Synthetic method of polyaspartic acid derivative grafted with glycyl histidyl lysine
A technology of glycyl histidyl lysine acetate and glycyl histidyl lysine, which is applied in the field of preparation of polyaspartic acid derivatives, can solve application limitations and limited functionality of polyamino acids and other problems, to achieve the effect of stimulating skin tissue repair, simple and green synthesis steps, and increasing grafting rate
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Embodiment 1
[0027] Purification of glycyl histidyl lysine: choose 50 parts of crude glycyl histidyl lysine synthesized by liquid phase method and dissolve it in 500 parts of ultrapure water, and dissolve it with ultrasonic wave. After the solution is completely clarified, use Filter through a 0.35 μm microporous membrane and collect the filtrate. The obtained filtrate uses a strong cation exchange column to remove trifluoroacetic acid and some impurities, and converts it into an acetate solution. The obtained acetate solution was desalted and purified using a reverse-phase polymer column, and finally the target fraction was collected, concentrated by distillation under reduced pressure, and freeze-dried to obtain pure glycyl-histidyl-lysine.
[0028] Synthesis of polyaspartic acid salt solution grafted with glycyl histidyl lysine: add 100 parts of L-aspartic acid into the kneading reactor, raise the temperature to 175°C, and control it under the condition of vacuum degree -20KPa After 4 ...
Embodiment 2
[0030] Purification of glycyl histidyl lysine: choose 40 parts of crude glycyl histidyl lysine synthesized by liquid phase method and dissolve it in 400 parts of ultrapure water, and ultrasonically assist the dissolution. After the solution is completely clarified, use Filter through a 0.45 μm microporous membrane and collect the filtrate. The obtained filtrate uses a strong cation exchange column to remove trifluoroacetic acid and some impurities, and converts it into an acetate solution. The obtained acetate solution was desalted and purified using a reverse-phase polymer column, and finally the target fraction was collected, concentrated by distillation under reduced pressure, and freeze-dried to obtain pure glycyl-histidyl-lysine.
[0031] Synthesis of polyaspartic acid salt aqueous solution grafted with glycyl histidyl lysine: add 200 parts of L-aspartic acid into the kneading reactor, raise the temperature to 185°C, and control it under the condition of vacuum degree -35...
Embodiment 3
[0033] Purification of glycyl histidyl lysine: select 30 parts of crude glycyl histidyl lysine synthesized by liquid phase method and dissolve it in 300 parts of ultrapure water, and dissolve it with ultrasonic wave. After the solution is completely clarified, use Filter through a 0.45 μm microporous membrane and collect the filtrate. The obtained filtrate uses a strong cation exchange column to remove trifluoroacetic acid and some impurities, and converts it into an acetate solution. The obtained acetate solution was desalted and purified using a reverse-phase polymer column, and finally the target fraction was collected, concentrated by distillation under reduced pressure, and freeze-dried to obtain pure glycyl-histidyl-lysine.
[0034] Synthesis of polyaspartic acid salt aqueous solution grafted with glycyl histidyl lysine: add 120 parts of L-aspartic acid into the kneading reactor, raise the temperature to 195°C, and control it under the condition of vacuum degree -50KPa ...
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