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A rare earth up-conversion diagnosis and treatment integrated nanocomposite material, preparation method and application thereof

A nanocomposite material and rare earth up-conversion technology, which can be used in photodynamic therapy, preparations for in vivo experiments, wave energy or particle radiation treatment materials, etc., and can solve problems such as inability to meet PDT

Active Publication Date: 2021-05-11
SHANGHAI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, in the prior art, due to the limitations of the preparation process and the performance of material components, few photosensitizers can be directly excited by NIR light to generate enough reactive oxygen species ROS, so it cannot meet the requirements of PDT with a unique structure and is not easy to degrade photosensitizers to generate enough cytotoxic reactive oxygen species ROS to achieve the desired therapeutic effect
At the same time, there is currently no nanocomposite material that meets the needs of PDT and has the function of fluorescence imaging for the diagnosis of cancer diseases, combining the treatment together, so as to have the integrated function of diagnosis and treatment.

Method used

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  • A rare earth up-conversion diagnosis and treatment integrated nanocomposite material, preparation method and application thereof
  • A rare earth up-conversion diagnosis and treatment integrated nanocomposite material, preparation method and application thereof
  • A rare earth up-conversion diagnosis and treatment integrated nanocomposite material, preparation method and application thereof

Examples

Experimental program
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Embodiment 1

[0033]The rare earth-converted diagnosis and treatment of the present invention is integrated with a nanocomposite of the oil-soluble nanoparticles as a core, and the oxide copper (Cu)2O) The upper conversion of the surface epitaxial growth of the nanoparticles surface epitaxial, the formed interface is a nuclear growth of the nanocomposite; of which of which of the copper oxide (Cu)2O) Direct excitation of near-infrared light (NIR) can produce sufficient active oxygen (ROS), thereby playing therapeutic effect on killing cancer cells to achieve the demand of photodynamic therapy (PDT); Conversion of the luminous nanoparticles cooperate to achieve diagnosis and treatment.

[0034]The oil-soluble rare earth conversion luminous nanoparticles include: NAYF4: Yb, er, NAYF4: YB, TM, NAYF4: YB, ER, TM, NAYF4: Yb, er @ nagdf4NAYF4: YB, TM @ nagdf4NAYF4: YB, ER, TM @ NAGDF4NAYF4: Yb, er @ NAYF4: ND, YB, NAYF4: YB, TM @ NAYF4: One or more of ND, YB. In other embodiments, there is also a structur...

Embodiment 2

[0042]The composite material provided in this example and the preparation method thereof, specifically a rare earth-doped conversion of nanoparticles epitaxial growth, which is substantially the same as that of Example 1, which includes the following steps. :

[0043](1) Preliminary particle size of oil-soluble rare earth 铥 doped by oil-soluble rare earth 铥 doped by a particle diameter;

[0044](2) Preparation Cu (NO3)2Solution, weigh 0.2 ~ 0.3g Cu (NO3)2Soluble in 35 ~ 50ml deionized water, then dissolve the good Cu (NO3)2The solution was added dropwise to the obtained oil-soluble rare earth conversion luminous nanoparticles, and stirred vigorously for 15 to 60 minutes at room temperature to obtain the first dispersion;

[0045](3) Preparation of 0.5 ~ 2 mol / L hydride solution, 8 to 10 ml of hydrated hydrazine solution was rapidly added to the first dispersion to carry out mixing, observed that the solution color became yellow from blue, vigorously stirred for 1 to 2h, Further, the obtain...

Embodiment 3

[0048]The composite material provided herein and the preparation method thereof, specifically a rare earth ruthenium / co-doping-doped nanoparticle epitaxial growth of a copper nanocomposite, which is substantially the same as those of Examples 1 and 2, and the difference is that it is It includes the following steps:

[0049](1) The preparatory rare earth cerium / co-doping of the particle size of 25 to 30 nm is converted to convert the luminous nanoparticles;

[0050](2) Preparation Cu (NO3)2Solution, weigh 0.2 ~ 0.3g Cu (NO3)2Soluble in 35 ~ 50ml deionized water, then dissolve the good Cu (NO3)2The solution was added dropwise to the obtained oil-soluble rare earth conversion luminous nanoparticles, and stirred vigorously for 15 to 60 minutes at room temperature to obtain the first dispersion;

[0051](3) Preparation of 0.5 ~ 2 mol / L hydride solution, 8 to 10 ml of hydrated hydrazine solution was rapidly added to the first dispersion to carry out mixing, observed that the solution color ...

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Abstract

The invention discloses a rare earth up-conversion diagnosis and treatment integrated nanocomposite material, which uses oil-soluble up-conversion luminescent nanoparticles (UCNPs) as the core, and makes cuprous oxide (Cu 2 O) the epitaxial growth on the surface of the up-conversion nanoparticle is a shell, and the cuprous oxide-modified rare earth up-conversion nanocomposite material of the interface nucleation growth formed; wherein Cu 2 O can perform fluorescence resonance energy transfer with the up-conversion emission of UCNPs excited by near-infrared light, and then generate enough active oxygen to meet the needs of photodynamic therapy; at the same time, it can cooperate with the oil-soluble up-conversion luminescent nanoparticles to realize diagnosis and treatment. integration. The invention also provides a preparation method of the material, which comprises the steps of using the oil-soluble up-conversion luminescent nano-particles as nuclei, and nucleating and growing cuprous oxide on the surface of the up-conversion nano-particles. The nanocomposite material of the invention has uniform size, good stability and good biocompatibility, can be used for photodynamic therapy guided by imaging diagnosis, and meets the requirement of clinical diagnosis and treatment integration.

Description

Technical field[0001]The present invention relates to the field of nano-biomaterials, and more particularly to a rare earth conversion diagnosis and treatment integrated nanocomposite, preparation method and its application thereof.Background technique[0002]Cancer has become one of the major diseases that endanger human health. The traditional anti-cancer methods have some limitations, such as chemotherapy, resistance, radiotherapy has severe side effects, and surgery have high recurrence rate.[0003]Photodynamic Therapy (PDT) is an emerging treatment means in recent years. It has the advantages of good controllability and small side effects. The principle is that the photosensitizer is excited under the light source, and the surrounding oxygen molecules produces an active oxygen, and the important structure and function of the cells will ultimately achieve the purpose of destroying the disease.[0004]Due to the accurate and predictable response to the phototherapy of specific lesions...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K49/00A61K41/00A61P35/00
CPCA61K41/0057A61K49/0019A61K49/0093A61P35/00
Inventor 孙丽宁裴世豪施利毅赵慧君王卓
Owner SHANGHAI UNIV
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