Microfluidic pulmonary alveolus chip and pulmonary alveolus respiration simulation device

Abstract

The invention discloses a microfluidic pulmonary alveolus chip and a pulmonary alveolus respiration simulation device. The microfluidic pulmonary alveolus chip comprises a microfluidic channel, a gascavity and a simulated pulmonary alveolus, wherein the microfluidic channel comprises a simulated pulmonary alveolus pipeline, an auxiliary liquid inlet channel and an auxiliary liquid storage channel, a fluid inlet and a fluid outlet are formed in two ends of the simulated pulmonary alveolus pipeline, the fluid inlet communicates with the auxiliary liquid inlet channel, the fluid outlet communicates with the auxiliary liquid storage channel, a liquid inlet is formed in the auxiliary liquid inlet channel, a gas inlet / outlet is formed in the gas cavity, the simulated pulmonary alveolus comprises an inner cavity and an elastic side wall, the inner cavity is communicated with the simulated pulmonary alveolus pipeline; and the simulated pulmonary alveolus is arranged in the gas cavity. According to the invention, the micro-fluidic pulmonary alveolus chip is simple in structure, and parameters can be independently controlled by adopting a micro-fluidic chip with a single pulmonary alveolusstructure so as to independently research a complex flow field in each level of pulmonary alveolus, so that mutual interference and mutual restriction among all levels of flows are avoided, and the research accuracy is improved.

Description

technical field [0001] The invention relates to the technical field of biomedical equipment, in particular to a microfluidic alveolar chip and an alveolar respiration simulation device. Background technique [0002] The main function of human respiration is to provide oxygen to various tissues of the body and remove carbon dioxide waste gas. The respiration process of the human body can be divided into two stages: the gas is delivered from the external environment to the blood; the gas enters various tissues through the blood. With the continuous progress of society and economy, human beings have continuously improved the quality requirements of the living environment, and their awareness of the protection of the living environment has gradually increased. Particulate pollution caused by industrial production and environmental degradation has become one of the important indicators for evaluating the quality of life and air quality. In atmospheric aerosol particle pollution,...

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Problems solved by technology

However, the structure of the above five levels of alveolar tree structure is relatively complex, and the size of alveolar ducts and alveoli at each level is the same, while the real alveolar tree structure decreases with the increase of alveolar levels, the diameter of alveolar ducts decreases, and the diameter of alveoli increases. Therefore, the existing The five-level alveolar tree structure does not conform to the real situation of the human alveolar tree structure, and the overall research is inaccurate; in addition, because the alveolar ducts at all levels are connected, the flows of each level interfere and restrict each other, the existing five-level alveolar tree structure and the real structure Inconsistency will cause the flow in the alveolar ducts at all levels to not be precisely controlled to match the actual situation, and some important phenomena, such as chaotic flow, will be ignored; and the breathing process control of the existing five-level alveolar tree branch structure is relatively complicated

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