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Preparation method of chitosan-based composite antibacterial dressing

A compound antibacterial and chitosan technology, applied in medical science, absorbent pads, bandages, etc., can solve the problems of wound deterioration, inability to promote the proliferation and growth of epidermal fibroblasts, etc., to promote value-added, excellent osmotic fluid absorption, biological Excellent compatibility

Inactive Publication Date: 2020-04-03
安徽省小山卫生材料有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, the medical dressings prepared in the prior art cannot effectively prevent the deterioration of the patient's wound, and cannot effectively promote the proliferation and growth of epidermal fibroblasts.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] A preparation method of chitosan-based composite antibacterial dressing, comprising the following steps:

[0022] (1) Add konjac glucomannan and hemp fiber powder with a thickness of 10-15 μm and a length of 0.03-0.06 mm into deionized water at a mass ratio of 18:1, and continue stirring until a uniform dispersion is obtained, Add 65% oxidant sodium periodate of konjac glucomannan quality to it, after the oxidation reaction, add deionized water volume 10% ethylene glycol to remove unreacted sodium periodate, and concentrate the reaction product by rotary evaporation to one-third of the volume, centrifuged to collect the centrifuged supernatant after dialysis, concentrated by rotary evaporation and dried at a constant temperature, and then ground into a powder with an average particle size of 600 mesh to obtain powder A.

[0023] (2) In parts by weight, mix 15 parts of carboxymethyl chitosan, 1 part of seaweed extract, and 2 parts of peppermint extract into 280 parts of ...

Embodiment 2

[0025] A preparation method of chitosan-based composite antibacterial dressing, comprising the following steps:

[0026] (1) Add konjac glucomannan and hemp fiber powder with a thickness of 10-15 μm and a length of 0.03-0.06 mm into deionized water at a mass ratio of 20:1, and continue stirring until a uniform dispersion is obtained, Add 68% oxidant sodium periodate of konjac glucomannan quality to it, after the oxidation reaction, add deionized water volume 13% ethylene glycol to remove unreacted sodium periodate, and the reaction product is concentrated by rotary evaporation to one-third of the volume, centrifuged to collect the centrifuged supernatant after dialysis, concentrated by rotary evaporation and dried at a constant temperature, and then ground into a powder with an average particle size of 700 mesh to obtain powder A.

[0027] (2) In parts by weight, mix 20 parts of carboxymethyl chitosan, 2 parts of seaweed extract, and 3 parts of peppermint extract into 300 part...

Embodiment 3

[0029] A preparation method of chitosan-based composite antibacterial dressing, comprising the following steps:

[0030] (1) Add konjac glucomannan and hemp fiber powder with a thickness of 10-15 μm and a length of 0.03-0.06 mm into deionized water at a mass ratio of 22:1, and continue stirring until a uniform dispersion is obtained. Add 70% oxidant sodium periodate of konjac glucomannan quality to it, after the oxidation reaction, add ethylene glycol with 15% volume of deionized water to remove sodium periodate that has not participated in the reaction, and concentrate the reaction product by rotary evaporation to one-third of the volume, centrifuged to collect the centrifuged supernatant after dialysis, concentrated by rotary evaporation and dried at a constant temperature, and then ground into a powder with an average particle size of 800 mesh to obtain powder A.

[0031] (2) In parts by weight, after mixing 25 parts of carboxymethyl chitosan, 3 parts of seaweed extract, an...

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Abstract

The invention discloses a preparation method of a chitosan-based composite antibacterial dressing. The method comprises the following operation steps: (1) carrying out oxidation reaction on konjac glucomannan and hemp fiber powder by adopting an oxidizing agent sodium periodate to obtain a powder A; and (2) mixing and adding carboxymethyl chitosan, seaweed extract and mint extract into water, continuously performing mixing and stirring until a uniformly mixed dispersion system appears, adding a plasticizer into the system, adding a powder A solution into the system, injecting the obtained mixture into a polytetrafluoroethylene culture dish, sealing the dish with a preservative film, performing standing for cross-linking reaction, putting the dish into a refrigerator for pre-freezing, transferring the dish to an environment of -38 DEG C to -35 DEG C for treatment, and finally performing freeze-drying to obtain the chitosan-based composite antibacterial dressing. The chitosan-based composite antibacterial dressing prepared by the method has an excellent permeation absorption effect, an excellent antibacterial effect and excellent biocompatibility, and can effectively promote proliferation of epidermal fibroblasts and accelerate wound healing.

Description

technical field [0001] The invention belongs to the technical field of preparation of medical antibacterial dressings, and in particular relates to a preparation method of chitosan-based composite antibacterial dressings. Background technique [0002] In the past 20 years, chitosan and some natural polymer materials have been widely used in the fields of biomaterials and medical dressings, such as wound sutures, drug sustained release carriers, tissue engineering scaffolds, etc. In the research of many natural polymer materials, chitosan has been in the upsurge of research in various fields for a long time due to its many advantages and unique properties. Chitosan is a product formed by deacetylation of chitin, that is, deacetylated chitin, also known as chitin and chitin, is the only cationic and biodegradable natural high molecular material. Chitosan is widely found in the shells of shrimps, crabs and arthropods, and in the cell walls of some lower plants. It is a very r...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/28A61L15/42A61L15/44A61L15/46
CPCA61L15/28A61L15/425A61L15/44A61L15/46A61L2300/30A61L2300/404A61L2300/412C08L5/08C08L5/02C08L5/04
Inventor 周小山
Owner 安徽省小山卫生材料有限公司
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