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Flavored Xiaobupleurum granules and preparation method thereof

A technology of Xiao Chai Hu granules and Chai Hu, which can be applied to pharmaceutical formulations, medical preparations with non-active ingredients, and medical preparations containing active ingredients, etc. achieve the effect of improving the efficacy of the drug

Active Publication Date: 2021-09-10
东莞市中医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, with the historical changes such as the long span of time, huge differences in geographical environments, and differences in human physique, classic prescriptions are far from meeting the needs of modern diseases.
[0003] At the same time, the current traditional Chinese medicine has complex chemical components and difficult quality control, and the prior art Xiaobupleurum is often considered to have low active ingredients and low purity, thereby reducing the efficacy of the medicine.
In order to increase the content of active ingredients of traditional Chinese medicines in the prior art, a variety of solubilization methods have been adopted. However, different solubilization methods also have certain defects, such as the method of using surfactant compounds used in emulsification, which has the advantages of adding There are hidden dangers of severe toxicity and side effects; another example is the method of using phospholipid complex coating, which is prone to drug leakage and poor stability; another example is the method of cyclodextrin embedding, which has low drug loading and has characteristics on the size of drug molecules. asked questions

Method used

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  • Flavored Xiaobupleurum granules and preparation method thereof
  • Flavored Xiaobupleurum granules and preparation method thereof
  • Flavored Xiaobupleurum granules and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] Embodiment 1, a kind of Xiao Bupleurum composition with flavoring

[0056] The flavored Xiao Bupleurum composition is made from the following raw materials by weight:

[0057] Bei Bupleurum 250g; Scutellaria baicalensis 167g; Codonopsis 167g; Pinellia 167g; Ginger 167g;

[0058] The preparation method of the flavored Xiao Bupleurum composition comprises the following steps:

[0059] S1) Take the formula amount of Bupleurum bupleurum, Scutellaria baicalensis, Codonopsis pilosula, Pinellia chinensis, ginger, jujube, licorice, dried ginger, Coptis chinensis, Poria cocos and Atractylodes macrocephala, add water and decoct 3 times, each time for 1.5h, to obtain a decoction ;

[0060] S2) Filtrate the decoction in step S1, concentrate the filtrate into a clear paste with a relative density of 1.10-1.20 (60°C thermal measurement), and dry to obtain the extract powder, that is, the flavored Xiaobupleurum composition.

Embodiment 2

[0061] Embodiment 2, a kind of Xiao Bupleurum composition with flavoring

[0062] The flavored Xiao Bupleurum composition is made from the following raw materials by weight:

[0063] Bei Bupleurum 250g; Scutellaria baicalensis 167g; Codonopsis 167g; Pinellia 167g; Ginger 167g;

[0064] The preparation method of the flavored Xiao Bupleurum composition comprises the following steps:

[0065] S1) Take the formula amount of Bupleurum bupleurum, Scutellaria baicalensis, Codonopsis pilosula, Pinellia chinensis, ginger, jujube, licorice, dried ginger, Coptis chinensis, Poria cocos and Atractylodes macrocephala, add water and decoct 3 times, each time for 1.5h, to obtain a decoction ;

[0066]S2) filtering the decoction in step S1, concentrating the filtrate into a clear paste with a relative density of 1.10-1.20 (60°C thermal measurement), drying to obtain extract powder;

[0067] S3) Mix and stir the extract powder, the purification reagent and water, place in a water bath at 7...

Embodiment 3

[0070] Embodiment 3, a kind of Xiao Bupleurum composition with flavoring

[0071] The flavored Xiao Bupleurum composition is made from the following raw materials by weight:

[0072] Bei Bupleurum 225g; Scutellaria baicalensis 180g; Codonopsis 180g; Pinellia 180g; Ginger 167g;

[0073] The preparation method of the flavored Xiao Bupleurum composition comprises the following steps:

[0074] S1) Take the formula amount of Bupleurum bupleurum, Scutellaria baicalensis, Codonopsis pilosula, Pinellia chinensis, ginger, jujube, licorice, dried ginger, Coptis chinensis, Poria cocos and Atractylodes macrocephala, add water and decoct 3 times, each time for 1.5h, to obtain a decoction ;

[0075] S2) filtering the decoction in step S1, concentrating the filtrate into a clear paste with a relative density of 1.10-1.20 (60°C thermal measurement), drying to obtain extract powder;

[0076] S3) Mix and stir the extract powder, purification reagent and water, place in a water bath at 70° ...

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Abstract

The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to flavored Xiaobupleurum granules and a preparation method thereof. The flavored Xiaobupleurum composition of the present invention is prepared from the following raw materials by weight: 225-275g of Bupleurum chinensis; 150-200g of Scutellaria baicalensis; 150-200g of Codonopsis pilosula; 150-200g of Pinellia chinensis; 150-200g of ginger; 475~525g; Zhigancao 75~125g; Dried Ginger 75~125g; Coptis 25~75g; Poria 225~275g; Atractylodes macrocephala 150~200g. The flavored Xiaobupleurum granule of the present invention increases the content of active ingredients liquiritin, baicalin, berberine hydrochloride, wogonin, baicalein and ammonium glycyrrhizinate in the raw medicine, and plays an excellent role in relieving Shaoyang and harmonizing the stomach and reducing adverse reactions. , the effect of invigorating the spleen and eliminating swelling.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to flavored Xiaobupleurum granules and a preparation method thereof. Background technique [0002] Xiaochaihu Decoction is an effective traditional Chinese medicine prescription summed up by Chinese medical sages in the Eastern Han Dynasty based on the symptoms of patients with spleen and stomach diseases at that time. It has been used for more than two thousand years, and later generations call it a classic prescription. The composition of the classic prescription is: Bupleurum, Scutellaria, Ginseng, Banxiaqing, Licorice Sunburn, Ginger Cut and Jujube Break. However, with the historical changes such as the long span of time, huge differences in geographical environments, and differences in human physique, classic prescriptions are far from meeting the needs of modern diseases. [0003] At the same time, the current traditional Chinese medicine has...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9068A61K47/18A61K47/36A61K9/16A61P1/14A61P1/00
CPCA61K9/1617A61K9/1652A61K36/076A61K36/233A61K36/284A61K36/344A61K36/484A61K36/539A61K36/718A61K36/725A61K36/8888A61K36/9068A61K47/18A61K47/36A61K2236/331A61K2236/39A61K2236/51A61P1/00A61P1/14A61K2300/00
Inventor 周爱军刘焱文吴谋
Owner 东莞市中医院
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