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Application of cobratide preparation in preparation of medicine for treating haemorrhoids

A technology of Kebo peptide and preparation, applied in the field of drug application, can solve the problems of Kebo peptide hemorrhoids that have not been reported.

Active Publication Date: 2020-03-31
云南南诏药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] At present, there is no report on the research of cobotide in the treatment of hemorrhoids

Method used

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  • Application of cobratide preparation in preparation of medicine for treating haemorrhoids
  • Application of cobratide preparation in preparation of medicine for treating haemorrhoids

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0028] Experimental example 1 Acetic acid-induced pain writhing experiment

[0029] 1. Experimental objects: 100 SPF grade Kunming mice, half male and half male, weighing 18-22g.

[0030]2. Experimental method: 100 mice were randomly divided into experimental group 1-5, comparison group 1-3, positive control group (Xiaozhiling injection), and blank control group, with 10 mice in each group, half male and half male; experiment The mice in group 1 were injected intramuscularly with Cobotide injection, 0.57ml once a day, twice a day, and the time between the two injections was longer than 6 hours; the mice in experimental group 2 were given Kobotide oral tablets, once a day, 0.018g each time; Experimental group 3 was fed with Cobotide enteric-coated tablets, once a day, 0.018g each time; Experimental group 4 mice were rectally administered Kobotide suppositories, 2 times a day, 0.28g each time ; In the experimental group 5, the mice were administered to the oral mucosa, and the ...

experiment example 2

[0034] Experimental example 2 hemostasis experiment

[0035] 1. The experimental object is the same as the experimental example 1

[0036] 2. Experimental method: the administration method is the same as that of Experimental Example 1. One hour after the last administration, the coagulation time and bleeding time of each mouse were measured by capillary method and tail-cutting method. Insert a capillary glass tube with an inner diameter of 1 mm into the venous plexus of the mouse medial canthus to collect blood, so that the blood column in the capillary glass tube reaches 5 cm, break a small section of glass tube every 30 s, and observe whether there is blood coagulation thread, from the blood collection to the appearance The time of hemagglutination is the coagulation time. Put the mouse in the holder, cut off the tail with sharp scissors from 1.5cm from the tip of the tail, count the time when the blood overflows by itself, absorb the blood with filter paper every 30s, and...

experiment example 3

[0040] Experimental example 3 Influence test of mouse peritonitis exudation caused by acetic acid

[0041] 1. The experimental object is the same as the experimental example 1

[0042] 2. Experimental method: the administration method is the same as that of Experimental Example 1. 1 hour after the last administration, each mouse was injected with 0.5% Evans blue 0.1ml / mouse into the tail vein, and 0.6% acetic acid solution 0.1ml / 10g was injected intraperitoneally 10 minutes later, and then killed by decapitation 20 minutes after the injection, the abdominal cavity was washed with normal saline, and all the mice were collected and washed. After centrifugation, take the supernatant and measure its OD value at a wavelength of 578nm in a semi-automatic biochemical analyzer. The OD value represents the concentration of Evans blue in the washing liquid, which indirectly reflects the degree of peritonitis exudation; the results are shown in Table 3 Show:

[0043] table 3

[0044] ...

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Abstract

The invention relates to an application of a cobratide preparation in preparation of a medicine for treating haemorrhoids. The cobratide which is a main component of the cobratide preparation is neurotoxin protein separated and purified from cobra venom, and the content of the neurotoxin protein is not less than 35.0 percent according to a dry product; the preparation is an injection, an oral preparation, an enteric preparation, a rectal administration preparation, an oral absorption preparation and the like. The cobratide preparation has a good effect on main symptoms such as hematochezia, prolapse, anal pendant expansion, pain, anal foreign body sensation and the like represented by haemorrhoids. In addition, animal experiments prove that the preparation provided by the invention has thecurative effect of treating hemorrhoid-related diseases, and provides another choice for patients.

Description

technical field [0001] The invention relates to the technical field of drug application, in particular to the application of cobotide preparations in the preparation of drugs for treating hemorrhoids. Background technique [0002] Hemorrhoids, also known as hemorrhoids, are one of the most common anorectal diseases. Clinically, they are mainly divided into three types: internal hemorrhoids, external hemorrhoids, and mixed hemorrhoids. The population prevalence rate is 39%, of which 44.7% are accompanied by clinical symptoms. At present, the cause of hemorrhoids has not been fully elucidated, and it is related to many factors. The theory of varicose veins is widely recognized at present. The theory of varicose veins believes that hemorrhoids are venous clusters formed by the congestion, expansion and buckling of the venous plexus under the mucous membrane of the lower rectum and the skin of the anal canal; Constipation, pregnancy, ascites, and huge pelvic tumors can all hin...

Claims

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Application Information

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IPC IPC(8): A61K38/17A61P9/14
CPCA61K38/1703A61P9/14Y02A50/30
Inventor 窦啟玲窦雅琪李泽京苏家彪
Owner 云南南诏药业有限公司
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