in matching tissue structure and size, and long-term denervation of the donor site, the application of autologous nerve transplantation is very limited. In recent years, tissue engineering based on the principles and technologies of life science and engineering h...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/54A61L27/50A61F2/02
Inventor 杨宇民顾晓松丁斐刘炎刘梅王勇军
Owner NANTONG UNIVERSITY
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