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Application of secretory protein Caspase1 in early myocardial infarction diagnostic reagent

A technology for secreting proteins and diagnostic reagents, which is applied in the field of biomedicine, and can solve problems such as missed detections, and achieve the effects of avoiding missed detections, stable and reliable results, and direct detection results

Inactive Publication Date: 2020-04-10
TONGJI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The accuracy of this method needs to be improved, and it is prone to missed detection

Method used

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  • Application of secretory protein Caspase1 in early myocardial infarction diagnostic reagent
  • Application of secretory protein Caspase1 in early myocardial infarction diagnostic reagent
  • Application of secretory protein Caspase1 in early myocardial infarction diagnostic reagent

Examples

Experimental program
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Embodiment

[0031] Modeling of animal experiments: In the present invention, in order to search for proteins and genes that undergo significant changes in the process of myocardial infarction, the model mouse c57 was used to construct a myocardial infarction model. First, the myocardial infarction model was constructed by ligating the left anterior descending coronary artery. figure 1 A physical map was constructed for the myocardial infarction model in this example. After the ligation, the heart tissue at the apex (the position indicated by the white arrow) was obviously whitish, indicating that the blood supply to the heart in this area was significantly reduced after the operation, indicating that the model was constructed successfully.

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Abstract

The invention relates to application of secretory protein Caspase1 in an early myocardial infarction diagnostic reagent, the amino acid sequence of the secretory protein Caspase1 is shown as SEQ ID NO.1, and during specific detection, after myocardial damage, the content of the secretory protein Caspase1 in peripheral blood is increased. Compared with the prior art, the diagnostic reagent providedby the technical scheme of the invention is beneficial to early diagnosis; the severity degree of myocardial damage can be reflected; the diagnostic reagent can be used as an index for early myocardial infarction diagnosis and prediction, the detection method is simple and easy to operate, the detection sensitivity is good, the system error is small, and the application of the secretory protein Caspasel1 coded by the CASP1 gene in myocardial damage diagnosis reagents can be widely popularized. The kit disclosed by the invention is simple in detection method, low in cost, direct and reliable in detection result and suitable for large-scale screening and diagnosis.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to the application of secreted protein Caspase1 in early myocardial infarction diagnostic reagents. Background technique [0002] Currently, the main biochemical markers for detection of acute myocardial infarction (AMI) are creatine phosphokinase isoform (CK-MB), lactate dehydrogenase (LDH), cardiac troponin (cTnT) and cardiac troponin I (cTnI). Wait. CK-MB and LDH are widely distributed in the body, so their specificity is low, and many diseases can cause their elevation, and their maintenance time in the blood is short; High, prone to cross-reaction. cTnI has the advantages of high specificity, early appearance, high sensitivity, and long duration in the blood, and can be used as an early diagnostic indicator for AMI. Therefore, the current kit detection methods mainly focus on cardiac troponin I (cTnI). [0003] The detection methods of cardiac troponin I (cTnI) include enzyme-link...

Claims

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Application Information

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IPC IPC(8): G01N33/68G01N21/31
CPCG01N21/31G01N33/6893
Inventor 李觉
Owner TONGJI UNIV
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