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Iodine-starch aerogel and preparation method and application thereof

An aerogel and starch technology, applied in the field of aerogel, can solve problems such as poor stability of available iodine, and achieve the effects of excellent antibacterial properties, good biocompatibility and simple preparation method

Active Publication Date: 2020-04-10
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Purpose of the invention: for the poor stability of available iodine in existing iodine-containing bactericides, the present invention utilizes soluble starch as a carrier to prepare a Stable iodine-starch aerogels and their use in antibacterial applications disclosed

Method used

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  • Iodine-starch aerogel and preparation method and application thereof
  • Iodine-starch aerogel and preparation method and application thereof
  • Iodine-starch aerogel and preparation method and application thereof

Examples

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Effect test

Embodiment 1

[0037] The preparation of iodine-starch airgel comprises the following steps:

[0038] (1) Mix potassium iodide and iodine element according to the mass ratio of 2:1, add appropriate amount of water to make the iodine concentration 15mg mL –1 , sonicate until all solids are completely dissolved;

[0039] (2) Weigh soluble starch (the molecular weight distribution range is 800–6000), add appropriate amount of water, heat and stir until all solids are completely dissolved, so that the concentration of soluble starch is 30mg mL –1 , naturally cooled to room temperature;

[0040] (3) According to the mass ratio of iodine to starch 1:50, add the solution in (1) to the soluble starch solution obtained in step (2), mix well and take an appropriate amount of liquid in a 96-well plate (200 μL / well), 24-well plate (2mL / well) and 6-well plates (5mL / well), freeze overnight at -80°C, freeze-dry and remove from the above mold to obtain three different sizes of iodine-starch aerogels.

[...

Embodiment 2

[0043] The water dissolution of iodine-starch airgel comprises the following steps:

[0044] Take an appropriate amount of water in any container, add an appropriate volume of iodine-starch airgel to obtain an iodine-starch solution. Available iodine concentration is 10μg mL –1 The UV-Vis absorption spectrum of the iodine-starch solution is shown in Figure 4 .

Embodiment 3

[0046]After storing for a certain period of time, the mensuration of available iodine content in iodine-starch solution, Lugol's iodine solution and povidone-iodine solution comprises the following steps:

[0047] (1) Prepare 3 mL of available iodine to be 50 μg mL –1 Lugol's iodine solution, povidone iodine solution, and iodine-starch solution are stored in centrifuge tubes respectively (all solutions are protected from light);

[0048] (2) Measure the ultraviolet-visible absorption spectra of the above three groups of solutions every day.

[0049] (3) Utilize the ultraviolet-visible absorption spectrum to measure the absorbance at 350nm place to calculate the relative content of remaining available iodine in the solution: available iodine relative content=Abs 350 (day n) / Abs 350 (Day 0)*100%.

[0050] The change curves of the effective iodine concentration of the three iodine-containing fungicides during a one-week storage period are as follows: Figure 5 shown.

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Abstract

The invention discloses an iodine-starch aerogel and its preparation method and application in the antibacterial field. The preparation method comprises the following steps: taking soluble starch andiodine as raw materials, mixing the soluble starch and iodine in a solution, and making the solution into aerogel to obtain the iodine-starch aerogel. Compared with the prior art, the invention innovatively uses soluble starch as an iodine carrier to prepare the iodine-starch aerogel. Compared with stability of the Lugol's iodine solution (a potassium iodide solution of iodine) and commercial povidone iodine, the stability of iodine loaded in the aerogel is significantly improved. In addition, the iodine-starch aerogel has excellent solubility and antibacterial properties, can be used as an antibacterial agent and iodine-containing food, and has a remarkable effect. Besides, the preparation method of the invention is simple, the raw materials are safe and easily available, and the cost islow.

Description

technical field [0001] The technical field of airgel of the present invention particularly relates to an iodine-starch airgel and its preparation method and application in antibacterial. Background technique [0002] Iodine is an essential trace element for the human body. Elemental iodine is a highly efficient, broad-spectrum and less irritating bactericide, which has been used to treat microbial infections for more than 160 years. More importantly, no microbial resistance to iodine has been reported so far. In the current severe situation of antibiotic resistance, the importance of iodine in sterilization has been highlighted. A variety of iodine-containing fungicides are widely used in clinical and daily life for skin surface disinfection, mainly including Lugol's iodine solution, iodine tincture and povidone-iodine. Lugol's iodine solution is potassium iodide solution of iodine; tincture of iodine is ethanol solution of iodine, because it contains ethanol, it will cau...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K47/36A61K33/18A61P31/04A23L3/3463A23L3/358
CPCA61K9/0087A61K47/36A61K33/18A61P31/04A23L3/3463A23L3/358Y02A50/30
Inventor 吴富根孙炜郭育新李俊英
Owner SOUTHEAST UNIV
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